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Uni- and multivariate models for investigating potential prognostic factors in idiopathic sudden sensorineural hearing loss

Uni- and multivariate models for investigating potential prognostic factors in idiopathic sudden... With a worldwide incidence estimated at 8–15 per 100,000 population a year, idiopathic sudden sensorineural hearing loss (ISSHL) is a common clinical finding for otologists. There is a shortage of information on the clinical factors capable of predicting hearing recovery and response to therapy. The aim of the present study was to retrospectively investigate the prognostic value of clinical variables in relation to hearing recovery, in a cohort of 117 consecutive patients with ISSHL. Clinical parameters (signs, symptoms, comorbidities and treatments) and audiometric data were analyzed with univariate and multivariate statistical approaches for prognostic purposes to identify any correlation with hearing recovery, also expressed according to the Wilson criteria. Univariate analysis showed that age and hypertension were significantly related to hearing outcome ( p = 0.004 and p = 0.015, respectively). Elderly patients and those with hypertension were at higher risk of experiencing no hearing recovery (OR = 3.25 and OR = 2.89, respectively). Age was an independent prognostic factor on multivariate analysis ( p = 0.007). Tinnitus as a presenting symptom showed a trend towards an association with hearing recovery ( p = 0.07). The treatment regimen, the time elapsing between the onset of symptoms and the start of therapy ( p = 0.34), and the duration of the treatment ( p = 0.83) were unrelated to recovery on univariate analysis. Among the parameters considered, only age was significantly and independently related to hearing outcome. There is a need for well-designed, randomized clinical trials to enable an evidence-based protocol to be developed for the treatment of ISSHL. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Archives of Oto-Rhino-Laryngology Springer Journals

Uni- and multivariate models for investigating potential prognostic factors in idiopathic sudden sensorineural hearing loss

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References (36)

Publisher
Springer Journals
Copyright
Copyright © 2015 by Springer-Verlag Berlin Heidelberg
Subject
Medicine & Public Health; Otorhinolaryngology; Neurosurgery; Head and Neck Surgery
ISSN
0937-4477
eISSN
1434-4726
DOI
10.1007/s00405-014-2992-8
pmid
24664295
Publisher site
See Article on Publisher Site

Abstract

With a worldwide incidence estimated at 8–15 per 100,000 population a year, idiopathic sudden sensorineural hearing loss (ISSHL) is a common clinical finding for otologists. There is a shortage of information on the clinical factors capable of predicting hearing recovery and response to therapy. The aim of the present study was to retrospectively investigate the prognostic value of clinical variables in relation to hearing recovery, in a cohort of 117 consecutive patients with ISSHL. Clinical parameters (signs, symptoms, comorbidities and treatments) and audiometric data were analyzed with univariate and multivariate statistical approaches for prognostic purposes to identify any correlation with hearing recovery, also expressed according to the Wilson criteria. Univariate analysis showed that age and hypertension were significantly related to hearing outcome ( p = 0.004 and p = 0.015, respectively). Elderly patients and those with hypertension were at higher risk of experiencing no hearing recovery (OR = 3.25 and OR = 2.89, respectively). Age was an independent prognostic factor on multivariate analysis ( p = 0.007). Tinnitus as a presenting symptom showed a trend towards an association with hearing recovery ( p = 0.07). The treatment regimen, the time elapsing between the onset of symptoms and the start of therapy ( p = 0.34), and the duration of the treatment ( p = 0.83) were unrelated to recovery on univariate analysis. Among the parameters considered, only age was significantly and independently related to hearing outcome. There is a need for well-designed, randomized clinical trials to enable an evidence-based protocol to be developed for the treatment of ISSHL.

Journal

European Archives of Oto-Rhino-Laryngology – Springer Journals

Published: Aug 1, 2015

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