Cognitive flexibility is a major requirement for successful goal-directed behavior and their neurobiological underpinnings are becoming better understood. However, the role of the norepinephrine system during task switching is largely enigmatic, despite neurobiological considerations make it likely that the norepinephrine system likely plays an important role. Theoretical considerations also suggest that the norepinephrine system mainly modulates task-switching processes when these rely upon working memory mechanisms. This topic was examined in the current system neurophysiological study integrating event-related potential (ERP) with pupil diameter data as a proximate the norepinephrine system activity. Combined with source localization methods, human brain structure, brain function, and phasic modulations by an important neurobiological system were integrated. The results show that cognitive-neurophysiological subprocesses during the actual switching processes, reflected by the N2 and P3 ERP components, are not modulated by the norepinephrine system. Rather, this system modulates preparatory processes in the fore period of stimuli signaling possible switches of response sets. The source localization results show that this is achieved by modulating neural processes in the temporo-parietal junction (BA40). Importantly, these phasic modulatory effects of the norepinephrine system were only evident when working memory processes had to be used to guide the selection of the appropriate responses for task switching.
Brain Structure and Function – Springer Journals
Published: Oct 12, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera