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M. Piper, L. Partridge (2007)
Dietary Restriction in Drosophila: Delayed Aging or Experimental Artefact?PLoS Genetics, 3
P. Deininger, M. Batzer (1999)
Alu repeats and human disease.Molecular genetics and metabolism, 67 3
R. Bahar, C. Hartmann, K. Rodriguez, A. Denny, R. Busuttil, M. Dollé, R. Calder, G. Chisholm, B. Pollock, C. Klein, J. Vijg (2006)
Increased cell-to-cell variation in gene expression in ageing mouse heartNature, 441
M. Somel, P. Khaitovich, S. Bahn, S. Pääbo, M. Lachmann (2006)
Gene expression becomes heterogeneous with ageCurrent Biology, 16
R. Skinner, W. Wallace, G. Levitt (2006)
Long-term follow-up of people who have survived cancer during childhood.The Lancet. Oncology, 7 6
T. Sakatani, Atsushi Kaneda, C. Iacobuzio-Donahue, M. Carter, Sten Witzel, H. Okano, M. Ko, R. Ohlsson, D. Longo, A. Feinberg (2005)
Loss of Imprinting of Igf2 Alters Intestinal Maturation and Tumorigenesis in MiceScience, 307
Michelle Hamilton, Zhong Guo, Clinton Fuller, H. Remmen, W. Ward, S. Austad, D. Troyer, I. Thompson, A. Richardson (2001)
A reliable assessment of 8-oxo-2-deoxyguanosine levels in nuclear and mitochondrial DNA using the sodium iodide method to isolate DNA.Nucleic acids research, 29 10
D. Symer, C. Connelly, Suzanne Szak, E. Caputo, G. Cost, G. Parmigiani, J. Boeke (2002)
Human L1 Retrotransposition Is Associated with Genetic Instability In VivoCell, 110
W. Rideout, K. Eggan, R. Jaenisch (2001)
Nuclear Cloning and Epigenetic Reprogramming of the GenomeScience, 293
Orestes Fiandra, PABLO Banizi, H. FIANDRA, DANIEL FIANDRA, BERNARDO ERRAMUN, WALTER ESPASANDIN (1999)
Patients Over 100 Years of Age with Implanted Cardiac PacemakersPacing and Clinical Electrophysiology, 22
M. Vickaryous, B. Hall (2006)
Human cell type diversity, evolution, development, and classification with special reference to cells derived from the neural crestBiological Reviews, 81
Martha Nance, Susan Berry (1992)
Cockayne syndrome: review of 140 cases.American journal of medical genetics, 42 1
C. Darlington (1942)
New Paths in GeneticsNature, 149
Jessie Jeyapalan, Mark Ferreira, J. Sedivy, U. Herbig (2007)
Accumulation of senescent cells in mitotic tissue of aging primatesMechanisms of Ageing and Development, 128
Yun Su, M. Swift (2000)
Mortality Rates among Carriers of Ataxia-Telangiectasia Mutant AllelesAnnals of Internal Medicine, 133
(2005)
Extended life spans “within reach.
J. Yoder, C. Walsh, T. Bestor (1997)
Cytosine methylation and the ecology of intragenomic parasites.Trends in genetics : TIG, 13 8
(2006)
Table 31 . Leading causes of death and numbers of deaths , according to sex , race , and Hispanic origin : United States , 1980 and 2003
Hongying Yang, J. Baur, Allen Chen, Christine Miller, D. Sinclair (2007)
Design and synthesis of compounds that extend yeast replicative lifespanAging Cell, 6
K. Shiota (2004)
DNA methylation profiles of CpG islands for cellular differentiation and development in mammalsCytogenetic and Genome Research, 105
Howard Chang, J. Chi, S. Dudoit, Chanda Bondre, M. Rijn, D. Botstein, P. Brown (2002)
Diversity, topographic differentiation, and positional memory in human fibroblastsProceedings of the National Academy of Sciences of the United States of America, 99
M. Chan (2002)
Antimicrobial effect of resveratrol on dermatophytes and bacterial pathogens of the skin.Biochemical pharmacology, 63 2
N. Fedoroff (1999)
Transposable Elements As a Molecular Evolutionary ForceAnnals of the New York Academy of Sciences, 870
Bard Geesaman, Erica Benson, S. Brewster, L. Kunkel, H. Blanché, G. Thomas, T. Perls, M. Daly, A. Puca (2003)
Haplotype-based identification of a microsomal transfer protein marker associated with the human lifespanProceedings of the National Academy of Sciences of the United States of America, 100
K. Nair, R. Rizza, P. O'brien, K. Dhatariya, K. Short, A. Nehra, J. Vittone, G. Klee, A. Basu, R. Basu, C. Cobelli, G. Toffolo, C. Man, D. Tindall, L. Melton, Glenn Smith, S. Khosla, M. Jensen (2006)
