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Aging and Renal Function

Aging and Renal Function JOHN W. ROW, M.D. HA~VARD MEDICAL SCHOOL BOSTON, ~SACWSBTTS The goal of tbis chapter is to provide an overview of the changes in mammalian renal function that occur in adult life. Emphasis will be on morphology and physiology, including a detailed discussion of adaptive mechanisms responsible for the regulation of volume and composition of the extracellular fluid. Where pertinent, the clinical impact of the norma- tive age-related changes in renal function will be explored. In the ha1 section, available information on specific primary renal diseases in which presentation, course, or comphcations are iduenced by age will be presented. The term aging, as used here, refers to changes that occur after attainment of maturity, and in the absence of disease states. Changes prior to maturity-during childhood and adolescence-are properly in- cluded in the area of growth and development rather than senescence and will not be discussed. There are two major difficulties with the presently available literature on renal function and age. The first is the rather marked species variation. Commonly employed strains of laboratory rats develop glomerulonephritis with age, and although the mechanism underlying this alteration is of con- siderable biologic interest, it weakens the utility of the rat as http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Gerontology & Geriatrics Springer Publishing

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Publisher
Springer Publishing
ISSN
0198-8794
eISSN
1944-4036
DOI
10.1891/0198-8794.1.1.161
Publisher site
See Article on Publisher Site

Abstract

JOHN W. ROW, M.D. HA~VARD MEDICAL SCHOOL BOSTON, ~SACWSBTTS The goal of tbis chapter is to provide an overview of the changes in mammalian renal function that occur in adult life. Emphasis will be on morphology and physiology, including a detailed discussion of adaptive mechanisms responsible for the regulation of volume and composition of the extracellular fluid. Where pertinent, the clinical impact of the norma- tive age-related changes in renal function will be explored. In the ha1 section, available information on specific primary renal diseases in which presentation, course, or comphcations are iduenced by age will be presented. The term aging, as used here, refers to changes that occur after attainment of maturity, and in the absence of disease states. Changes prior to maturity-during childhood and adolescence-are properly in- cluded in the area of growth and development rather than senescence and will not be discussed. There are two major difficulties with the presently available literature on renal function and age. The first is the rather marked species variation. Commonly employed strains of laboratory rats develop glomerulonephritis with age, and although the mechanism underlying this alteration is of con- siderable biologic interest, it weakens the utility of the rat as

Journal

Annual Review of Gerontology & GeriatricsSpringer Publishing

Published: Sep 1, 1980

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