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M. Gąsior, R. Carter, J. Witkin (1999)
Neuroactive steroids: potential therapeutic use in neurological and psychiatric disorders.Trends in pharmacological sciences, 20 3
D. Marver, I. Edelman (1978)
Dihydrocortisol: a potential mineralocorticoid.Journal of steroid biochemistry, 9 1
Ashlee Stiles, D. Russell (2010)
SRD5A3: A Surprising Role in GlycosylationCell, 142
R. Agís-Balboa, A. Guidotti, G. Pinna (2014)
5α-reductase type I expression is downregulated in the prefrontal cortex/Brodmann’s area 9 (BA9) of depressed patientsPsychopharmacology, 231
Ying-li Lu, Lin-Yun Kuang, Huikang Zhu, Huixian Wu, Xue-fang Wang, Yuner Pang, Ning-jian Wang, Dan-lu Yu (2007)
Changes in aortic endothelium ultrastructure in male rats following castration, replacement with testosterone and administration of 5alpha-reductase inhibitor.Asian journal of andrology, 9 6
D. Eser, C. Schüle, T. Baghai, E. Romeo, D. Uzunov, Rainer Rupprecht (2006)
Neuroactive steroids and affective disordersPharmacology Biochemistry and Behavior, 84
C. Frye, A. Walf, M. Rhodes, J. Harney (2004)
Progesterone enhances motor, anxiolytic, analgesic, and antidepressive behavior of wild-type mice, but not those deficient in type 1 5α-reductaseBrain Research, 1004
S. Luchetti, K. Bossers, G. Frajese, D. Swaab (2010)
Neurosteroid Biosynthetic Pathway Changes in Substantia Nigra and Caudate Nucleus in Parkinson's DiseaseBrain Pathology, 20
D. Eser, E. Romeo, T. Baghai, F. Michele, C. Schüle, A. Pasini, P. Zwanzger, F. Padberg, R. Rupprecht (2006)
Neuroactive steroids as modulators of depression and anxietyNeuroscience, 138
N. Oakley (2000)
Dihydrotestosterone and the concept of 5α-reductase inhibition in human benign prostatic hyperplasia.Current Opinion in Urology, 10
Atrick, Alsh, Érald, Ndriole, Ichael, Ieber, Eter, Lbertsen, Laus, R. G., Oehrborn, Lice, T. M., Aylor, Oanne, Aldstreicher (2000)
THE EFFECT OF FINASTERIDE ON THE RISK OF ACUTE URINARY RETENTION AND THE NEED FOR SURGICAL TREATMENT AMONG MEN WITH BENIGN PROSTATIC HYPERPLASIA
N. Steen, P. Methlie, S. Lorentzen, I. Dieset, M. Aas, M. Nerhus, Marit Haram, I. Agartz, I. Melle, J. Berg, O. Andreassen (2014)
Altered systemic cortisol metabolism in bipolar disorder and schizophrenia spectrum disorders.Journal of psychiatric research, 52
L. Griffin, Wenhui Gong, L. Vérot, S. Mellon (2004)
Niemann–Pick type C disease involves disrupted neurosteroidogenesis and responds to allopregnanoloneNature Medicine, 10
D. Eser, C. Schüle, E. Romeo, T. Baghai, F. Michele, A. Pasini, P. Zwanzger, F. Padberg, R. Rupprecht (2006)
Neuropsychopharmacological properties of neuroactive steroids in depression and anxiety disordersPsychopharmacology, 186
Steven Kaplan, D. Chung, Richard Lee, S. Scofield, Alexis Te (2012)
A 5‐year retrospective analysis of 5α‐reductase inhibitors in men with benign prostatic hyperplasia: finasteride has comparable urinary symptom efficacy and prostate volume reduction, but less sexual side effects and breast complications than dutasterideInternational Journal of Clinical Practice, 66
Charles Gillespie, L. Almli, Alicia Smith, B. Bradley, Kimberly Kerley, Daniel Crain, Kristina Mercer, T. Weiss, J. Phifer, Yilang Tang, J. Cubells, E. Binder, K. Conneely, K. Ressler (2013)
Sex dependent influence of a functional polymorphism in steroid 5‐α‐reductase type 2 (SRD5A2) on post‐traumatic stress symptomsAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 162
