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Treatment of Alzheimer’s Disease

Treatment of Alzheimer’s Disease CHAPTER 7 LON S. SCHNEIDER DEPAlnMENT OF PSYCHIATRY AND THE BEHAVIORAL SClENCES UNIVERSITY OF SoUTHER.l\I CALIFORNIA INTRODUCTION Therapeutic approaches to the cognitive impairment of dementia are making their way into clinical practice, albeit more slowly than previ­ ously anticipated. Clinical pharmacological approaches toward improve­ ment of cognitive symptoms will be discussed, with an emphasis on cholinergic approaches since they atc most developed, and additional cholinesterase inhibitors may soon be available for prescribing. The cholinergic deficit-although by no means the only deficit in an illness character ized by progressive nerve cell damage and death--occurs ea rl y in th e disease and perhaps to a much greater and denser degree than deficits to o th er neuronal systems. Table 7.2 outlines pharmacologic ther­ apies considered in this chapter. Pharmacologic agcnts that increase cholinergic function in the central nervous system (CNS) have shown effi­ cacy in improving cognitive symptoms, and remain an inten sive ly researched area. As more knowledge is gained about dosing, side effects, and mechanisms of act ion, these drugs can be prescribed with greater deliberation. Drugs that improve cognition also may h ave effects on behavioral symptoms, severe dementia, and non-Alzheimer's dementia, although the evidence for thi http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Gerontology & Geriatrics Springer Publishing

Treatment of Alzheimer’s Disease

Annual Review of Gerontology & Geriatrics , Volume 19 (1): 16 – Jan 1, 1999

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Publisher
Springer Publishing
ISSN
0198-8794
eISSN
1944-4036
DOI
10.1891/0198-8794.19.1.120
Publisher site
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Abstract

CHAPTER 7 LON S. SCHNEIDER DEPAlnMENT OF PSYCHIATRY AND THE BEHAVIORAL SClENCES UNIVERSITY OF SoUTHER.l\I CALIFORNIA INTRODUCTION Therapeutic approaches to the cognitive impairment of dementia are making their way into clinical practice, albeit more slowly than previ­ ously anticipated. Clinical pharmacological approaches toward improve­ ment of cognitive symptoms will be discussed, with an emphasis on cholinergic approaches since they atc most developed, and additional cholinesterase inhibitors may soon be available for prescribing. The cholinergic deficit-although by no means the only deficit in an illness character ized by progressive nerve cell damage and death--occurs ea rl y in th e disease and perhaps to a much greater and denser degree than deficits to o th er neuronal systems. Table 7.2 outlines pharmacologic ther­ apies considered in this chapter. Pharmacologic agcnts that increase cholinergic function in the central nervous system (CNS) have shown effi­ cacy in improving cognitive symptoms, and remain an inten sive ly researched area. As more knowledge is gained about dosing, side effects, and mechanisms of act ion, these drugs can be prescribed with greater deliberation. Drugs that improve cognition also may h ave effects on behavioral symptoms, severe dementia, and non-Alzheimer's dementia, although the evidence for thi

Journal

Annual Review of Gerontology & GeriatricsSpringer Publishing

Published: Jan 1, 1999

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