These experiments evaluate overexpression of basic fibroblast growth factor (FGF-2) as a treatment to decrease photoreceptor cell death in the constant light damage model of retinal degeneration. Increased FGF-2 expression was accomplished by gene transfer to the retina via injection into the subretinal space of a recombinant adeno-associated virus (rAAV), containing the FGF-2 gene. Rescue effects were assessed by morphometry and electroretinographic analysis.
Documenta Ophthalmologica – Springer Journals
Published: Oct 6, 2004
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