8th international congress “sepsis and multiorgan dysfunction”

8th international congress “sepsis and multiorgan dysfunction” Infection (2017) 45 (Suppl 1):S1–S66 DOI 10.1007/s15010-017-1046-8 Abstracts 8th International Congress ‘‘Sepsis and Multiorgan Dysfunction’’ Weimar Sepsis Update 2017– Facing the Challenges September 6–8, 2017 Weimar Organizer H. Gerlach T. Welte F. M. Brunkhorst Guest Editors F. M. Brunkhorst T. Welte H. Gerlach German Sepsis Society (DSG) http://www.sepsis-gesellschaft.de 123 S2 Abstracts Dear colleagues, During the last two decades, multiple treatment modalities have been tested in the attempt to improve clinical outcomes from sepsis. During this period we have consistently observed initially promising results that have gradually faded in subsequent large clinical trials. Researchers blame this irreproducibility on slow patient accrual (selection bias), the Hawthorn effect (knowing you are being watched changes your practice), beta-type errors (false positive), publi- cation bias and other factors. In a recent publication (Mebazaa et al. Journal of Intensive Care (2016) 4:24) the authors stated, that the major reasons for lack of survival in recent sepsis trials are over-estimated treatment effects, suboptimal pre-clinical models, incorrect treatment targets, and heterogeneity of definitions and patients. Priorities for future sepsis clinical trials are among others, identi- fication of responders to treatment, networks of sepsis investigators experienced in clinical trial conduct, application of the recent S-3 definitions for sepsis http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Infection Springer Journals

8th international congress “sepsis and multiorgan dysfunction”

Infection , Volume 45 (1) – Aug 10, 2017

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag GmbH Germany
Subject
Medicine & Public Health; Infectious Diseases; General Practice / Family Medicine; Internal Medicine
ISSN
0300-8126
eISSN
1439-0973
D.O.I.
10.1007/s15010-017-1046-8
Publisher site
See Article on Publisher Site

Abstract

Infection (2017) 45 (Suppl 1):S1–S66 DOI 10.1007/s15010-017-1046-8 Abstracts 8th International Congress ‘‘Sepsis and Multiorgan Dysfunction’’ Weimar Sepsis Update 2017– Facing the Challenges September 6–8, 2017 Weimar Organizer H. Gerlach T. Welte F. M. Brunkhorst Guest Editors F. M. Brunkhorst T. Welte H. Gerlach German Sepsis Society (DSG) http://www.sepsis-gesellschaft.de 123 S2 Abstracts Dear colleagues, During the last two decades, multiple treatment modalities have been tested in the attempt to improve clinical outcomes from sepsis. During this period we have consistently observed initially promising results that have gradually faded in subsequent large clinical trials. Researchers blame this irreproducibility on slow patient accrual (selection bias), the Hawthorn effect (knowing you are being watched changes your practice), beta-type errors (false positive), publi- cation bias and other factors. In a recent publication (Mebazaa et al. Journal of Intensive Care (2016) 4:24) the authors stated, that the major reasons for lack of survival in recent sepsis trials are over-estimated treatment effects, suboptimal pre-clinical models, incorrect treatment targets, and heterogeneity of definitions and patients. Priorities for future sepsis clinical trials are among others, identi- fication of responders to treatment, networks of sepsis investigators experienced in clinical trial conduct, application of the recent S-3 definitions for sepsis

Journal

InfectionSpringer Journals

Published: Aug 10, 2017

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