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ISSN 0003-6838, Applied Biochemistry and Microbiology, 2019, Vol. 55, No. 6, pp. 571–581. © Pleiades Publishing, Inc., 2019. Russian Text © The Author(s), 2019, published in Prikladnaya Biokhimiya i Mikrobiologiya, 2019, Vol. 55, No. 6, pp. 523–534. a a a, M. V. Zamakhaev , A. V. Goncharenko , and M. S. Shumkov * Bach Institute of Biochemistry, Fundamentals of Biotechnology Federal Research Center, Russian Academy of Sciences, Moscow, 119071 Russia *e-mail: shumkovm@gmail.com Received December 24, 2018; revised March 18, 2019; accepted June 20, 2019 Abstract—Persistence is a phenomenon in which bacteria avoid the lethal effects of antibiotics due to their transition to a physiological state, which enables tolerance to antibacterial drugs. Among the factors that con- tribute to persistence, a special role belongs to toxin–antitoxin (TA) systems, which are involved in the regu- lation of a wide range of physiological processes and have a significant effect on the results of antibiotic ther- apy. This review examines the mechanisms of the participation of TA systems in the formation of persistent bacteria, as well as the clinical importance of the phenomenon of persistence and methods for the control of phenotypically tolerant cells via regulation of the activity level of TA modules.
Applied Biochemistry and Microbiology – Springer Journals
Published: Dec 6, 2019
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