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Tianeptine induces mTORC1 activation in rat hippocampal neurons under toxic conditions

Tianeptine induces mTORC1 activation in rat hippocampal neurons under toxic conditions Rationale Recent studies have demonstrated that mTORC1 ylation levels of mTORC1, 4E-BP-1, p70S6K, Akt, and ERK activation may be related to antidepressant action. However, in rat primary hippocampal neurons. Changes in BDNF, den- the relationship between mTORC1 signaling activation and dritic outgrowth, spine density, and synaptic proteins (PSD- currently prescribed antidepressants remains unclear. 95, synaptophysin, and GluR1) were measured. Objective The aim of the present study was to determine Results Tianeptine significantly increased the phosphorylation whether alterations in mTORC1 signaling are observable fol- of mTORC1, 4E-BP-1, p70S6K, Akt, and ERK. The increase lowing treatment with tianeptine under toxic conditions in- in mTOR phosphorylation was blocked by the PI3K, MEK, duced by B27 deprivation. Additionally, we investigated and mTORC1 inhibitors. Tianeptine increased BDNF, dendrit- whether this drug affects synaptic proteins, neurite outgrowth, ic outgrowth, spine density, and synaptic proteins; all of these and spine density via mTORC1 signaling. effects were blocked by the mTORC1 inhibitor. Conclusions In this study, we demonstrated that tianeptine activates the mTORC1 signaling pathway and increases den- Electronic supplementary material The online version of this article dritic outgrowth, spine density, and synaptic proteins through (doi:10.1007/s00213-016-4309-7) contains supplementary material, mTORC1 signaling under toxic conditions in rat primary http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Tianeptine induces mTORC1 activation in rat hippocampal neurons under toxic conditions

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Publisher
Springer Journals
Copyright
Copyright © 2016 by Springer-Verlag Berlin Heidelberg
Subject
Biomedicine; Neurosciences; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/s00213-016-4309-7
pmid
27129862
Publisher site
See Article on Publisher Site

Abstract

Rationale Recent studies have demonstrated that mTORC1 ylation levels of mTORC1, 4E-BP-1, p70S6K, Akt, and ERK activation may be related to antidepressant action. However, in rat primary hippocampal neurons. Changes in BDNF, den- the relationship between mTORC1 signaling activation and dritic outgrowth, spine density, and synaptic proteins (PSD- currently prescribed antidepressants remains unclear. 95, synaptophysin, and GluR1) were measured. Objective The aim of the present study was to determine Results Tianeptine significantly increased the phosphorylation whether alterations in mTORC1 signaling are observable fol- of mTORC1, 4E-BP-1, p70S6K, Akt, and ERK. The increase lowing treatment with tianeptine under toxic conditions in- in mTOR phosphorylation was blocked by the PI3K, MEK, duced by B27 deprivation. Additionally, we investigated and mTORC1 inhibitors. Tianeptine increased BDNF, dendrit- whether this drug affects synaptic proteins, neurite outgrowth, ic outgrowth, spine density, and synaptic proteins; all of these and spine density via mTORC1 signaling. effects were blocked by the mTORC1 inhibitor. Conclusions In this study, we demonstrated that tianeptine activates the mTORC1 signaling pathway and increases den- Electronic supplementary material The online version of this article dritic outgrowth, spine density, and synaptic proteins through (doi:10.1007/s00213-016-4309-7) contains supplementary material, mTORC1 signaling under toxic conditions in rat primary

Journal

PsychopharmacologySpringer Journals

Published: Apr 30, 2016

References

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