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U Fuhr (1990)
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Eur J Clin Pharmacol (1992) 42:463-464 European Journal of e @Q erle@ g (~[~[~(~(~ @ Springer-Verlag 1992 Letter to the editors U. Fuhr 1, B. G. Woodcock 1, and M. Siewert 2 Department of Clinical Pharmacology, University Hospital, Frankfurt/M. and Central Laboratory of German Pharmacists,Eschborn, FRG Received: June 5,1991/Accepted in revised form: September 9, 1991 Key words: Verapamil, Cytochrome P450; theophylline, CYP1A2, drug interaction A decrease in the clearance of theophylline when verapamil is co-administered [1] is a clinically relevant drug interaction involving hepatic cytochrome P450 isoforms [2]. Evidence obtained from mammalian cells genetically engineered to express a single cytochrome P450 isoform has shown that CYPIA2 is responsible for a major part of theophylline metabolism in man [Fuhr et al. unpublished observation]. Investigations have now been done in vitro to establish whether verapamil is an inhibitor of and a substrate for CYPIA2. was found, but only 4 data points were available for analysis. The 35% inhibition of caffeine 3-demethylation by verapamil clearly indicates that verapamil binds to CYP1A2, since no other isoenzyme is expected to contribute significantly to the 3-demethylation of caffeine under t- 100- o o_ c~ 80- ¢. 60- 40- Verapamil as an inhibitor of CYP1A2
European Journal of Clinical Pharmacology – Springer Journals
Published: Apr 1, 1992
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