Benjamin Sachs (1995)
Placing erection in context: The reflexogenic-psychogenic dichotomy reconsideredNeuroscience & Biobehavioral Reviews, 19
A. Traish, Kwangsung Park, Vinita Dhir, Noel Kim, R. Moreland, I. Goldstein (1999)
Effects of castration and androgen replacement on erectile function in a rabbit model.Endocrinology, 140 4
G. Andriole, D. Bostwick, O. Brawley, L. Gomella, M. Marberger, F. Montorsi, C. Pettaway, T. Tammela, C. Teloken, D. Tindall, M. Somerville, T. Wilson, I. Fowler, R. Rittmaster (2010)
Effect of dutasteride on the risk of prostate cancer.The New England journal of medicine, 362 13
C. Patte-Mensah, T. Penning, A. Mensah-Nyagan (2004)
Anatomical and cellular localization of neuroactive 5α/3α‐reduced steroid‐synthesizing enzymes in the spinal cordJournal of Comparative Neurology, 477
Finasteride for androgenetic alopecia and side effects
P. Siami, C. Roehrborn, J. Barkin, R. Damião, M. Wyczółkowski, A. Duggan, K. Major-Walker, B. Morrill (2007)
Combination therapy with dutasteride and tamsulosin in men with moderate-to-severe benign prostatic hyperplasia and prostate enlargement: the CombAT (Combination of Avodart and Tamsulosin) trial rationale and study design.Contemporary clinical trials, 28 6
R. Khisti, C. Chopde, Shirish Jain (2000)
Antidepressant-like effect of the neurosteroid 3α-hydroxy-5α-pregnan-20-one in mice forced swim testPharmacology Biochemistry and Behavior, 67
R. Melcangi, D. Caruso, F. Abbiati, S. Giatti, Donato Calabrese, F. Piazza, G. Cavaletti (2013)
Neuroactive steroid levels are modified in cerebrospinal fluid and plasma of post-finasteride patients showing persistent sexual side effects and anxious/depressive symptomatology.The journal of sexual medicine, 10 10
V. Cantagrel, D. Lefeber, B. Ng, Z. Guan, J. Silhavy, S. Bielas, L. Lehle, H. Hombauer, M. Adamowicz, E. Swiezewska, A. Brouwer, P. Blümel, J. Sykut-Cegielska, S. Houliston, Dominika Swistun, B. Ali, W. Dobyns, D. Babovic‐Vuksanovic, H. Bokhoven, R. Wevers, C. Raetz, H. Freeze, E. Morava, L. Al-Gazali, J. Gleeson (2010)
SRD5A3 Is Required for Converting Polyprenol to Dolichol and Is Mutated in a Congenital Glycosylation DisorderCell, 142
C. Chou, C-L. Lin, M.-C. Lin, F. Sung, C. Kao (2015)
5α-Reductase inhibitors increase acute coronary syndrome risk in patients with benign prostate hyperplasiaJournal of Endocrinological Investigation, 38
D. Eser, T. Baghai, C. Schüle, C. Nothdurfter, R. Rupprecht (2008)
Neuroactive steroids as endogenous modulators of anxiety.Current pharmaceutical design, 14 33
R. Rupprecht, A. Ströhle, B. Hermann, F. Michele, G. Spalletta, A. Pasini, F. Holsboer, E. Romeo (1998)
Neuroactive steroid concentrations following metyrapone administration in depressed patients and healthy volunteersBiological Psychiatry, 44
Elizabeth Yim, Katherine Nole, A. Tosti (2014)
5&agr;-Reductase inhibitors in androgenetic alopeciaCurrent Opinion in Endocrinology & Diabetes and Obesity, 21
C. Oztekin, S. Gur, N. Abdulkadir, U. Lokman, A. Akdemir, M. Çetinkaya, W. Hellstrom (2012)
Incomplete recovery of erectile function in rat after discontinuation of dual 5-alpha reductase inhibitor therapy.The journal of sexual medicine, 9 7
R. Rupprecht, F. Holsboer (1999)
Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectivesTrends in Neurosciences, 22