DHEA in elderly women and DHEA or testosterone in elderly men.The New England journal of medicine, 355 16
B. Richardson (2003)
Impact of aging on DNA methylationAgeing Research Reviews, 2
J. Speakman, Darren Talbot, C. Selman, S. Snart, J. McLaren, P. Redman, Ela Krol, D. Jackson, Maria Johnson, M. Brand (2004)
Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longerAging Cell, 3
M. Dollé, J. Vijg (2002)
Genome dynamics in aging mice.Genome research, 12 11
Printed in U.S.A. Copyright © 2005 by The Endocrine Society doi: 10.1210/en.2005-0411 Minireview: Role of the Growth Hormone/Insulin-Like Growth Factor System in Mammalian Aging
K. Robertson (2005)
DNA methylation and human diseaseNature Reviews Genetics, 6
A. Trifunovic, A. Wredenberg, M. Falkenberg, J. Spelbrink, A. Rovio, C. Bruder, M. Bohlooly-y, S. Gidlöf, A. Oldfors, R. Wibom, J. Törnell, H. Jacobs, N. Larsson (2004)
Premature ageing in mice expressing defective mitochondrial DNA polymeraseNature, 429
Charles Epstkin, G. Martin, A. Schultz, Arno Motulskys (1966)
A Review of its Symptomatology, Natural History, Pathologic Features, Genetics And Relationship to the Natural Aging ProcessMedicine, 45
Marie Lagouge, C. Argmann, Z. Gerhart-Hines, H. Meziane, C. Lerin, F. Daussin, N. Messadeq, J. Milne, P. Lambert, P. Elliott, B. Gény, M. Laakso, P. Puigserver, J. Auwerx (2006)
Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1αCell, 127
I. Mahmood, J. Balian (1996)
Interspecies scaling: predicting clearance of drugs in humans. Three different approaches.Xenobiotica; the fate of foreign compounds in biological systems, 26 9
(2005)
We will be able to live to 1,000
R. Jaenisch, A. Bird (2003)
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signalsNature Genetics, 33 Suppl 1
J. Baur, K. Pearson, Nathan Price, H. Jamieson, C. Lerin, Avash Kalra, V. Prabhu, Joanne Allard, G. López-Lluch, Kaitlyn Lewis, P. Pistell, Suresh Poosala, K. Becker, O. Boss, Dana Gwinn, Mingyi Wang, S. Ramaswamy, K. Fishbein, R. Spencer, E. Lakatta, D. Couteur, R. Shaw, P. Navas, P. Puigserver, D. Ingram, R. Cabo, D. Sinclair (2006)
Resveratrol improves health and survival of mice on a high-calorie dietNature, 444
Hyung‐Lyun Kang, S. Benzer, K. Min (2002)
Life extension in Drosophila by feeding a drugProceedings of the National Academy of Sciences of the United States of America, 99
C. West (1979)
A quantitative study of lipofuscin accumulation with age in normals and individuals with Down's syndrome, phenylketonuria, progeria and transneuronal atrophyJournal of Comparative Neurology, 186
D. Harman (1956)
Aging: a theory based on free radical and radiation chemistry.Journal of gerontology, 11 3
B. Yu (2006)
Why calorie restriction would work for human longevityBiogerontology, 7
Z. Lippman, R. Martienssen (2004)
The role of RNA interference in heterochromatic silencingNature, 431
A. Muotri, V. Chu, M. Marchetto, Wei Deng, J. Moran, F. Gage (2005)
Somatic mosaicism in neuronal precursor cells mediated by L1 retrotranspositionNature, 435
(2004)
Tissue-specifi c elevated genomic cytosine methylation levels are associated with an overgrowth phenotype of bovine fetuses derived by in vitro techniques
K. Beckman, B. Ames (1999)
Endogenous oxidative damage of mtDNA.Mutation research, 424 1-2
Fabiola Daroch, M. Hoeneisen, Carlos González, F. Kawaguchi, F. Salgado, H. Solar, Apolinaria García (2001)
In vitro antibacterial activity of Chilean red wines against Helicobacter pylori.Microbios, 104 408
Preston Estep, M. Kaeberlein (2006)
Life Extension Pseudoscience and the SENS Plan
R. Cawthon, Ken Smith, E. O'Brien, A. Sivatchenko, R. Kerber (2003)
Association between telomere length in blood and mortality in people aged 60 years or olderThe Lancet, 361
N. Gilbert, Sheila Lutz-Prigge, J. Moran (2002)
Genomic Deletions Created upon LINE-1 RetrotranspositionCell, 110
M. Dollé, Heidi Giese, C. Hopkins, H. Martus, Jeffrey Hausdorff, J. Vijg (1997)
