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Thickening of glomerular basement membrane in spontaneously diabetic rats

Thickening of glomerular basement membrane in spontaneously diabetic rats 125 15 15 4 4 S. Yagihashi Y. Goto M. Kakizaki N. Kaseda First Department of Pathology and Third Department of Internal Medicine Hirosaki University School of Medicine Hirosaki Japan Third Department of Internal Medicine Tohoku University School of Medicine Sendai Japan Summary The glomerular basement membrane of spontaneously diabetic rats was investigated by quantitative analysis using electron microscopy, with special reference to the effect of ageing. Constant agerelated increase in the width of basement membrane was ascertained both in diabetic and control rats, and the mean values of basement membrane thickness were always higher in the spontaneously diabetic rats than in normal control rats. Significant thickening of glomerular basement membrane was found in the diabetic rats at 12 weeks of age, while younger diabetic rats had no definite increase. The difference in basement membrane thickness between diabetic and normal control rats became larger with increasing age. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Diabetologia Springer Journals

Thickening of glomerular basement membrane in spontaneously diabetic rats

Diabetologia , Volume 15 (4) – Oct 1, 1978

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References (13)

Publisher
Springer Journals
Copyright
Copyright © 1978 by Springer-Verlag
Subject
Medicine & Public Health; Internal Medicine; Metabolic Diseases; Human Physiology
ISSN
0012-186X
eISSN
1432-0428
DOI
10.1007/BF02573824
Publisher site
See Article on Publisher Site

Abstract

125 15 15 4 4 S. Yagihashi Y. Goto M. Kakizaki N. Kaseda First Department of Pathology and Third Department of Internal Medicine Hirosaki University School of Medicine Hirosaki Japan Third Department of Internal Medicine Tohoku University School of Medicine Sendai Japan Summary The glomerular basement membrane of spontaneously diabetic rats was investigated by quantitative analysis using electron microscopy, with special reference to the effect of ageing. Constant agerelated increase in the width of basement membrane was ascertained both in diabetic and control rats, and the mean values of basement membrane thickness were always higher in the spontaneously diabetic rats than in normal control rats. Significant thickening of glomerular basement membrane was found in the diabetic rats at 12 weeks of age, while younger diabetic rats had no definite increase. The difference in basement membrane thickness between diabetic and normal control rats became larger with increasing age.

Journal

DiabetologiaSpringer Journals

Published: Oct 1, 1978

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