B. Hart (1979)
Activation of sexual reflexes of male rats by dihydrotestosterone but not estrogenPhysiology & Behavior, 23
E. Lephart (1995)
Age-related changes in brain and pituitary 5α-reductase with finasteride (Proscar) treatmentNeurobiology of Aging, 16
G. Altomare, G. Capella (2002)
Depression Circumstantially Related to the Administration of Finasteride for Androgenetic AlopeciaThe Journal of Dermatology, 29
(2003)
AUA guideline on management of benign prostatic hyperplasia (2003). Chapter 1: Diagnosis and treatment recommendations.The Journal of urology, 170 2 Pt 1
J. Naylor, J. Kilts, C. Hulette, D. Steffens, D. Blazer, J. Ervin, J. Strauss, T. Allen, M. Massing, V. Payne, N. Youssef, L. Shampine, C. Marx (2010)
Allopregnanolone levels are reduced in temporal cortex in patients with Alzheimer's disease compared to cognitively intact control subjects.Biochimica et biophysica acta, 1801 8
D. Reddy, M. Rogawski (2002)
Stress-Induced Deoxycorticosterone-Derived Neurosteroids Modulate GABAA Receptor Function and Seizure SusceptibilityThe Journal of Neuroscience, 22
W. Bradshaw, M. Baum, C. Awh (1981)
Attenuation by a 5a-Reductase Inhibitor of the Activational Effect of Testosterone Propionate on Penile Erections in Castrated Male Rats*Endocrinology, 109
D. Caruso, F. Abbiati, S. Giatti, Simone Romano, L. Fusco, G. Cavaletti, R. Melcangi (2015)
Patients treated for male pattern hair with finasteride show, after discontinuation of the drug, altered levels of neuroactive steroids in cerebrospinal fluid and plasmaThe Journal of Steroid Biochemistry and Molecular Biology, 146
Rita Upreti, Katherine Hughes, D. Livingstone, C. Gray, F. Minns, D. Macfarlane, I. Marshall, Laurence Stewart, B. Walker, R. Andrew (2014)
5α-Reductase Type 1 Modulates Insulin Sensitivity in MenThe Journal of Clinical Endocrinology and Metabolism, 99
F. Debruyne, G. Koch, P. Boyle, F. Silva, Jay Gillenwater, F. Hamdy, P. Perrin, P. Teillac, R. Vela-Navarrete, J. Raynaud (2002)
[Comparison of a phytotherapeutic agent (Permixon) with an alpha-blocker (Tamsulosin) in the treatment of benign prostatic hyperplasia: a 1-year randomized international study].Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie, 12 3
F. Noorbakhsh, G. Baker, C. Power (2014)
Allopregnanolone and neuroinflammation: a focus on multiple sclerosisFrontiers in Cellular Neuroscience, 8
B. Dubrovsky (2006)
Neurosteroids, neuroactive steroids, and symptoms of affective disordersPharmacology Biochemistry and Behavior, 84
H. Wessells, J. Roy, J. Bannow, J. Grayhack, A. Matsumoto, L. Tenover, R. Herlihy, W. Fitch, R. Labasky, S. Auerbach, R. Parra, J. Rajfer, J. Culbertson, Michael Lee, M. Bach, J. Waldstreicher (2003)
Incidence and severity of sexual adverse experiences in finasteride and placebo-treated men with benign prostatic hyperplasia.Urology, 61 3
E. Lephart (1995)
Age-related changes in brain and pituitary 5 alpha-reductase with finasteride (Proscar) treatment.Neurobiology of aging, 16 4
M. Shores, K. Sloan, A. Matsumoto, Victoria Moceri, B. Felker, D. Kivlahan (2004)
Increased incidence of diagnosed depressive illness in hypogonadal older men.Archives of general psychiatry, 61 2
R. Melcangi, A. Poletti, I. Cavarretta, F. Celotti, A. Colciago, V. Magnaghi, M. Motta, P. Negri‐Cesi, L. Martini (1998)
The 5alpha-reductase in the central nervous system: expression and modes of control.The Journal of steroid biochemistry and molecular biology, 65 1-6