Rapid accumulation of genome rearrangements in liver but not in brain of old miceNature Genetics, 17
G. Martin (2005)
Epigenetic drift in aging identical twins.Proceedings of the National Academy of Sciences of the United States of America, 102 30
A. Wiley (1997)
Why We Get Sick: The New Science of Darwinian MedicineMedical Anthropology Quarterly, 11
S. Olshansky, D. Perry, Richard Miller, R. Butler (2006)
In pursuit of the longevity dividendThe Scientist, 20
D. Sinclair (2005)
Toward a unified theory of caloric restriction and longevity regulationMechanisms of Ageing and Development, 126
V. Anisimov, L. Berstein, P. Egormin, T. Piskunova, I. Popovich, M. Zabezhinski, I. Kovalenko, T. Poroshina, A. Semenchenko, M. Provinciali, F. Re, C. Franceschi (2005)
Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic miceExperimental Gerontology, 40
C. Allegrucci, A. Thurston, E. Lucas, L. Young (2005)
Epigenetics and the germline.Reproduction, 129 2
M. Dewannieux, Cécile Esnault, T. Heidmann (2003)
LINE-mediated retrotransposition of marked Alu sequencesNature Genetics, 35
P. Bennett-Baker, J. Wilkowski, D. Burke (2003)
Age-associated activation of epigenetically repressed genes in the mouse.Genetics, 165 4
T. Pugh, R. Klopp, R. Weindruch (1999)
Controlling caloric consumption: protocols for rodents and rhesus monkeys☆Neurobiology of Aging, 20
J. Baur, D. Sinclair (2006)
Therapeutic potential of resveratrol: the in vivo evidenceNature Reviews Drug Discovery, 5
J. Harper, C. Leathers, S. Austad (2006)
Does caloric restriction extend life in wild mice?Aging Cell, 5
R. Weindruch (2006)
Will dietary restriction work in primates?Biogerontology, 7
C. Martin-Ruiz, H. Dickinson, B. Keys, E. Rowan, R. Kenny, T. Zglinicki (2006)
Telomere length predicts poststroke mortality, dementia, and cognitive declineAnnals of Neurology, 60
G. Williams (1957)
PLEIOTROPY, NATURAL SELECTION, AND THE EVOLUTION OF SENESCENCEEvolution, 11
E. Bennett, Laura Coleman, Circe Tsui, W. Pittard, S. Devine (2004)
Natural Genetic Variation Caused by Transposable Elements in HumansGenetics, 168
(2002)
DNA damage and its processing
Vaag, Zarko Stephan, T. Spector, Yue-zhong Wu, C. Plass, M. Esteller, Boix-Chornet, A. Sánchez-Aguilera, C. Ling, E. Carlsson, P. Poulsen, Allan, Ballestar, D. Heine-Suñer, J. Cigudosa, M. Urioste, J. Benítez, Manuel, M. Fraga, E. Ballestar, M. Paz, S. Ropero, F. Setién (2005)
From The Cover : Epigenetic differences arise during the lifetime of monozygotic twins
B. Elliott, C. Richardson, M. Jasin (2005)
Chromosomal translocation mechanisms at intronic alu elements in mammalian cells.Molecular cell, 17 6
M. Kaeberlein, M. McVey, L. Guarente (1999)
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.Genes & development, 13 19
Cécile Esnault, J. Maestre, T. Heidmann (2000)
Human LINE retrotransposons generate processed pseudogenesNature Genetics, 24
M. Ravenel (1928)
Eat, Drink and be HealthyAmerican Journal of Public Health, 18
A. Lehmann (1989)
Trichothiodystrophy and the relationship between DNA repair and cancerBioEssays, 11
E. Ostertag, H. Kazazian (2001)
Biology of mammalian L1 retrotransposons.Annual review of genetics, 35
Richard Cutler (1991)
Recent progress in testing the longevity determinant and dysdifferentiation hypotheses of aging.Archives of gerontology and geriatrics, 12 2-3
B. Bernstein, Michael Kamal, K. Lindblad-Toh, S. Bekiranov, D. Bailey, Dana Huebert, Scott McMahon, E. Karlsson, E. Kulbokas, T. Gingeras, S. Schreiber, E. Lander (2005)
Genomic Maps and Comparative Analysis of Histone Modifications in Human and MouseCell, 120
(1858)
The deacon’s masterpiece or the wonderful one-hoss shay, A logical story
K. Beckman, S. Saljoughi, S. Mashiyama, B. Ames, B. Ames (2000)
A simpler, more robust method for the analysis of 8-oxoguanine in DNA.Free radical biology & medicine, 29 3-4
C. Mccay, M. Crowell, L. Maynard (1935)
The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935.Nutrition, 5 3
(1995)
Mother Nature is a wicked old witch !
