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L. Kikwai, N. Kanikkannan, R. Babu, Mandip Singh (2002)
Effect of vehicles on the transdermal delivery of melatonin across porcine skin in vitro.Journal of controlled release : official journal of the Controlled Release Society, 83 2
D. Jm (1993)
The relevance to humans of animal models for inhalation studies of cancer in the nose and upper airways., 2
L. Illum (2000)
Transport of drugs from the nasal cavity to the central nervous system.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 11 1
T. Sakane, S. Yamashita, T. Nadai, H. Sezaki (1997)
Direct drug transport from the nasal cavity to the cerebrospinal fluid. A new strategy for drug delivery to the brainStp Pharma Sciences, 7
Anand Tc, David Gf, B. Umberkoman, Saini Kd (1974)
Uptake of radioactivity by body fluids and tissues in rhesus monkeys after intravenous injection or intranasal spray of tritium-labelled oestradiol and progesterone.Current Science, 43
H. Tjälve, J. Henriksson (1999)
Uptake of metals in the brain via olfactory pathways.Neurotoxicology, 20 2-3
M. Berg, J. Verhoef, S. Romeijn, F. Merkus (2002)
Uptake of hydrocortisone into the cerebrospinal fluid of rats: comparison of intranasal and intravenous administration in the same animalStp Pharma Sciences, 12
J. Martinez, R. Duma, E. Nelson, F. Moretta (1973)
Experimental naegleria meningoencephalitis in mice. Penetration of the olfactory mucosal epithelium by Naegleria and pathologic changes produced: a light and electron microscope study.Laboratory investigation; a journal of technical methods and pathology, 29 2
T. Seki, N. Sato, T. Hasegawa, T. Kawaguchi, K. Juni (1994)
Nasal absorption of zidovudine and its transport to cerebrospinal fluid in rats.Biological & pharmaceutical bulletin, 17 8
Mascha berg, P. Merkus, S. Romeijn, J. Verhoef, F. Merkus (2003)
Hydroxocobalamin Uptake into the Cerebrospinal Fluid after Nasal and Intravenous Delivery in Rats and HumansJournal of Drug Targeting, 11
(1995)
Knocking on the cerebral door
Kirby Jarolim, J. McCosh, M. Howard, D. John (2000)
A LIGHT MICROSCOPY STUDY OF THE MIGRATION OF NAEGLERIA FOWLERI FROM THE NASAL SUBMUCOSA TO THE CENTRAL NERVOUS SYSTEM DURING THE EARLY STAGE OF PRIMARY AMEBIC MENINGOENCEPHALITIS IN MICE, 86
R. Pietrowsky, L. Claassen, Hauke Frercks, H. Fehm, J. Born (2001)
Time Course of Intranasally Administered Cholecystokinin-8 on Central Nervous EffectsNeuropsychobiology, 43
(1998)
Fact or fiction? J
F. Qadri, E. Badoer, T. Stadler, T. Unger (1991)
Angiotensin II-induced noradrenaline release from anterior hypothalamus in conscious rats: a brain microdialysis studyBrain Research, 563
I. Derad, Karen Willeke, R. Pietrowsky, J. Born, Horst Fehm (1998)
Intranasal angiotensin II directly influences central nervous regulation of blood pressure.American journal of hypertension, 11 8 Pt 1
(2000)
novel approaches for transporting therapeutics
(1991)
a brain microdialysis study
M. Dahlin, E. Björk (2000)
Nasal absorption of (S)-UH-301 and its transport into the cerebrospinal fluid of rats.International journal of pharmaceutics, 195 1-2
R. Pietrowsky, Andrea Thiemann, W. Kern, H. Fehm, J. Born (1996)
A nose-brain pathway for psychotropic peptides: evidence from a brain evoked potential study with cholecystokininPsychoneuroendocrinology, 21
J. DeSesso (1993)
The relevance to humans of animal models for inhalation studies of cancer in the nose and upper airways.Quality assurance, 2 3
T. Yajima, K. Juni, M. Saneyoshi, T. Hasegawa, T. Kawaguchi (1998)
Direct transport of 2',3'-didehydro-3'-deoxythymidine (D4T) and its ester derivatives to the cerebrospinal fluid via the nasal mucous membrane in rats.Biological & pharmaceutical bulletin, 21 3
