The time has come to target connective tissue growth factor in diabetic complications

The time has come to target connective tissue growth factor in diabetic complications Diabetologia (2004) 47:965–968 DOI 10.1007/s00125-004-1423-6 Commentary The time has come to target connective tissue growth factor in diabetic complications Dysregulation of growth factors is amongst the chang- leading to the hypothesis that CTGF contributes to es that occur in cells and tissues in diabetes. As early mesangial matrix expansion and the later chang- growth factors commonly control essential biological es of fibrosis in advanced diabetic nephropathy [10]. functions, it follows that they may be critical in caus- ECM expansion is a common feature in tissue af- ing the end-organ complications of diabetes [1]. Con- fected by diabetes. Indeed, we have recently shown sequently, identifying the key growth factor(s) that that CTGF is also increased in non-renal tissue. The cause a particular type and stage of diabetic tissue increases in CTGF correspond with pathological in- damage is of potential importance in preventing and creases in myocardial type III collagen in rodent dia- betic cardiomyopathy [11]. In the diabetic apoE-defi- treating diabetes complications. In this context, connective tissue growth factor cient mouse model of atheroma, CTGF mRNA and (CTGF), also known as CCN2 [2], is a prime candi- protein levels are increased in the complex lesions at date. Following its identification http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Diabetologia Springer Journals

The time has come to target connective tissue growth factor in diabetic complications

Diabetologia, Volume 47 (6) – Jun 1, 2004

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Publisher
Springer Journals
Copyright
Copyright © 2004 by Springer-Verlag
Subject
Medicine
ISSN
0012-186X
eISSN
1432-0428
DOI
10.1007/s00125-004-1423-6
Publisher site
See Article on Publisher Site

Abstract

Diabetologia (2004) 47:965–968 DOI 10.1007/s00125-004-1423-6 Commentary The time has come to target connective tissue growth factor in diabetic complications Dysregulation of growth factors is amongst the chang- leading to the hypothesis that CTGF contributes to es that occur in cells and tissues in diabetes. As early mesangial matrix expansion and the later chang- growth factors commonly control essential biological es of fibrosis in advanced diabetic nephropathy [10]. functions, it follows that they may be critical in caus- ECM expansion is a common feature in tissue af- ing the end-organ complications of diabetes [1]. Con- fected by diabetes. Indeed, we have recently shown sequently, identifying the key growth factor(s) that that CTGF is also increased in non-renal tissue. The cause a particular type and stage of diabetic tissue increases in CTGF correspond with pathological in- damage is of potential importance in preventing and creases in myocardial type III collagen in rodent dia- betic cardiomyopathy [11]. In the diabetic apoE-defi- treating diabetes complications. In this context, connective tissue growth factor cient mouse model of atheroma, CTGF mRNA and (CTGF), also known as CCN2 [2], is a prime candi- protein levels are increased in the complex lesions at date. Following its identification

Journal

DiabetologiaSpringer Journals

Published: Jun 1, 2004

References

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