(2006)
SENS challenge, response by Mobbs to de Grey’s rebuttal
J Messinger, J. Nugent, M. Evans, L Kulik, B. Epel, W. Lubitz, J. Messinger, J. Am, Chem, V Yachandra, K. Sauer, M. Klein, H. Chu, W. Hillier, N. Law, G. Båbcock, Biochim, K Ferreira, T. Iverson, K. Maghlaoui, J. Barber, J Biesiadka, B. Loll, J. Kern, K. Irrgang, A. Zouni, Phys, R Scott, J. Hahn, S. Doniach, H. Freeman, K. Hodgson, A Flank, M. Weininger, L. Mortenson, S. Cramer, R Debus, M. Strickler, L. Walker, B. Conti, M. Sánchez-Alavez, R. Winsky-Sommerer, María, Concetta Morale, J. Lucero, S. Brownell, V. Fabre, Salvador, Huitron-Resendiz, S. Henriksen, E. Zorrilla, L. Lecea, Bartfai
Supporting Online Material Material and Methods Som Text Figs. S1 to S7 Tables S1 and S2 References Transgenic Mice with a Reduced Core Body Temperature Have an Increased Life Span
L. Niedernhofer, G. Garinis, A. Raams, A. Lalai, A. Robinson, E. Appeldoorn, H. Odijk, R. Oostendorp, A. Ahmad, W. Leeuwen, A. Theil, W. Vermeulen, G. Horst, P. Meinecke, W. Kleijer, J. Vijg, N. Jaspers, J. Hoeijmakers (2006)
A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axisNature, 444
M. Dewannieux, T. Heidmann (2005)
LINEs, SINEs and processed pseudogenes: parasitic strategies for genome modelingCytogenetic and Genome Research, 110
A. Schouten, L. Wagemakers, F. Stefanato, R. Kaaij, J. Kan (2002)
Resveratrol acts as a natural profungicide and induces self‐intoxication by a specific laccaseMolecular Microbiology, 43
I. Conboy, M. Conboy, A. Wagers, Eric Girma, I. Weissman, T. Rando (2005)
Rejuvenation of aged progenitor cells by exposure to a young systemic environmentNature, 433
Tao Lu, Ying Pan, S. Kao, Cheng Li, I. Kohane, J. Chan, B. Yankner (2004)
Gene regulation and DNA damage in the ageing human brainNature, 429
Zhongde Wang, A. Meissner, R. Jaenisch (2004)
Nuclear Cloning and Epigenetic Reprogramming, 1
Cécile Esnault, O. Heidmann, Frédéric Delebecque, M. Dewannieux, D. Ribet, A. Hance, T. Heidmann, O. Schwartz (2005)
APOBEC3G cytidine deaminase inhibits retrotransposition of endogenous retrovirusesNature, 433
C. Walsh, JR Chaillet, T. Bestor (1998)
Transcription of IAP endogenous retroviruses is constrained by cytosine methylationNature Genetics, 20
M. Vermulst, J. Bielas, G. Kujoth, W. Ladiges, P. Rabinovitch, T. Prolla, L. Loeb (2007)
Mitochondrial point mutations do not limit the natural lifespan of miceNature Genetics, 39
Jason Wood, B. Rogina, Siva Lavu, K. Howitz, S. Helfand, M. Tatar, David Sinclair (2004)
Sirtuin activators mimic caloric restriction and delay ageing in metazoansNature, 430
R. Jaenisch (2004)
Human cloning - the science and ethics of nuclear transplantation.The New England journal of medicine, 351 27
Boris Vanyushin (2005)
Enzymatic DNA Methylation Is an Epigenetic Control for Genetic Functions of the CellBiochemistry (Moscow), 70
J. Mattison, G. Roth, M. Lane, D. Ingram (2007)
Dietary restriction in aging nonhuman primates.Interdisciplinary topics in gerontology, 35
R. Holliday (2005)
DNA Methylation and EpigenotypesBiochemistry (Moscow), 70
P. Medawar (1953)
UNSOLVED problem of biology.The Medical journal of Australia, 1 24
E. Stewart, R. Madden, Grégory Paul, F. Taddei (2005)
Aging and Death in an Organism That Reproduces by Morphologically Symmetric DivisionPLoS Biology, 3
Johannes Trapp, M. Jung (2006)
The role of NAD+ dependent histone deacetylases (sirtuins) in ageing.Current drug targets, 7 11
Jian-Min Chen, P. Stenson, D. Cooper, C. Férec (2005)
A systematic analysis of LINE-1 endonuclease-dependent retrotranspositional events causing human genetic diseaseHuman Genetics, 117
