3-Naphthylindoles as new promising candidate antioxidant, antibacterial, and antibiofilm agents

3-Naphthylindoles as new promising candidate antioxidant, antibacterial, and antibiofilm agents Keywords Indole derivatives  Antioxidant  Antibacterial  Antibiofilm Introduction Indoles represent some of the most important pharmacophore and privileged structures in medicinal chemistry [1]. They exert a range of biological activities, such as anticancer [2], antibacterial [3], antioxidant [4], antiinflammatory [5], antituberculosis [6], antidiabetic [7], antidepressant [8], nonpeptidyl GnRH receptor antagonist [9], PPAR-c partial agonist [10], h5-HT2A receptor antagonist [11], antiapoptotic Mc1-1 protein inhibition [12], endothelin antagonist [13], and AKT- mTOR signaling pathway kinase inhibitor actions [14]. Some of these compounds are currently considered to be potential drugs or are lead compounds for development of new medicines. They are also widely used as building blocks for construction of functionalized indole derivatives [15, 16]. Molecules bearing a 2-naphthol moiety are valuable compounds possessing a range of important biological and pharmacological properties [17]. Owing to the wide spectrum of indole derivatives and their biological properties, several studies have examined the antioxidant, antibacterial, and antibiofilm activities of natural or synthetic indole derivatives [18, 19]. Antioxidants are molecules capable of consuming free radicals formed by oxidative processes in food, drugs, and living systems [20]. Reactive oxygen species (ROS) are constantly formed in the human body as a result of normal organ function http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

3-Naphthylindoles as new promising candidate antioxidant, antibacterial, and antibiofilm agents

Loading next page...
 
/lp/springer_journal/3-naphthylindoles-as-new-promising-candidate-antioxidant-antibacterial-pYJz0yygsN
Publisher
Springer Netherlands
Copyright
Copyright © 2016 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-016-2768-4
Publisher site
See Article on Publisher Site

Abstract

Keywords Indole derivatives  Antioxidant  Antibacterial  Antibiofilm Introduction Indoles represent some of the most important pharmacophore and privileged structures in medicinal chemistry [1]. They exert a range of biological activities, such as anticancer [2], antibacterial [3], antioxidant [4], antiinflammatory [5], antituberculosis [6], antidiabetic [7], antidepressant [8], nonpeptidyl GnRH receptor antagonist [9], PPAR-c partial agonist [10], h5-HT2A receptor antagonist [11], antiapoptotic Mc1-1 protein inhibition [12], endothelin antagonist [13], and AKT- mTOR signaling pathway kinase inhibitor actions [14]. Some of these compounds are currently considered to be potential drugs or are lead compounds for development of new medicines. They are also widely used as building blocks for construction of functionalized indole derivatives [15, 16]. Molecules bearing a 2-naphthol moiety are valuable compounds possessing a range of important biological and pharmacological properties [17]. Owing to the wide spectrum of indole derivatives and their biological properties, several studies have examined the antioxidant, antibacterial, and antibiofilm activities of natural or synthetic indole derivatives [18, 19]. Antioxidants are molecules capable of consuming free radicals formed by oxidative processes in food, drugs, and living systems [20]. Reactive oxygen species (ROS) are constantly formed in the human body as a result of normal organ function

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Oct 18, 2016

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off