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The Effect of Aging on the Immune Response

The Effect of Aging on the Immune Response CHAPTER 1 The Effect of Aging on the Immune Response GREGORY W. SISKIND, M.D., and MARC E. WEKSLER, M.D. DEPARTMENT OF MEDTCINE CORNELL UNIVERSITY MEDICAL COLLEGE NEW YORK, NEW YORK INTRODUCTION TMs review attempts to place in perspective a large body of knowledge concerning immune senescence. We have not attempted to offer an encyclopedic compilation of the literature, Rather, we havc made a synthesis of data from our own laboratory and the laboratories of other investigators which is germam to the hypothesis that the involution of the thymus after sexual maturity plays a critical role in the senescence of the immune system. We have discussed in detaiI results of clinical studies and have employed studies in experimentai animals to extend and amplify mndusions drawn fram investigations in man, THYMIC INVOLUTION AND AGING The involution of the thymus after puberty was recognized Iong before the immunologic function of the organ was discovered. In the early 1930s careful anatomical studies showed that the mass of the human The work of the authors which in described here was supported by grants from National lnstitutcs of Health, USPHS numbers: A1 11694, CA 20Ln5. CA 13339, CA 26344. AC W9, and AG 00541. BIOLOGEAL http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Gerontology & Geriatrics Springer Publishing

The Effect of Aging on the Immune Response

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Publisher
Springer Publishing
ISSN
0198-8794
eISSN
1944-4036
DOI
10.1891/0198-8794.3.1.3
Publisher site
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Abstract

CHAPTER 1 The Effect of Aging on the Immune Response GREGORY W. SISKIND, M.D., and MARC E. WEKSLER, M.D. DEPARTMENT OF MEDTCINE CORNELL UNIVERSITY MEDICAL COLLEGE NEW YORK, NEW YORK INTRODUCTION TMs review attempts to place in perspective a large body of knowledge concerning immune senescence. We have not attempted to offer an encyclopedic compilation of the literature, Rather, we havc made a synthesis of data from our own laboratory and the laboratories of other investigators which is germam to the hypothesis that the involution of the thymus after sexual maturity plays a critical role in the senescence of the immune system. We have discussed in detaiI results of clinical studies and have employed studies in experimentai animals to extend and amplify mndusions drawn fram investigations in man, THYMIC INVOLUTION AND AGING The involution of the thymus after puberty was recognized Iong before the immunologic function of the organ was discovered. In the early 1930s careful anatomical studies showed that the mass of the human The work of the authors which in described here was supported by grants from National lnstitutcs of Health, USPHS numbers: A1 11694, CA 20Ln5. CA 13339, CA 26344. AC W9, and AG 00541. BIOLOGEAL

Journal

Annual Review of Gerontology & Geriatrics – Springer Publishing

Published: Sep 1, 1982

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