V. Anisimov, A. Semenchenko, A. Yashin (2004)
Insulin and longevity: antidiabetic biguanides as geroprotectorsBiogerontology, 4
H. Kazazian (1999)
An estimated frequency of endogenous insertional mutations in humansNature Genetics, 22
A. Grey (2003)
An engineer's approach to the development of real anti-aging medicine.Science of aging knowledge environment : SAGE KE, 2003 1
E. Teugels, S. Brakeleer, G. Goelen, W. Lissens, E. Sermijn, J. Grève (2005)
De novo Alu element insertions targeted to a sequence common to the BRCA1 and BRCA2 genesHuman Mutation, 26
Aubrey Grey (2005)
Resistance to debate on how to postpone ageing is delaying progress and costing lives
M. Sobrier, I. Netchine, C. Heinrichs, N. Thibaud, Marie-Pierre Vié-Luton, G. Vliet, S. Amselem (2005)
Alu‐element insertion in the homeodomain of HESX1 and aplasia of the anterior pituitaryHuman Mutation, 25
Jian-Min Chen, N. Chuzhanova, P. Stenson, C. Férec, D. Cooper (2005)
Meta‐Analysis of gross insertions causing human genetic disease: Novel mutational mechanisms and the role of replication slippageHuman Mutation, 25
J. Phelan, M. Rose (2005)
Why dietary restriction substantially increases longevity in animal models but won’t in humansAgeing Research Reviews, 4
M. Kuro-o, Y. Matsumura, H. Aizawa, H. Kawaguchi, T. Suga, T. Utsugi, Y. Ohyama, M. Kurabayashi, T. Kaname, E. Kume, H. Iwasaki, A. Iida, T. Shiraki-Iida, S. Nishikawa, R. Nagai, Y. Nabeshima (1997)
Mutation of the mouse klotho gene leads to a syndrome resembling ageingNature, 390
(2005)
Identifi cation of potential caloric restriction mimetics by microarray profi ling
P. Medawar (2008)
The Definition and Measurement of Senescence
M. Dewannieux, T. Heidmann (2005)
Role of poly(A) tail length in Alu retrotransposition.Genomics, 86 3
F. Eckhardt, Joern Lewin, R. Cortese, V. Rakyan, J. Attwood, M. Burger, J. Burton, Tony Cox, R. Davies, T. Down, C. Haefliger, R. Horton, K. Howe, D. Jackson, Jan Kunde, Christoph Koenig, J. Liddle, D. Niblett, T. Otto, Roger Pettett, S. Seemann, C. Thompson, Tony West, J. Rogers, A. Olek, K. Berlin, S. Beck (2006)
DNA methylation profiling of human chromosomes 6, 20 and 22Nature genetics, 38
D. Shumaker, T. Dechat, A. Kohlmaier, S. Adam, Matthew Bozovsky, M. Erdos, M. Eriksson, A. Goldman, S. Khuon, F. Collins, T. Jenuwein, R. Goldman (2006)
Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging.Proceedings of the National Academy of Sciences of the United States of America, 103 23
LSU Digital Commons LSU Digital Commons Mammalian retroelements Mammalian retroelements
Hau Liu, D. Bravata, I. Olkin, S. Nayak, Brian Roberts, A. Garber, A. Hoffman (2007)
Systematic Review: The Safety and Efficacy of Growth Hormone in the Healthy ElderlyAnnals of Internal Medicine, 146
D. Joravsky (1972)
The Lysenko Affair
R. Singhal, L. Mays-Hoopes, G. Eichhorn (1987)
DNA methylation in aging of miceMechanisms of Ageing and Development, 41
Jiaqiang Huang, Tao Fan, Q. Yan, Heming Zhu, Stephen Fox, H. Issaq, L. Best, L. Gangi, D. Munroe, K. Muegge (2004)
Lsh, an epigenetic guardian of repetitive elements.Nucleic acids research, 32 17
H. Warner, J. Anderson, S. Austad, E. Bergamini, D. Bredesen, R. Butler, B. Carnes, B. Clark, Vincent Cristofalo, John Faulkner, L. Guarente, D. Harrison, T. Kirkwood, G. Lithgow, George Martin, E. Masoro, S. Melov, Richard Miller, S. Olshansky, L. Partridge, O. Pereira-smith, T. Perls, A. Richardson, James Smith, T. Zglinicki, E. Wang, Jeanne Wei, T. Williams (2005)
