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Unaltered 5-HT- and desipramine-sensitive ( 3 H)imipramine binding and ( 3 H)5-HT uptake in rat brain after chronic imipramine and norzimeldine treatment

Unaltered 5-HT- and desipramine-sensitive ( 3 H)imipramine binding and ( 3 H)5-HT uptake in rat... 213 94 94 2 2 Jan Marcusson Inger T. Bäckström Svante B. Ross Department of Geriatric Medicine University of Ume» S901 87 Ume» Sweden Department of Pathology University of Ume» S-901 87 Ume» Sweden Department of Pharmacology Research and Developmental Laboratories Astra Alab AB S-151 85 Södertälje Sweden Abstract Several reports have shown heterogeneity of ( 3 H)imipramine binding to brain membranes. Recently, a high affinity and 5-HT sensitive ( 3 H)imipramine binding site of protein nature, that was suggested to be identical to the substrate recognition site for 5-HT uptake, was demonstrated. Since most studies on the regulation of the ( 3 H)imipramine binding sites by antidepressants have used desipramine displaceable binding, which is heterogenous in nature and contains binding not related to 5-HT uptake sites, the present report studies the possible effects of chronic (3 weeks) administration of imipramine or norzimeldine (10 mg/kg intraperitoneally twice daily) on 5-HT sensitive ( 3 H)imipramine binding sites. For comparison, desipramine sensitive binding was also studied, as well as the physiological correlate 5-HT uptake. There were no changes in either ( 3 H)imipramine binding or 5-HT uptake after the antidepressant treatment. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Unaltered 5-HT- and desipramine-sensitive ( 3 H)imipramine binding and ( 3 H)5-HT uptake in rat brain after chronic imipramine and norzimeldine treatment

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References (14)

Publisher
Springer Journals
Copyright
Copyright © 1988 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF00176844
Publisher site
See Article on Publisher Site

Abstract

213 94 94 2 2 Jan Marcusson Inger T. Bäckström Svante B. Ross Department of Geriatric Medicine University of Ume» S901 87 Ume» Sweden Department of Pathology University of Ume» S-901 87 Ume» Sweden Department of Pharmacology Research and Developmental Laboratories Astra Alab AB S-151 85 Södertälje Sweden Abstract Several reports have shown heterogeneity of ( 3 H)imipramine binding to brain membranes. Recently, a high affinity and 5-HT sensitive ( 3 H)imipramine binding site of protein nature, that was suggested to be identical to the substrate recognition site for 5-HT uptake, was demonstrated. Since most studies on the regulation of the ( 3 H)imipramine binding sites by antidepressants have used desipramine displaceable binding, which is heterogenous in nature and contains binding not related to 5-HT uptake sites, the present report studies the possible effects of chronic (3 weeks) administration of imipramine or norzimeldine (10 mg/kg intraperitoneally twice daily) on 5-HT sensitive ( 3 H)imipramine binding sites. For comparison, desipramine sensitive binding was also studied, as well as the physiological correlate 5-HT uptake. There were no changes in either ( 3 H)imipramine binding or 5-HT uptake after the antidepressant treatment.

Journal

PsychopharmacologySpringer Journals

Published: Feb 1, 1988

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