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Assessing Outcomes of Psychopharmacological Treatments in the Elderly: Evolving Considerations for Research and Clinical Practice

Assessing Outcomes of Psychopharmacological Treatments in the Elderly: Evolving Considerations... CHAPTER 2 Assessing Outcomes of Psychopharmacological Treatments in the Elderly: Evolving Considerations for Research and Clinical Practice JOE L E. STR E(M GERIATR IC P SYC HI ATRY UNIVERSITY OF PENNSYLVANIA INTRODUCTION Over the past few years, the research litera ture has reflected a broad er range o f concerns abou t assessing outcomes o f drug treatme nt in geriatric pat ients. Di lem mas in measuring the outco mes of psychopharmacologic interventions in o lder ad ults ha ve been addressed m os t in tensively by investigators w h o s t u d y degenerative dementia an d late- life d ep ression. This chapter explores key issues in outcome assessment, includin g the determinants of cl ini cal releva nce, th e expand ing range of d o main s to b e measured, indicators and parameters o f positive response, safety and to l­ erability considera ti ons, and confou ndin g effects. Recent progress in thi s area is summ ar i:-;ed a n d d iscu ssed. . DETERMINANTS OF CLINICAL RELEVANCE One of the greatest challen ges to in ves ti ga tors is the need to ascertain wh ich http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Gerontology & Geriatrics Springer Publishing

Assessing Outcomes of Psychopharmacological Treatments in the Elderly: Evolving Considerations for Research and Clinical Practice

Annual Review of Gerontology & Geriatrics , Volume 19 (1): 24 – Jan 1, 1999

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Publisher
Springer Publishing
ISSN
0198-8794
eISSN
1944-4036
DOI
10.1891/0198-8794.19.1.13
Publisher site
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Abstract

CHAPTER 2 Assessing Outcomes of Psychopharmacological Treatments in the Elderly: Evolving Considerations for Research and Clinical Practice JOE L E. STR E(M GERIATR IC P SYC HI ATRY UNIVERSITY OF PENNSYLVANIA INTRODUCTION Over the past few years, the research litera ture has reflected a broad er range o f concerns abou t assessing outcomes o f drug treatme nt in geriatric pat ients. Di lem mas in measuring the outco mes of psychopharmacologic interventions in o lder ad ults ha ve been addressed m os t in tensively by investigators w h o s t u d y degenerative dementia an d late- life d ep ression. This chapter explores key issues in outcome assessment, includin g the determinants of cl ini cal releva nce, th e expand ing range of d o main s to b e measured, indicators and parameters o f positive response, safety and to l­ erability considera ti ons, and confou ndin g effects. Recent progress in thi s area is summ ar i:-;ed a n d d iscu ssed. . DETERMINANTS OF CLINICAL RELEVANCE One of the greatest challen ges to in ves ti ga tors is the need to ascertain wh ich

Journal

Annual Review of Gerontology & GeriatricsSpringer Publishing

Published: Jan 1, 1999

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