Science fact and the SENS agendaEMBO reports, 6
B. Dasgupta, J. Milbrandt (2007)
Resveratrol stimulates AMP kinase activity in neuronsProceedings of the National Academy of Sciences, 104
D. Abrous, M. Koehl, M. Moal (2005)
Adult neurogenesis: from precursors to network and physiology.Physiological reviews, 85 2
S. Giampaoli (2000)
Epidemiology of major age-related diseases in women compared to menAging Clinical and Experimental Research, 12
T. Pugh, T. Oberley, R. Weindruch (1999)
Dietary intervention at middle age: caloric restriction but not dehydroepiandrosterone sulfate increases lifespan and lifetime cancer incidence in mice.Cancer research, 59 7
R. Jaenisch, K. Hochedlinger, K. Eggan (2005)
Nuclear cloning, epigenetic reprogramming and cellular differentiation.Novartis Foundation symposium, 265
K. Howitz, Kevin Bitterman, H. Cohen, Dudley Lamming, Siva Lavu, Jason Wood, R. Zipkin, Phuong Chung, A. Kisielewski, Li-li Zhang, Brandy Scherer, D. Sinclair (2003)
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespanNature, 425
V. Wilson, P. Jones (1983)
DNA methylation decreases in aging but not in immortal cells.Science, 220 4601
J. Issa (2003)
Age-related epigenetic changes and the immune system.Clinical immunology, 109 1
J. Issa (2002)
Epigenetic variation and human disease.The Journal of nutrition, 132 8 Suppl
L. Lavie, M. Kitova, E. Maldener, E. Meese, J. Mayer (2005)
CpG Methylation Directly Regulates Transcriptional Activity of the Human Endogenous Retrovirus Family HERV-K(HML-2)Journal of Virology, 79
F. Chaves, J. Real, A. García-García, O. Puig, J. Ordovás, J. Ascaso, R. Carmena, M. Armengod (2001)
Large rearrangements of the LDL receptor gene and lipid profile in a FH Spanish populationEuropean Journal of Clinical Investigation, 31
Paola Scaffidi, T. Misteli (2006)
Lamin A-Dependent Nuclear Defects in Human AgingScience, 312
A. Grey, B. Ames, J. Andersen, A. Bartke, J. Campisi, C. Heward, R. McCARTER, Gregory Stock (2002)
Time to Talk SENS: Critiquing the Immutability of Human AgingAnnals of the New York Academy of Sciences, 959
Hugo Kesteloot, X. Huang (2002)
On the relationship between human all-cause mortality and ageEuropean Journal of Epidemiology, 18
Paola Scaffidi, T. Misteli (2005)
Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndromeNature Medicine, 11
M. Goto (1997)
Hierarchical deterioration of body systems in Werner's syndrome: Implications for normal ageingMechanisms of Ageing and Development, 98
R. Holliday (2006)
Aging is No Longer an Unsolved Problem in BiologyAnnals of the New York Academy of Sciences, 1067
Baohua Liu, Jianming Wang, K. Chan, W. Tjia, W. Deng, Xinyuan Guan, Jian-Dong Huang, Kai Li, Pui Chau, David Chen, D. Pei, A. Pendás, J. Cadiñanos, C. López-Otín, H. Tse, C. Hutchison, Junjie Chen, Yihai Cao, K. Cheah, K. Tryggvason, Zhongjun Zhou (2005)
Genomic instability in laminopathy-based premature agingNature Medicine, 11
D. Wells (2005)
Animal cloning: problems and prospects.Revue scientifique et technique, 24 1
C. Finch (1990)
Longevity, senescence, and the genome
Giuseppina Giglia-Mari, F. Coin, J. Ranish, D. Hoogstraten, A. Theil, N. Wijgers, N. Jaspers, A. Raams, M. Argentini, P. Spek, E. Botta, M. Stefanini, J. Egly, R. Aebersold, J. Hoeijmakers, W. Vermeulen (2004)
A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group ANature Genetics, 36
R. Ohlsson (2004)
Loss of IGF2 imprinting: mechanisms and consequences.Novartis Foundation symposium, 262
M. Puzianowska-Kuźnicka, J. Kuźnicki (2005)
