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Zinc balance normalization



© Copyright 2007 by Humana Press Inc. All rights of any nature, whatsoever, reserved. 0163-4984/(Online) 1559-0720/07/11503–0223 $30.00 An Important Mechanism of Angiotensin-Converting Enzyme Inhibitors and Other Drugs Decreasing the Activity of the Rennin–Angiotensin–Aldosterone System ⁄ SLAWOMIR TUBEK Faculty of Physical Education and Physiotherapy, Institute of Technology, Opole, and Clinic of Cardiology, Medical Academy, Wrocl⁄aw, Prószkowska Street 76, 45-758 Opole, Poland Received May 22, 2006; Accepted June 10, 2006 Imbalances of zinc (Zn) metabolism in arterial hypertension are related to increased urinary Zn excretion, Zn transfer between extracellular and intracellular spaces, and redistribution of this element inside the cells. The changes include an increase of the absorption of Zn in the gastrointestinal tract and decreases of its concentration in lymphocytes, bone, and arterial walls. The Zn content of erythrocytes, cardiac muscle, and kidneys also increases. The condition eventually leads to Zn deficiency (1–5). Zinc plays many roles in biological systems. It is a component of over 300 enzymes, performing catalytic, cocatalytic, and/or structural functions. Among others, it conditions the activities of carbonic anhydrase (CA) and the angiotensin-I converting (ACE) and endothelin-converting (EC) enzymes. Zn is essential for forming the quaternary structure of numerous regulatory proteins and hormone receptors that



Biological Trace Element ResearchSpringer Journals

Published: Mar 1, 2007

DOI: 10.1007/BF02685997

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