Diabetologia (2004) 47:965–968 DOI 10.1007/s00125-004-1423-6 Commentary The time has come to target connective tissue growth factor in diabetic complications Dysregulation of growth factors is amongst the chang- leading to the hypothesis that CTGF contributes to es that occur in cells and tissues in diabetes. As early mesangial matrix expansion and the later chang- growth factors commonly control essential biological es of fibrosis in advanced diabetic nephropathy . functions, it follows that they may be critical in caus- ECM expansion is a common feature in tissue af- ing the end-organ complications of diabetes . Con- fected by diabetes. Indeed, we have recently shown sequently, identifying the key growth factor(s) that that CTGF is also increased in non-renal tissue. The cause a particular type and stage of diabetic tissue increases in CTGF correspond with pathological in- damage is of potential importance in preventing and creases in myocardial type III collagen in rodent dia- betic cardiomyopathy . In the diabetic apoE-defi- treating diabetes complications. In this context, connective tissue growth factor cient mouse model of atheroma, CTGF mRNA and (CTGF), also known as CCN2 , is a prime candi- protein levels are increased in the complex lesions at date. Following its identification
Diabetologia – Springer Journals
Published: Jun 1, 2004
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