Rationale Recent studies have demonstrated that mTORC1 ylation levels of mTORC1, 4E-BP-1, p70S6K, Akt, and ERK activation may be related to antidepressant action. However, in rat primary hippocampal neurons. Changes in BDNF, den- the relationship between mTORC1 signaling activation and dritic outgrowth, spine density, and synaptic proteins (PSD- currently prescribed antidepressants remains unclear. 95, synaptophysin, and GluR1) were measured. Objective The aim of the present study was to determine Results Tianeptine significantly increased the phosphorylation whether alterations in mTORC1 signaling are observable fol- of mTORC1, 4E-BP-1, p70S6K, Akt, and ERK. The increase lowing treatment with tianeptine under toxic conditions in- in mTOR phosphorylation was blocked by the PI3K, MEK, duced by B27 deprivation. Additionally, we investigated and mTORC1 inhibitors. Tianeptine increased BDNF, dendrit- whether this drug affects synaptic proteins, neurite outgrowth, ic outgrowth, spine density, and synaptic proteins; all of these and spine density via mTORC1 signaling. effects were blocked by the mTORC1 inhibitor. Conclusions In this study, we demonstrated that tianeptine activates the mTORC1 signaling pathway and increases den- Electronic supplementary material The online version of this article dritic outgrowth, spine density, and synaptic proteins through (doi:10.1007/s00213-016-4309-7) contains supplementary material, mTORC1 signaling under toxic conditions in rat primary
Psychopharmacology – Springer Journals
Published: Apr 30, 2016
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera