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Variation in oro-facial tardive dyskinesia during depot antipsychotic drug treatment

Variation in oro-facial tardive dyskinesia during depot antipsychotic drug treatment 213 81 81 4 4 Thomas R. E. Barnes David H. Wiles Department of Psychiatry St George's Hospital Medical School, Cranmer Terrace SW17 ORE London UK Crichton Royal Hospital Dumfries Scotland, UK Abstract Oro-facial (tardive) dyskinesia, occurring in patients on long-term antipsychotic (dopamine antagonist) medication, can be suppressed temperarily by increasing the drug dose. Lowering the dose can exacerbate the condition. In patients receiving regular fluphenazine decanoate (FPZ) and flupenthixol decanoate (FPT) injections, characteristic profiles of the fluctuations in plasma level concentrations, occurring during the injection interval, have been demonstrated. The possible effects of these relatively predictable plasma level changes on the severity of oro-facial dyskinesia, and parkinsonism, were investigated. Regular assessment of oro-facial dyskinesia throughout the injection interval was carried out in six patients receiving FPZ and two patients receiving FPT. In both groups, changes were observed in the severity of oro-facial dyskinesia consistent with the expected effects of drug level fluctuations. The main implication of this finding is that, in investigations of tardive dyskinesia in patients receiving depot medication, ratings should be carried out at a standard time relative to injections. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Variation in oro-facial tardive dyskinesia during depot antipsychotic drug treatment

Psychopharmacology , Volume 81 (4) – Nov 1, 1983

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References (16)

Publisher
Springer Journals
Copyright
Copyright © 1983 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF00427579
Publisher site
See Article on Publisher Site

Abstract

213 81 81 4 4 Thomas R. E. Barnes David H. Wiles Department of Psychiatry St George's Hospital Medical School, Cranmer Terrace SW17 ORE London UK Crichton Royal Hospital Dumfries Scotland, UK Abstract Oro-facial (tardive) dyskinesia, occurring in patients on long-term antipsychotic (dopamine antagonist) medication, can be suppressed temperarily by increasing the drug dose. Lowering the dose can exacerbate the condition. In patients receiving regular fluphenazine decanoate (FPZ) and flupenthixol decanoate (FPT) injections, characteristic profiles of the fluctuations in plasma level concentrations, occurring during the injection interval, have been demonstrated. The possible effects of these relatively predictable plasma level changes on the severity of oro-facial dyskinesia, and parkinsonism, were investigated. Regular assessment of oro-facial dyskinesia throughout the injection interval was carried out in six patients receiving FPZ and two patients receiving FPT. In both groups, changes were observed in the severity of oro-facial dyskinesia consistent with the expected effects of drug level fluctuations. The main implication of this finding is that, in investigations of tardive dyskinesia in patients receiving depot medication, ratings should be carried out at a standard time relative to injections.

Journal

PsychopharmacologySpringer Journals

Published: Nov 1, 1983

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