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E. Jannini, S. Ulisse, M. D'armiento (1995)
Thyroid hormone and male gonadal function.Endocrine reviews, 16 4
R. Sciarrillo, M. Falco, F. Virgilio, V. Laforgia, A. Capaldo, F. Gay, S. Valiante, L. Varano (2008)
Morphological and Functional Changes in the Thyroid Gland of Methyl Thiophanate-Injected Lizards, Podarcis siculaArchives of Environmental Contamination and Toxicology, 55
R. Mann, J. Sánchez-Hernández, Elisabete Serra, A. Soares (2007)
Bioaccumulation of Cd by a European lacertid lizard after chronic exposure to Cd-contaminated food.Chemosphere, 68 8
W. Hopkins (2005)
Use of Tissue Residues in Reptile Ecotoxicology: A Call for Integration and Experimentalism
AGE Wilson, DC Thake, WE Heydens, DW Brewster, KJ Hotz (1996)
Mode of action of thyroid tumor formation in the male Long-Evans rat administered high doses of alachlorFundam Appl Toxicol, 33
C. Schmutzler, Inka Gotthardt, P. Hofmann, B. Radovic, G. Kovacs, Luise Stemmler, Inga Nobis, A. Bacinski, B. Mentrup, P. Ambrugger, A. Grüters, L. Malendowicz, Julie Christoffel, H. Jarry, D. Seidlová‐Wuttke, W. Wuttke, J. Köhrle (2007)
Endocrine Disruptors and the Thyroid Gland—A Combined in Vitro and in Vivo Analysis of Potential New BiomarkersEnvironmental Health Perspectives, 115
A. Cardone, Raffaella Comitato, F. Angelini (2008)
Spermatogenesis, epididymis morphology and plasma sex steroid secretion in the male lizard Podarcis sicula exposed to diuron.Environmental research, 108 2
B. Gupta, J. Thapliyal (1985)
Role of thyroid and testicular hormones in the oxidative metabolism of the Indian garden lizard, Calotes versicolor.General and comparative endocrinology, 58 1
J. Cook, L. Mullin, S. Frame, L. Biegel (1993)
Investigation of a mechanism for Leydig cell tumorigenesis by linuron in rats.Toxicology and applied pharmacology, 119 2
P. Matthiessen, I. Johnson (2007)
Implications of research on endocrine disruption for the environmental risk assessment, regulation and monitoring of chemicals in the European Union.Environmental pollution, 146 1
E. Jannini, S. Dolci, S. Ulisse, V. Nikodem (1994)
Developmental regulation of the thyroid hormone receptor alpha 1 mRNA expression in the rat testis.Molecular endocrinology, 8 1
J. Thapliyal, S. Gupta, R. Garg (1974)
Effects of thyroidectomy on the chequered water-snake, Natrix piscator.The Journal of endocrinology, 60 3
M. Amaral, Rita Bicho, M. Carretero, J. Sánchez-Hernández, A. Faustino, A. Soares, R. Mann (2012)
The use of a lacertid lizard as a model for reptile ecotoxicology studies: part 2--biomarkers of exposure and toxicity among pesticide exposed lizards.Chemosphere, 87 7
D. Sparling, G. Linder, C. Bishop, S. Krest (2010)
Recent Advancements in Amphibian and Reptile Ecotoxicology
M. Carretero, R. Ribeiro, D. Barbosa, P. Sá-Sousa, D. Harris (2006)
Spermatogenesis in two Iberian Podarcis lizards: relationships with male traitsAnimal Biology, 56
M. Amaral, M. Carretero, Rita Bicho, A. Soares, R. Mann (2012)
The use of a lacertid lizard as a model for reptile ecotoxicology studies--part 1 field demographics and morphology.Chemosphere, 87 7
D. Holsberger, P. Cooke (2005)
Understanding the role of thyroid hormone in Sertoli cell development: a mechanistic hypothesisCell and Tissue Research, 322
N. Stacey, Duncan MacKenzie, Tracy Marchant, L. Kyle, Richard Peter (1984)
Endocrine changes during natural spawning in the white sucker, Catostomus commersoni. I. Gonadotropin, growth hormone, and thyroid hormones.General and comparative endocrinology, 56 3
M. Wagner, S. Wajner, A. Maia (2008)
The role of thyroid hormone in testicular development and function.The Journal of endocrinology, 199 3
M. Boas, U. Feldt-Rasmussen, N. Skakkebaek, K. Main (2006)
Environmental chemicals and thyroid function.European journal of endocrinology, 154 5
J. Vandenbergh (2004)
Animal models and studies of in utero endocrine disruptor effects.ILAR journal, 45 4
Alan Wilson, D. Thake, W. Heydens, D. Brewster, K. Hotz (1996)
Mode of Action of Thyroid Tumor Formation in the Male Long–Evans Rat Administered High Doses of AlachlorToxicological Sciences, 33
En homenaje, Carolina Silvera-Simón, Julio Mena-Portales, J. Gené, J. Cano, J. Guarro (2009)
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS
G. Mosconi, I. Rosa, S. Bucci, L. Morosi, M. Franzoni, A. Polzonetti-Magni, R. Pascolini (2005)
Plasma sex steroid and thyroid hormones profile in male water frogs of the Rana esculenta complex from agricultural and pristine areas.General and comparative endocrinology, 142 3
C. Walker, M. Ronis (1989)
The monooxygenases of birds, reptiles and amphibians.Xenobiotica; the fate of foreign compounds in biological systems, 19 10
Maryann Plowman, W. Lynn (1973)
The role of the thyroid in testicular function in the gecko, Coleonyx variegatus.General and comparative endocrinology, 20 2
E. Diamanti-Kandarakis, J. Bourguignon, L. Giudice, R. Hauser, G. Prins, A. Soto, R. Zoeller, A. Gore (2009)
Endocrine-disrupting chemicals: an Endocrine Society scientific statement.Endocrine reviews, 30 4
C. Haldar-Misra, J. Thapliyal (1981)
Thyroid in reproduction of reptiles.General and comparative endocrinology, 43 4
J. Meeker, M. Boas (2011)
Pesticides and Thyroid Hormones
H. John-Alder (1990)
Thyroid regulation of resting metabolic rate and intermediary metabolic enzymes in a lizard (Sceloporus occidentalis).General and comparative endocrinology, 77 1
D. Crump, Kate Werry, N. Veldhoen, G. Aggelen, C. Helbing (2002)
Exposure to the herbicide acetochlor alters thyroid hormone-dependent gene expression and metamorphosis in Xenopus Laevis.Environmental Health Perspectives, 110
J. Nriagu (2011)
Encyclopedia of environmental health
Elizabeth Hewitt, D. Crain, M. Gunderson, L. Guillette (2002)
Thyroid status in juvenile alligators (Alligator mississippiensis) from contaminated and reference sites on Lake Okeechobee, Florida, USA.Chemosphere, 47 10
Craig McFarland, M. Quinn, Matthew Bazar, L. Talent, Mark Johnson (2009)
Toxic effects of oral hexahydro‐1,3,5‐trinitro‐1,3,5‐triazine in the western fence lizard (Sceloporus occidentalis)Environmental Toxicology and Chemistry, 28
J. Leatherland (2005)
Reflections on the thyroidology of fishes : from molecules to humankind, 2
T. Zhou, H. John-Alder, P. Weis, J. Weis (1999)
Thyroidal status of mummichogs (Fundulus heteroclitus) from a polluted versus a reference habitatEnvironmental Toxicology and Chemistry, 18
B. Pauli, S. Money, D. Sparling (2010)
Ecotoxicology of Pesticides in Reptiles
M. Jugan, Y. Lévi, J. Blondeau (2010)
Endocrine disruptors and thyroid hormone physiology.Biochemical pharmacology, 79 7
N. Veldhoen, C. Helbing (2001)
Detection of environmental endocrine‐disruptor effects on gene expression in live Rana catesbeiana tadpoles using a tail fin biopsy techniqueEnvironmental Toxicology and Chemistry, 20
T. Capriglione, S. Iorio, F. Gay, A. Capaldo, M. Vaccaro, M. Morescalchi, V. Laforgia (2011)
Genotoxic effects of the fungicide thiophanate-methyl on Podarcis sicula assessed by micronucleus test, comet assay and chromosome analysisEcotoxicology, 20
H. John-Alder (1984)
Reduced aerobic capacity and locomotory endurance in thyroid-deficient lizards.The Journal of experimental biology, 109
JP Thapliyal, SC Gupta, RK Garg (1974)
Effects of thyroidectomy on checkered water-snakeJ Endocrinol, 60
A. Cardone, F. Angelini, T. Esposito, Raffaella Comitato, B. Varriale (2000)
The expression of androgen receptor messenger RNA is regulated by tri-iodothyronine in lizard testisThe Journal of Steroid Biochemistry and Molecular Biology, 72
Jeremy Buzzard, J. Morrison, M. O’Bryan, Q. Song, N. Wreford (2000)
Developmental Expression of Thyroid Hormone Receptors in the Rat Testis1, 62
T. Manning (2005)
ENDOCRINE-DISRUPTING CHEMICALS: A REVIEW OF THE STATE OF THE SCIENCE
F. Virgilio, R. Sciarrillo, M. Falco, Raffaella Comitato, V. Laforgia, L. Varano, A. Cardone (2004)
Temporal expression of thyroid hormone receptor alpha1 in the liver of the lizard Podarcis sicula.Journal of experimental zoology. Part A, Comparative experimental biology, 301 3
P. Galán (1999)
Demography and population dynamics of the lacertid lizard Podarcis bocagei in north‐west SpainJournal of Zoology, 249
D. Crain, L. Guillette (1998)
Reptiles as models of contaminant-induced endocrine disruption.Animal reproduction science, 53 1-4
S. Andò, G. Ciarcia, M. Panno, E. Imbrogno, G. Tarantino, M. Buffone, E. Beraldi, F. Angelini, V. Botte (1992)
Sex steroids levels in the plasma and testis during the reproductive cycle of lizard Podarcis s. sicula Raf.General and comparative endocrinology, 85 1
P Galán (1995)
Ciclos de actividad de Podarcis bocagei en el noroeste ibéricoRev Española Herpetol, 9
D. Sparling, G. Linder, C. Bishop, S. Krest (2010)
Ecotoxicology of amphibians and reptiles
Jiliang Zhang, Zhenghong Zuo, Chengyong He, Di Wu, Yixin Chen, Chonggang Wang (2009)
Inhibition of thyroidal status related to depression of testicular development in Sebastiscus marmoratus exposed to tributyltin.Aquatic toxicology, 94 1
A. Cheek, C. Ide, J. Bollinger, C. Rider, John Mclachlan (1999)
Alteration of Leopard Frog (Rana pipiens) Metamorphosis by the Herbicide AcetochlorArchives of Environmental Contamination and Toxicology, 37
A. Scott, D. Mackenzie, N. Stacey (1984)
Endocrine changes during natural spawning in the white sucker, Catostomus commersoni. II. Steroid hormones.General and comparative endocrinology, 56 3
R. Mann, R. Hyne, Catherine Choung, S. Wilson (2009)
Amphibians and agricultural chemicals: review of the risks in a complex environment.Environmental pollution, 157 11
S. Gardner, E. Oberdorster (2005)
Toxicology of reptiles.
C. Helbing, K. Ovaska, L. Ji (2006)
Evaluation of the effect of acetochlor on thyroid hormone receptor gene expression in the brain and behavior of Rana catesbeiana tadpoles.Aquatic toxicology, 80 1
H. Lange, J. Lahr, J. Pol, Y. Wessels, J. Faber (2009)
Ecological vulnerability in wildlife: An expert judgment and multicriteria analysis tool using ecological traits to assess relative impact of pollutantsEnvironmental Toxicology and Chemistry, 28
R. Sciarrillo, V. Laforgia, A. Cavagnuolo, L. Varano, F. Virgilio (2000)
Annual variations of thyroid activity in the lizard Podarcis sicula (Squamata, Lacertidae)Italian Journal of Zoology, 67
Pesticide exposure has been related with thyroid disrupting effects in different vertebrate species. However, very little is known about the effects of these compounds in reptiles. In the Mediterranean area, lacertid lizards are the most abundant vertebrate group in agroecosystems, and have been identified as potential model species for reptile ecotoxicology. The aim of this study was to understand if the herbicides applied in corn fields have thyroid disruptive effects in the lizard Podarcis bocagei. Adult male lizards were captured in north-western Portugal in corn fields treated with herbicides (exposed sites), and in organic agricultural fields (reference sites). Thyroid and male gonad morphology and functionality, and testosterone levels were investigated through histological, immunohistochemical and biochemical techniques. Lizards from exposed locations displayed thyroid follicular lumens with more reabsorption vacuoles and significantly larger follicular area than those from reference fields. Furthermore, testes of lizards from exposed locations had significantly larger seminiferous tubule diameters, significantly higher number of spermatogenic layers and displayed an up-regulation of thyroid hormone receptors when compared with lizards from reference areas. These findings strongly suggest that the complex mixture of herbicides that lizards are exposed to in agricultural areas have thyroid disrupting effects which ultimately affect the male reproductive system. Alachlor, which has demonstrated thyroid effects in mammals, may be largely responsible for the observed effects.
Ecotoxicology – Springer Journals
Published: Nov 10, 2012
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