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Aging and Basal Gangliar Functions

Aging and Basal Gangliar Functions CHAPTER 2 CALEB E. FINCH, PH.D PATRICK K. RANDALL, PH.D THE ANDRUS GERONTOLOGY CENTER UNIVERSITY OF SOUTHERN CALIFORNIA Los ANGELES, CALIFORNIA The mammalian basal ganglia are importantly involved in the regulation of movement. After maturity, these brain regions undergo age changes in their structure and neurochemistry which can profoundly affect the behav- ior and drug responses of aging animals and humans. The structures of the basal ganglia, which include the substantia nigra, caudate-put amen (neostriatum), and globus pallidus, are richly interconnected (Figure 2- 1). By virtue of the neocorticai information that they receive and their influence on the motor cortex (through the ventral thalamus), the basal ganglia are well situated to process sensory information and modify sig- nals sent to the neurons of the pyramidal tracts. The cell bodies of pyra- midal tract neurons are in the motor cortex and send direct pathways to spinal chord rnotoneurons controlling the skeletal muscles (Truex and Carpenter, 1969; Papeschi, 1972; Lewis, 1976; Ganong, 1977). Age changes in the basal ganglia are of much current interest because of their suspected involvement in some of the movement disorders of The research of the authors was supported by the following grants: CEF (NIA. AG-00117. AG-W446); http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Gerontology & Geriatrics Springer Publishing

Aging and Basal Gangliar Functions

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References (114)

Publisher
Springer Publishing
ISSN
0198-8794
eISSN
1944-4036
DOI
10.1891/0198-8794.2.1.49
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Abstract

CHAPTER 2 CALEB E. FINCH, PH.D PATRICK K. RANDALL, PH.D THE ANDRUS GERONTOLOGY CENTER UNIVERSITY OF SOUTHERN CALIFORNIA Los ANGELES, CALIFORNIA The mammalian basal ganglia are importantly involved in the regulation of movement. After maturity, these brain regions undergo age changes in their structure and neurochemistry which can profoundly affect the behav- ior and drug responses of aging animals and humans. The structures of the basal ganglia, which include the substantia nigra, caudate-put amen (neostriatum), and globus pallidus, are richly interconnected (Figure 2- 1). By virtue of the neocorticai information that they receive and their influence on the motor cortex (through the ventral thalamus), the basal ganglia are well situated to process sensory information and modify sig- nals sent to the neurons of the pyramidal tracts. The cell bodies of pyra- midal tract neurons are in the motor cortex and send direct pathways to spinal chord rnotoneurons controlling the skeletal muscles (Truex and Carpenter, 1969; Papeschi, 1972; Lewis, 1976; Ganong, 1977). Age changes in the basal ganglia are of much current interest because of their suspected involvement in some of the movement disorders of The research of the authors was supported by the following grants: CEF (NIA. AG-00117. AG-W446);

Journal

Annual Review of Gerontology & Geriatrics – Springer Publishing

Published: Jan 1, 1981

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