Genetic alterations in accelerated ageing syndromes. Do they play a role in natural ageing?The international journal of biochemistry & cell biology, 37 5
K. Muegge (2005)
Lsh, a guardian of heterochromatin at repeat elements.Biochemistry and cell biology = Biochimie et biologie cellulaire, 83 4
M. Dollé, Wendy Snyder, Jan Gossen, P. Lohman, Jan Vijg (2000)
Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine.Proceedings of the National Academy of Sciences of the United States of America, 97 15
L. Szilard (1959)
ON THE NATURE OF THE AGING PROCESS.Proceedings of the National Academy of Sciences of the United States of America, 45 1
David Humpherys, K. Eggan, H. Akutsu, K. Hochedlinger, W. Rideout, D. Biniszkiewicz, R. Yanagimachi, R. Jaenisch (2001)
Epigenetic Instability in ES Cells and Cloned MiceScience, 293
Q. Yan, Jiaqiang Huang, Tao Fan, Heming Zhu, K. Muegge (2003)
Lsh, a modulator of CpG methylation, is crucial for normal histone methylationThe EMBO Journal, 22
J. Román-Gómez, A. Jiménez-Velasco, X. Agirre, F. Cervantes, Joaquín Sánchez, L. Gárate, M. Barrios, J. Castillejo, G. Navarro, D. Colomer, F. Prósper, A. Heiniger, A. Torres (2005)
Promoter hypomethylation of the LINE-1 retrotransposable elements activates sense/antisense transcription and marks the progression of chronic myeloid leukemiaOncogene, 24
R. Hennekam (2006)
Hutchinson–Gilford progeria syndrome: Review of the phenotypeAmerican Journal of Medical Genetics Part A, 140A
E. Lander, L. Linton, B. Birren, C. Nusbaum, M. Zody, J. Baldwin, K. Devon, K. Dewar, M. Doyle, W. Fitzhugh, R. Funke, D. Gage, K. Harris, A. Heaford, J. Howland, L. Kann, J. Lehoczky, R. Levine, P. McEwan, K. McKernan, J. Meldrim, J. Mesirov, C. Miranda, W. Morris, J. Naylor, C. Raymond, M. Rosetti, R. Santos, A. Sheridan, C. Sougnez, Y. Stange-Thomann, N. Stojanovic, A. Subramanian, D. Wyman, J. Rogers, J. Sulston, R. Ainscough, S. Beck, D. Bentley, J. Burton, C. Clee, N. Carter, A. Coulson, R. Deadman, P. Deloukas, A. Dunham, I. Dunham, R. Durbin, L. French, D. Grafham, S. Gregory, T. Hubbard, S. Humphray, A. Hunt, M. Jones, C. Lloyd, A. McMurray, L. Matthews, S. Mercer, S. Milne, J. Mullikin, A. Mungall, R. Plumb, M. Ross, R. Shownkeen, S. Sims, R. Waterston, R. Wilson, L. Hillier, J. McPherson, M. Marra, E. Mardis, L. Fulton, A. Chinwalla, K. Pepin, W. Gish, S. Chissoe, M. Wendl, K. Delehaunty, T. Miner, A. Delehaunty, J. Kramer, L. Cook, R. Fulton, D. Johnson, P. Minx, S. Clifton, T. Hawkins, E. Branscomb, P. Predki, P. Richardson, S. Wenning, T. Slezak, N. Doggett, J. Cheng, A. Olsen, S. Lucas, C. Elkin, E. Uberbacher, M. Frazier, R. Gibbs, D. Muzny, S. Scherer, J. Bouck, E. Sodergren, K. Worley, C. Rives, J. Gorrell, M. Metzker, S. Naylor, R. Kucherlapati, D. Nelson, G. Weinstock, Y. Sakaki, A. Fujiyama, M. Hattori, T. Yada, A. Toyoda, T. Itoh, C. Kawagoe, H. Watanabe, Y. Totoki, T. Taylor, J. Weissenbach, R. Heilig, W. Saurin, F. Artiguenave, P. Brottier, T. Bruls, É. Pelletier, C. Robert, P. Wincker, D. Smith, L. Doucette-Stamm, M. Rubenfield, K. Weinstock, H. Lee, J. Dubois, A. Rosenthal, M. Platzer, G. Nyakatura, S. Taudien, A. Rump, H. Yang, J. Yu, J. Wang, G. Huang, J. Gu, L. Hood, L. Rowen, A. Madan, S. Qin, R. Davis, N. Federspiel, A. Abola, M. Proctor, R. Myers, J. Schmutz, M. Dickson, J. Grimwood, D. Cox, M. Olson, R. Kaul, N. Shimizu, K. Kawasaki, S. Minoshima, G. Evans, M. Athanasiou, R. Schultz, B. Roe, F. Chen, H. Pan, J. Ramser, H. Lehrach, R. Reinhardt, W. McCombie, M. Bastide, N. Dedhia, H. Blöcker, K. Hornischer, G. Nordsiek, R. Agarwala, L. Aravind, J. Bailey, A. Bateman, S. Batzoglou, E. Birney, P. Bork, D. Brown, C. Burge, L. Cerutti, H. Chen, D. Church, M. Clamp, R. Copley, T. Doerks, S. Eddy, E. Eichler, T. Furey, J. Galagan, J. Gilbert, C. Harmon, Y. Hayashizaki, D. Haussler, H. Hermjakob, K. Hokamp, W. Jang, L. Johnson, T. Jones, S. Kasif, A. Kaspryzk, S. Kennedy, W. Kent, P. Kitts, E. Koonin, I. Korf, D. Kulp, D. Lancet, Gwênlyn