Psychopharmacology (2018) 235:673–680 https://doi.org/10.1007/s00213-017-4783-6 ORIGINAL INVESTIGATION Δ -Tetrahydrocannabinol-like discriminative stimulus effects of five novel synthetic cannabinoids in rats 1 1 Michael B. Gatch & Michael J. Forster Received: 1 June 2017 /Accepted: 5 November 2017 /Published online: 14 November 2017 Springer-Verlag GmbH Germany, part of Springer Nature 2017 Abstract have abuse liability similar to that of the controlled cannabi- Rationale and objectives Novel synthetic cannabinoid com- noid compounds. pounds continue to appear in the market advertised as legal . . alternatives to marijuana and the older synthetic cannabinoid Keywords Cannabinoids Drug discrimination Locomotor . . . compounds which are now controlled substances. Most of activity Abuse liability Mouse Rat these newer compounds have been found to act at CB1 receptors, so the purpose of this study was to study the abuse liability of these compounds. Introduction Methods Five of these compounds (BB-22, FUB-PB-22, 5F-AMB, NM2201, and MAB-CHMINACA) were tested Synthetic compounds that mimic the effects of controlled sub- for their ability to produce discriminative stimulus effects stances such as psychostimulants, cannabis, and hallucino- 9 9 similar to Δ -tetrahydrocannabinol (Δ -THC) in rats. The gens have continued their increase in popularity among recre- ability of the CB1 receptor inverse
Psychopharmacology – Springer Journals
Published: Nov 14, 2017
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