213 107 107 2 3 William A. Corrigall Keith B. J. Franklin Kathleen M. Coen Paul B. S. Clarke Neurobiology Section, Addiction Research Foundation M5S 2S1 Toronto Ontario Canada Department of Psychology McGill University H3A 1B1 Montreal Quebec Canada Department of Pharmacology and Therapeutics McGill University H3G 1Y6 Montreal Quebec Canada Abstract Rats were trained to self-administer nicotine on a fixed-ratio schedule of reinforcement. Infusion of the nicotinic antagonist chlorisondamine into the cerebral ventricles produced a sustained reduction in nicotine self-administration compared to vehicle-treated controls. Lesions of the mesolimbic dopamine system were produced by microinfusion of 6-hydroxydopamine into the nucleus accumbens. Following production of the lesions, nicotine self-administration was markedly reduced for the 3-week test period; motor impairment did not appear to be responsible. Post mortem analysis of brain tissue showed that the lesion produced a pronounced decrease in dopamine content of the nucleus accumbens and the olfactory tubercle, and a small depletion in the striatum. These data demonstrate that the reinforcing effects of nicotine occur within the central nervous system, and that the mesolimbic dopamine projection plays an important role in these effects.
Psychopharmacology – Springer Journals
Published: Jun 1, 1992
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