Viral-mediated FGF-2 treatment of the constant light damage model of photoreceptor degeneration

Viral-mediated FGF-2 treatment of the constant light damage model of photoreceptor degeneration These experiments evaluate overexpression of basic fibroblast growth factor (FGF-2) as a treatment to decrease photoreceptor cell death in the constant light damage model of retinal degeneration. Increased FGF-2 expression was accomplished by gene transfer to the retina via injection into the subretinal space of a recombinant adeno-associated virus (rAAV), containing the FGF-2 gene. Rescue effects were assessed by morphometry and electroretinographic analysis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Documenta Ophthalmologica Springer Journals

Viral-mediated FGF-2 treatment of the constant light damage model of photoreceptor degeneration

Documenta Ophthalmologica, Volume 106 (1) – Oct 6, 2004

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Publisher
Springer Journals
Copyright
Copyright © 2003 by Kluwer Academic Publishers
Subject
Medicine & Public Health; Ophthalmology
ISSN
0012-4486
eISSN
1573-2622
D.O.I.
10.1023/A:1022481306146
Publisher site
See Article on Publisher Site

Abstract

These experiments evaluate overexpression of basic fibroblast growth factor (FGF-2) as a treatment to decrease photoreceptor cell death in the constant light damage model of retinal degeneration. Increased FGF-2 expression was accomplished by gene transfer to the retina via injection into the subretinal space of a recombinant adeno-associated virus (rAAV), containing the FGF-2 gene. Rescue effects were assessed by morphometry and electroretinographic analysis.

Journal

Documenta OphthalmologicaSpringer Journals

Published: Oct 6, 2004

References

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