Access the full text.
Sign up today, get DeepDyve free for 14 days.
M. Lavail, D. Yasumura, M. Matthes, Cathy Lau‐Villacorta, K. Unoki, C. Sung, R. Steinberg (1998)
Protection of mouse photoreceptors by survival factors in retinal degenerations.Investigative ophthalmology & visual science, 39 3
L. Sanftner, Katherine Rendahl, Dulce Quiroz, M. Coyne, Martha Ladner, William Manning, John Flannery (2001)
Recombinant AAV-mediated delivery of a tet-inducible reporter gene to the rat retina.Molecular therapy : the journal of the American Society of Gene Therapy, 3 5 Pt 1
P. Aebischer, M. Schluep, N. Déglon, J. Joseph, L. Hirt, B. Heyd, M. Goddard, J. Hammang, A. Zurn, A. Kato, F. Regli, E. Baetge (1996)
Intrathecal delivery of CNTF using encapsulated genetically modifiedxenogeneic cells in amyotrophic lateral sclerosis patientsNature Medicine, 2
C. Akpalaba, A. Oraedu, E. Nwanze (1986)
Biochemical studies on the effects of continuous light on the albino rat retina.Experimental eye research, 42 1
R. Mandel, S. Spratt, R. Snyder, S. Leff (1997)
Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats.Proceedings of the National Academy of Sciences of the United States of America, 94 25
Changdong Liu, Min Peng, A. Laties, Rong Wen (1998)
Preconditioning with Bright Light Evokes a Protective Response against Light Damage in the Rat RetinaThe Journal of Neuroscience, 18
Kazuhiko Unoki, M. Lavail (1994)
Protection of the rat retina from ischemic injury by brain-derived neurotrophic factor, ciliary neurotrophic factor, and basic fibroblast growth factor.Investigative ophthalmology & visual science, 35 3
E. Faktorovich, R. Steinberg, D. Yasumura, M. Matthes, M. Lavail (1992)
Basic fibroblast growth factor and local injury protect photoreceptors from light damage in the rat, 12
K. Masuda, I. Watanabe, K. Unoki, N. Ohba, T. Muramatsu (1995)
Functional Rescue of photoreceptors from the damaging effects of constant light by survival-promoting factors in the rat.Investigative ophthalmology & visual science, 36 10
A. Bilang‐Bleuel, Frédéric Revah, Phillippe Colin, Isabelle Locquet, J. Robert, J. Mallet, P. Horellou (1997)
Intrastriatal injection of an adenoviral vector expressing glial-cell-line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson disease.Proceedings of the National Academy of Sciences of the United States of America, 94 16
R. Wiegand, N. Giusto, L. Rapp, R. Anderson (1983)
Evidence for rod outer segment lipid peroxidation following constant illumination of the rat retina.Investigative ophthalmology & visual science, 24 10
I. Ranchon, J. Gorrand, J. Cluzel, M. Droy-lefaix, M. Doly (1999)
Functional protection of photoreceptors from light-induced damage by dimethylthiourea and Ginkgo biloba extract.Investigative ophthalmology & visual science, 40 6
L. Sanftner, Hilla Abel, W. Hauswirth, J. Flannery (2001)
Glial cell line derived neurotrophic factor delays photoreceptor degeneration in a transgenic rat model of retinitis pigmentosa.Molecular therapy : the journal of the American Society of Gene Therapy, 4 6
M. Lavail, G. Gorrin, M. Repaci, L. Thomas, H. Ginsberg (1987)
Genetic regulation of light damage to photoreceptors.Investigative ophthalmology & visual science, 28 7
M. Lavail, K. Unoki, D. Yasumura, M. Matthes, G. Yancopoulos, R. Steinberg (1992)
Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light.Proceedings of the National Academy of Sciences of the United States of America, 89 23
W. Noell, Virgil Walker, B. Kang, Steven Berman (1966)
Retinal damage by light in rats.Investigative ophthalmology, 5 5
J. Flannery, S. Zolotukhin, M. Vaquero, M. Lavail, N. Muzyczka, W. Hauswirth (1997)
Efficient photoreceptor-targeted gene expression in vivo by recombinant adeno-associated virus.Proceedings of the National Academy of Sciences of the United States of America, 94 13
A. Bachoud-Lévi, N. Déglon, J. Nguyen, J. Bloch, C. Bourdet, L. Winkel, P. Remy, M. Goddard, J. Lefaucheur, P. Brugières, S. Baudic, P. Césaro, M. Peschanski, P. Aebischer (2000)
Neuroprotective gene therapy for Huntington's disease using a polymer encapsulated BHK cell line engineered to secrete human CNTF.Human gene therapy, 11 12
Dana Lau, Laura Mcgee, Shangzhen Zhou, Katherine Rendahl, William Manning, Jaime Escobedo, John Flannery (2000)
Retinal degeneration is slowed in transgenic rats by AAV-mediated delivery of FGF-2.Investigative ophthalmology & visual science, 41 11
J. Lisman, G. Fain (1995)
Support for the equivalent light hypothesis for RPNature Medicine, 1
These experiments evaluate overexpression of basic fibroblast growth factor (FGF-2) as a treatment to decrease photoreceptor cell death in the constant light damage model of retinal degeneration. Increased FGF-2 expression was accomplished by gene transfer to the retina via injection into the subretinal space of a recombinant adeno-associated virus (rAAV), containing the FGF-2 gene. Rescue effects were assessed by morphometry and electroretinographic analysis.
Documenta Ophthalmologica – Springer Journals
Published: Oct 6, 2004
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.