Infection (2017) 45 (Suppl 1):S1–S66 DOI 10.1007/s15010-017-1046-8 Abstracts 8th International Congress ‘‘Sepsis and Multiorgan Dysfunction’’ Weimar Sepsis Update 2017– Facing the Challenges September 6–8, 2017 Weimar Organizer H. Gerlach T. Welte F. M. Brunkhorst Guest Editors F. M. Brunkhorst T. Welte H. Gerlach German Sepsis Society (DSG) http://www.sepsis-gesellschaft.de 123 S2 Abstracts Dear colleagues, During the last two decades, multiple treatment modalities have been tested in the attempt to improve clinical outcomes from sepsis. During this period we have consistently observed initially promising results that have gradually faded in subsequent large clinical trials. Researchers blame this irreproducibility on slow patient accrual (selection bias), the Hawthorn effect (knowing you are being watched changes your practice), beta-type errors (false positive), publi- cation bias and other factors. In a recent publication (Mebazaa et al. Journal of Intensive Care (2016) 4:24) the authors stated, that the major reasons for lack of survival in recent sepsis trials are over-estimated treatment effects, suboptimal pre-clinical models, incorrect treatment targets, and heterogeneity of deﬁnitions and patients. Priorities for future sepsis clinical trials are among others, identi- ﬁcation of responders to treatment, networks of sepsis investigators experienced in clinical trial conduct, application of the recent S-3 deﬁnitions for sepsis
Infection – Springer Journals
Published: Aug 10, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera