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Diseases of Carbohydrate and Lipid Metabolism

Diseases of Carbohydrate and Lipid Metabolism Diseases of Carbohydrate and Lipid Metabolism EDWIN L. BIERMAN, M.D. DBPAR~ENT OF MEDICINE UHWERSlTY OF WASHLNGTON SEU~LE, WASHINGTON This review wiU focus on recent advances in carbohydrate and lipid metabolism as aected by aging, with particular emphasis on associated metabolic disorders such as diabetes mellitus, obesity, and the hyper- Iipidemias. DIABETES MELLlTUS AND CARBOffYDRATE METABOLISM Evidence is accumulating &at accelerated aging or senescence charac- terizes the human diabetic state and its complications (Vracko and Ben- ditt, 1974). Primary abnormalities related to aging may be on a genetic basis, expressed in dl cells, and they may be exaggerated by hyper- glycemia. Accelerated aging in tissues may be manifested by decreased replication of beta cells of the pancreatic islets in response to injury and accelerated rate of cell death of mendothelial cells in capillaries leadiig to diabetic microangiopatby. Aging of cells can be detected in tissue culture of skin fibroblasts from diabetic patients by decreased replication rates and life span in culture (Vracko and Benditt, 1975; Goldstein et al., 1978; Gleason and Goldstein, 1978; Goldstein et al., 1979; Rowe et al., 1977). me width of muscle capillary basement membrane increases with age in healthy subjects and this thickening is accelerated in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Gerontology & Geriatrics Springer Publishing

Diseases of Carbohydrate and Lipid Metabolism

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Publisher
Springer Publishing
ISSN
0198-8794
eISSN
1944-4036
DOI
10.1891/0198-8794.1.1.154
Publisher site
See Article on Publisher Site

Abstract

Diseases of Carbohydrate and Lipid Metabolism EDWIN L. BIERMAN, M.D. DBPAR~ENT OF MEDICINE UHWERSlTY OF WASHLNGTON SEU~LE, WASHINGTON This review wiU focus on recent advances in carbohydrate and lipid metabolism as aected by aging, with particular emphasis on associated metabolic disorders such as diabetes mellitus, obesity, and the hyper- Iipidemias. DIABETES MELLlTUS AND CARBOffYDRATE METABOLISM Evidence is accumulating &at accelerated aging or senescence charac- terizes the human diabetic state and its complications (Vracko and Ben- ditt, 1974). Primary abnormalities related to aging may be on a genetic basis, expressed in dl cells, and they may be exaggerated by hyper- glycemia. Accelerated aging in tissues may be manifested by decreased replication of beta cells of the pancreatic islets in response to injury and accelerated rate of cell death of mendothelial cells in capillaries leadiig to diabetic microangiopatby. Aging of cells can be detected in tissue culture of skin fibroblasts from diabetic patients by decreased replication rates and life span in culture (Vracko and Benditt, 1975; Goldstein et al., 1978; Gleason and Goldstein, 1978; Goldstein et al., 1979; Rowe et al., 1977). me width of muscle capillary basement membrane increases with age in healthy subjects and this thickening is accelerated in

Journal

Annual Review of Gerontology & GeriatricsSpringer Publishing

Published: Sep 1, 1980

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