Purpose The renin-angiotensin system is involved in the sion does not influence levels of profibrotic cytokines/growth pathogenesis of fibrosis in several organs via induction of factors in aqueous humor. Further studies need to clarify if rele- transforming growth factor (TGF) beta. In the pathogenesis vant levels of ACEI accumulate in the eye, and if direct admin- of proliferative vitreoretinopathy (PVR) TGF-beta plays a piv- istration of ACEI in experimental PVR could be beneficial. otal role, promoting transition of retinal pigment epithelial . . (RPE) cells into myofibroblasts. We studied the influence of Keywords Proliferative vitreoretinopathy Treatment . . . angiotensin converting enzyme-inhibition (ACEI) on cyto- Angiotensin converting enzyme Renin Cytokines Growth kines and growth factors, related to PVR in aqueous humor. factors Methods We performed a post hoc analysis of a prospectively conducted interventional case series. From patients with rhegmatogenous retinal detachment (RRD) aqueous humor Introduction was obtained during primary surgery and analyzed using mul- tiplex bead analysis for interferon gamma, tumor necrosis fac- Proliferative vitreoretinopathy (PVR) is the leading cause for tor alpha, CC-chemokine ligand (CCL) 2 / monocyte failure of vitreoretinal surgery [1, 2]. Transforming growth chemoattractant protein (MCP)-1, interleukin (IL)-1 beta, IL- factor (TGF) beta plays
Graefe's Archive for Clinical and Experimental Ophthalmology – Springer Journals
Published: Jun 9, 2017
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