M. Irwig (2015)
Safety concerns regarding 5&agr; reductase inhibitors for the treatment of androgenetic alopeciaCurrent Opinion in Endocrinology & Diabetes and Obesity, 22
Uygur Mc, E. Gür, Arik Ai, U. Altuǧ, Demokan Erol (2009)
Erectile dysfunction following treatments of benign prostatic hyperplasia: A prospective studyAndrologia, 30
G. Gray, Erla Smith, J. Davidson (1980)
Hormonal regulation of penile erection in castrated male ratsPhysiology & Behavior, 24
M. Pinsky, S. Gur, A. Tracey, A. Harbin, W. Hellstrom (2011)
The effects of chronic 5-alpha-reductase inhibitor (dutasteride) treatment on rat erectile function.The journal of sexual medicine, 8 11
D. Eser, C. Schüle, T. Baghai, E. Romeo, R. Rupprecht (2007)
Neuroactive Steroids in Depression and Anxiety Disorders: Clinical StudiesNeuroendocrinology, 84
A. Tosti, M. Pazzaglia, M. Soli, A. Rossi, A. Rebora, L. Atzori, M. Barbareschi, M. Benci, S. Voudouris, G. Vena (2004)
Evaluation of sexual function with an international index of erectile function in subjects taking finasteride for androgenetic alopecia.Archives of dermatology, 140 7
E. Romeo, A. Strohle, Augusto, Pasini, R. Conley, C. Tamminga, John, J. Bartko, C. Richardson, Michael, Peszke, Judith Hegerty, C. Gounaris, S. Zaremba, Charles Bradley, P. Duberstein (1998)
Effects of antidepressant treatment on neuroactive steroids in major depression.The American journal of psychiatry, 155 7
B. Stoffel‐Wagner (2001)
Neurosteroid metabolism in the human brain.European journal of endocrinology, 145 6
S. Andersson, D. Berman, E. Jenkins, D. Russell (1991)
Deletion of steroid 5α-reductase 2 gene in male pseudohermaphroditismNature, 354
Wen-Ling Lin, Yow-Wen Hsieh, Cheng-Li Lin, F. Sung, Chieh‐Hsi Wu, C. Kao (2015)
A population‐based nested case–control study: the use of 5‐alpha‐reductase inhibitors and the increased risk of osteoporosis diagnosis in patients with benign prostate hyperplasiaClinical Endocrinology, 82
R. Rupprecht, F. Michele, B. Hermann, A. Ströhle, M. Lancel, E. Romeo, F. Holsboer (2001)
Neuroactive steroids: molecular mechanisms of action and implications for neuropsychopharmacologyBrain Research Reviews, 37
C. Koonce, C. Frye (2013)
Progesterone facilitates exploration, affective and social behaviors among wildtype, but not 5α-reductase Type 1 mutant, miceBehavioural Brain Research, 253
S. Gur, P. Kadowitz, W. Hellstrom (2013)
Effects of 5-alpha reductase inhibitors on erectile function, sexual desire and ejaculationExpert Opinion on Drug Safety, 12
H. Garbán, D. Marquez, Liping Cai, J. Rajfer, N. Gonzalez-Cadavid (1995)
Restoration of normal adult penile erectile response in aged rats by long-term treatment with androgens.Biology of reproduction, 53 6
J. Tenover, G. Pagano, A. Morton, C. Liss, C. Byrnes (1997)
Efficacy and tolerability of finasteride in symptomatic benign prostatic hyperplasia: a primary care study. Primary Care Investigator Study Group.Clinical therapeutics, 19 2
Minguang Zhang, Xian-jin Wang, Zhoujun Shen, P. Gao (2013)
Basic and Translational Science Long-term Oral Administration of 5a-reductase Inhibitor Attenuates Erectile Function by Inhibiting Autophagy and Promoting Apoptosis of Smooth Muscle Cells in Corpus Cavernosum of Aged Rats
Y. Tsuji, Takahiro Nakayama, Keiko Bono, M. Kitamura, I. Imafuku (2014)
