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CHAPTER 4 Role of Endogenous Proteins as Negative Growth Modulators During In Vitro Cellular Aging of Human Diploid Fibroblasts MARY BETH PORTER AND JAM ES R. SMITH BAYLOR COLLEGE Of MEDI CINE Aging is a normal part of development, yet many aspects of the aging process are not understood. Overall, people lend to age in a simi lar fashion (e,g. graying hair), but not everyone ha s all the same characteristics of aging, nor do people age al the same rate. As a result. it is difficult to define agi ng precisely and develop model s to ask relevant question s as 10 how and why we age. CELLULAR MODEL OF AGING A signifi cant eve nt occurred in 1961 thaI a ll owed development of a human cellular model to study aging. Hayflick and Moorhead (1961) reported in an exlensive study that normal human diploid fibroblasts exhibited a limited life span when grown in tissue culture. The ce lls go through a defined number of popu lation doubl ings and then cease to divide. They demonstrated that this loss of proliferative ability was not due to c ulture conditions or other artifacts . In fact , senescent cells
Annual Review of Gerontology & Geriatrics – Springer Publishing
Published: Jan 1, 1990
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