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- Publisher
- Springer Journals
- Copyright
- Copyright © 2008 by Springer-Verlag
- Subject
- Biomedicine; Pharmacology/Toxicology
- ISSN
- 0031-6970
- eISSN
- 1432-1041
- DOI
- 10.1007/s00228-008-0468-8
- pmid
- 18320183
- Publisher site
- See Article on Publisher Site
Abstract
Participants in phase I studies are a self-selected sample defined by low trait-anxiety and social avoidance behaviors. This self-selection bias may affect the study results because less anxious subjects tend to report fewer adverse events. The characterization of a participant’s personality traits may be important in phase I studies.
Journal
European Journal of Clinical Pharmacology – Springer Journals
Published: Mar 5, 2008