3-Naphthylindoles as new promising candidate antioxidant, antibacterial, and antibiofilm agents

3-Naphthylindoles as new promising candidate antioxidant, antibacterial, and antibiofilm agents Keywords Indole derivatives  Antioxidant  Antibacterial  Antibiofilm Introduction Indoles represent some of the most important pharmacophore and privileged structures in medicinal chemistry [1]. They exert a range of biological activities, such as anticancer [2], antibacterial [3], antioxidant [4], antiinflammatory [5], antituberculosis [6], antidiabetic [7], antidepressant [8], nonpeptidyl GnRH receptor antagonist [9], PPAR-c partial agonist [10], h5-HT2A receptor antagonist [11], antiapoptotic Mc1-1 protein inhibition [12], endothelin antagonist [13], and AKT- mTOR signaling pathway kinase inhibitor actions [14]. Some of these compounds are currently considered to be potential drugs or are lead compounds for development of new medicines. They are also widely used as building blocks for construction of functionalized indole derivatives [15, 16]. Molecules bearing a 2-naphthol moiety are valuable compounds possessing a range of important biological and pharmacological properties [17]. Owing to the wide spectrum of indole derivatives and their biological properties, several studies have examined the antioxidant, antibacterial, and antibiofilm activities of natural or synthetic indole derivatives [18, 19]. Antioxidants are molecules capable of consuming free radicals formed by oxidative processes in food, drugs, and living systems [20]. Reactive oxygen species (ROS) are constantly formed in the human body as a result of normal organ function http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

3-Naphthylindoles as new promising candidate antioxidant, antibacterial, and antibiofilm agents

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Springer Netherlands
Copyright © 2016 by Springer Science+Business Media Dordrecht
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
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