(1999)
Nasal melatonin compositions
A. Veltmar, J. Culman, F. Qadri, W. Rascher, T. Unger (1992)
Involvement of adrenergic and angiotensinergic receptors in the paraventricular nucleus in the angiotensin II-induced vasopressin release.The Journal of pharmacology and experimental therapeutics, 263 3
S. Gizurarson, E. Bechgaard (1991)
Intranasal administration of insulin to humans.Diabetes research and clinical practice, 12 2
(1973)
a light and electron microscope study
K. Chou, M. Donovan (1997)
Distribution of antihistamines into the CSF following intranasal delivery.Biopharmaceutics & drug disposition, 18 4
T. Sakane, Motohiro Akizuki, Masako Yoshida, S. Yamashita, T. Nadai, M. Hashida, H. Sezaki (1991)
Transport of cephalexin to the cerebrospinal fluid directly from the nasal cavityJournal of Pharmacy and Pharmacology, 43
Javier Torao, P. Rijn-Bikker, Paull Merkus, H. Guchelaar (2000)
Quantitative determination of melatonin in human plasma and cerebrospinal fluid with high-performance liquid chromatography and fluorescence detection.Biomedical chromatography : BMC, 14 5
R. Smolnik, M. Mölle, H. Fehm, J. Born (1999)
Brain Potentials and Attention after Acute and Subchronic Intranasal Administration of ACTH 4–10 and Desacetyl-α-MSH in HumansNeuroendocrinology, 70
M. Berg, S. Romeijn, J. Verhoef, F. Merkus (2002)
Serial cerebrospinal fluid sampling in a rat model to study drug uptake from the nasal cavityJournal of Neuroscience Methods, 116
Xin-feng Liu, John Fawcett, R. Thorne, T. Defor, William II (2001)
Intranasal administration of insulin-like growth factor-I bypasses the blood–brain barrier and protects against focal cerebral ischemic damageJournal of the Neurological Sciences, 187
J. Temsamani, J. Scherrmann, Anthony Rees, Michel Kaczorek (2000)
Brain drug delivery technologies: novel approaches for transporting therapeutics.Pharmaceutical science & technology today, 3 5
M. Hussain, Dariel Rakestraw, S. Rowe, B. Aungst (1990)
Nasal administration of a cognition enhancer provides improved bioavailability but not enhanced brain delivery.Journal of pharmaceutical sciences, 79 9
S. Mathison, R. Nagilla, U. Kompella (1998)
Nasal route for direct delivery of solutes to the central nervous system: fact or fiction?Journal of drug targeting, 5 6
R. Pietrowsky, C. Strüben, M. Mölle, H. Fehm, J. Born (1996)
Brain potential changes after intranasal vs. intravenous administration of vasopressin: evidence for a direct nose-brain pathway for peptide effects in humansBiological Psychiatry, 39
(1999)
Smolnik , M . Molle , H . L . Fehm , and J . Born . Brain potentials and attention after acute and subchronic intranasal administration of ACTH 4 - 10 and desacetyl - alpha - MSH in humans
P. Merkus, H. Guchelaar, D. Bosch, F. Merkus (2003)
Direct access of drugs to the human brain after intranasal drug administration?Neurology, 60
(1998)
. Willeke , R . Pietrowsky , J . Born , and H . L . Fehm . Intranasal angiotensin II directly influences central nervous regulation of blood pressure
M. Dahlin, B. Jansson, E. Björk (2001)
Levels of dopamine in blood and brain following nasal administration to rats.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 14 1
W. Kern, J. Born, Herbert Schreiber, Horst Fehm (1999)
Central nervous system effects of intranasally administered insulin during euglycemia in men.Diabetes, 48 3
Purpose. To investigate the possibility of direct transport of melatonin from the nasal cavity into the cerebrospinal fluid (CSF) after nasal administration in rats and to compare the animal results with a human study.
Pharmaceutical Research – Springer Journals
Published: Oct 1, 2004
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