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Unraveling the complexities of cannabinoid receptor 2 (CB2) immune regulation in health and disease

Unraveling the complexities of cannabinoid receptor 2 (CB2) immune regulation in health and disease It has become clear that the endocannabinoid system is a potent regulator of immune responses, with the cannabinoid receptor 2 (CB2) as the key component due to its high expression by all immune subtypes. CB2 has been shown to regulate immunity by a number of mechanisms including development, migration, proliferation, and effector functions. In addition, CB2 has been shown to modulate the function of all immune cell types examined to date. CB2 is a Gi-protein-coupled receptor and thus exhibits a complex pharmacology allowing both stimulatory and inhibitory signaling that depends on receptor expression levels, ligand concentration, and cell lineage specificities. Here, we discuss both in vitro and in vivo experimental evidence that CB2 is a potent regulator of immune responses making it a prime target for the treatment of inflammatory diseases. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Immunologic Research Springer Journals

Unraveling the complexities of cannabinoid receptor 2 (CB2) immune regulation in health and disease

Immunologic Research , Volume 51 (1) – May 29, 2011

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References (92)

Publisher
Springer Journals
Copyright
Copyright © 2011 by Springer Science+Business Media, LLC
Subject
Medicine & Public Health; Internal Medicine; Immunology; Medicine/Public Health, general; Allergology
ISSN
0257-277X
eISSN
1559-0755
DOI
10.1007/s12026-011-8210-5
pmid
21626285
Publisher site
See Article on Publisher Site

Abstract

It has become clear that the endocannabinoid system is a potent regulator of immune responses, with the cannabinoid receptor 2 (CB2) as the key component due to its high expression by all immune subtypes. CB2 has been shown to regulate immunity by a number of mechanisms including development, migration, proliferation, and effector functions. In addition, CB2 has been shown to modulate the function of all immune cell types examined to date. CB2 is a Gi-protein-coupled receptor and thus exhibits a complex pharmacology allowing both stimulatory and inhibitory signaling that depends on receptor expression levels, ligand concentration, and cell lineage specificities. Here, we discuss both in vitro and in vivo experimental evidence that CB2 is a potent regulator of immune responses making it a prime target for the treatment of inflammatory diseases.

Journal

Immunologic ResearchSpringer Journals

Published: May 29, 2011

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