Glusman, T. Lowe, A. McLysaght, T. Mikkelsen, J. Moran, N. Mulder, V. Pollara, C. Ponting, G. Schuler, J. Schultz, G. Slater, A. Smit, E. Stupka, J. Szustakowki, D. Thierry-Mieg, J. Thierry-Mieg, L. Wagner, J. Wallis, R. Wheeler, A. Williams, Y. Wolf, K. Wolfe, S. Yang, R. Yeh, F. Collins, M. Guyer, J. Peterson, A. Felsenfeld, K. Wetterstrand, A. Patrinos, M. Morgan, P. Jong, J. Catanese, K. Osoegawa, H. Shizuya, S. Choi, Y. Chen, Vacslav Glukhov (2001)
Initial sequencing and analysis of the human genome.Nature, 409 6822
Melinda Ramsey, J. Weiner, Tracy Moore, C. Carter, W. Sonntag (2004)
Growth hormone treatment attenuates age-related changes in hippocampal short-term plasticity and spatial learningNeuroscience, 129
R. Holliday (2004)
Human ageing and the origins of religionBiogerontology, 2
(2005)
Oxidative DNA modifi cations. Experimental and Toxicologic Pathology
D. Arking, G. Atzmon, A. Arking, N. Barzilai, H. Dietz (2005)
Association Between a Functional Variant of the KLOTHO Gene and High-Density Lipoprotein Cholesterol, Blood Pressure, Stroke, and LongevityCirculation Research, 96
L. Menendez, B. Benigno, J. McDonald (2004)
L1 and HERV-W retrotransposons are hypomethylated in human ovarian carcinomasMolecular Cancer, 3
T. Bestor (1998)
The host defence function of genomic methylation patterns.Novartis Foundation symposium, 214
T. Kohda, K. Inoue, N. Ogonuki, H. Miki, M. Naruse, T. Kaneko-Ishino, A. Ogura, F. Ishino (2005)
Variation in Gene Expression and Aberrantly Regulated Chromosome Regions in Cloned Mice1, 73
Richard Miller, C. Chrisp (1999)
Lifelong Treatment with Oral DHEA Sulfate Does Not Preserve Immune Function, Prevent Disease, or Improve Survival in Genetically Heterogeneous MiceJournal of the American Geriatrics Society, 47
CHAPTER 3 The Promise of Human Life Span Extension Preston W. Estep III The eminent evolutionary biologist George C. Williams once famously en- titled a publication “Mother Nature is a wicked old witch!” in which he de- scribed the effi cient brutality of natural selection as morally reprehensible (Williams, 1995). Williams rightly thought that one of the most brutal and unforgiving selective acts is death itself, although he thought it unavoidable (Nesse & Williams, 1996). Throughout history, humans have had no real con- trol over senescence and death, and, to deal with this ever-present burden, they have turned to various diversions and increasingly elaborate mythmaking (Holliday, 2001). We still do not have a clear overall physiological model of the senescent mechanisms that lead ultimately to death, but evolutionary biol- ogy and gerontology have made impressive progress in understanding many aspects of this process. In theory, there is no known physical law or other scientifi c barrier to prevent complete control over senescence and death. Despite the absence of proof that death is an immutable part of human life, there is an equal absence of proof that it can be controlled to this degree. From our current perspective, the known
Annual Review of Gerontology & Geriatrics – Springer Publishing
Published: Jan 1, 2007
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