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Tolerance in the depression of intake when amphetamine is added to the rat's food

Tolerance in the depression of intake when amphetamine is added to the rat's food 213 29 29 1 1 Jaak Panksepp D. A. Booth Department of Psychology Bowling Green State University 43403 Bowling Green Ohio Laboratory of Experimental Psychology University of Sussex Brighton England Abstract The depression of intake initially seen when a rat is placed on an amphetamine adulterated diet disappears over a week at the dose level of 0.2 mg amphetamine per gram of chow. The decreased effectiveness of amphetamine is attributable primarily to accruing deprivation rather than to either behavioral or pharmacological tolerance. Ventromedial hypothalamic lesions attenuate the tolerance, whereas lateral hypothalamic lesions decrease the basic anorexigenic effect of amphetamine. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Tolerance in the depression of intake when amphetamine is added to the rat's food

Psychopharmacology , Volume 29 (1) – Mar 1, 1973

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References (15)

Publisher
Springer Journals
Copyright
Copyright © 1973 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF00421210
Publisher site
See Article on Publisher Site

Abstract

213 29 29 1 1 Jaak Panksepp D. A. Booth Department of Psychology Bowling Green State University 43403 Bowling Green Ohio Laboratory of Experimental Psychology University of Sussex Brighton England Abstract The depression of intake initially seen when a rat is placed on an amphetamine adulterated diet disappears over a week at the dose level of 0.2 mg amphetamine per gram of chow. The decreased effectiveness of amphetamine is attributable primarily to accruing deprivation rather than to either behavioral or pharmacological tolerance. Ventromedial hypothalamic lesions attenuate the tolerance, whereas lateral hypothalamic lesions decrease the basic anorexigenic effect of amphetamine.

Journal

PsychopharmacologySpringer Journals

Published: Mar 1, 1973

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