[Two cases of stroke associated with the use of finasteride, an approved drug for male-pattern hair loss in Japan].Rinsho shinkeigaku = Clinical neurology, 54 5
L. Galea, S. Wainwright, M. Roes, P. Duarte-Guterman, C. Chow, D. Hamson (2013)
Sex, Hormones and Neurogenesis in the Hippocampus: Hormonal Modulation of Neurogenesis and Potential Functional ImplicationsJournal of Neuroendocrinology, 25
C. Mantzoros, Emmanuel Georgiadis, D. Trichopoulos (1995)
Contribution of dihydrotestosterone to male sexual behaviourBMJ, 310
B. Römer, P. Gass (2010)
Finasteride‐induced depression: new insights into possible pathomechanismsJournal of Cosmetic Dermatology, 9
M. Schumacher, C. Mattern, A. Ghoumari, J. Oudinet, P. Liere, F. Labombarda, R. Sitruk-Ware, A. Nicola, R. Guennoun (2014)
Revisiting the roles of progesterone and allopregnanolone in the nervous system: Resurgence of the progesterone receptorsProgress in Neurobiology, 113
M. Wirth (2011)
Beyond the HPA Axis: Progesterone-Derived Neuroactive Steroids in Human Stress and EmotionFrontiers in Endocrinology, 2
J. Tenover, Grace Pagano, A. Morton, Charles Liss, Christine Byrnes (1997)
Efficacy and tolerability of finasteride in symptomatic benign prostatic hyperplasia: a primary care studyClinical Therapeutics, 19
A. Morrow (2007)
Recent developments in the significance and therapeutic relevance of neuroactive steroids--Introduction to the special issue.Pharmacology & therapeutics, 116 1
Benjamin Hart (1973)
Effects of testosterone propionate and dihydrotestosterone on penile morphology and sexual reflexes of spinal male rats.Hormones and behavior, 4 3
D. Reddy (2010)
Neurosteroids: endogenous role in the human brain and therapeutic potentials.Progress in brain research, 186
F. Desgrandchamps, S. Droupy, J. Irani, C. Saussine, A. Comenducci (2006)
Effect of dutasteride on the symptoms of benign prostatic hyperplasia, and patient quality of life and discomfort, in clinical practiceBJU International, 98
C. Roehrborn, P. Siami, J. Barkin, R. Damião, K. Major-Walker, B. Morrill, F. Montorsi (2008)
The effects of dutasteride, tamsulosin and combination therapy on lower urinary tract symptoms in men with benign prostatic hyperplasia and prostatic enlargement: 2-year results from the CombAT study.The Journal of urology, 179 2
W. Steers (2001)
5α-reductase activity in the prostateUrology, 58
M. Barbaccia, G. Roscetti, Marco Trabucchi, R. Purdy, M. Mostallino, A. Concas, G. Biggio (1997)
The effects of inhibitors of GABAergic transmission and stress on brain and plasma allopregnanolone concentrationsBritish Journal of Pharmacology, 120
R. Agís-Balboa, G. Pinna, Fabio Pibiri, B. Kadriu, E. Costa, A. Guidotti (2007)
Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in miceProceedings of the National Academy of Sciences, 104
M. Baum (1979)
A comparison of the effects of methyltrienolone (R 1881) and 5α-dihydrotestosterone on sexual behavior of castrated male ratsHormones and Behavior, 13
Jun-sheng Tian, Yuan-Lu Cui, Li-min Hu, Shan Gao, Wei Chi, T. Dong, Luyao Liu (2010)
Antidepressant-like effect of genipin in miceNeuroscience Letters, 479
M. Shores, D. Kivlahan, Tatiana Sadak, Ellen Li, A. Matsumoto (2009)
A randomized, double-blind, placebo-controlled study of testosterone treatment in hypogonadal older men with subthreshold depression (dysthymia or minor depression).The Journal of clinical psychiatry, 70 7
L. Wilton, G. Pearce, E. Edet, S. Freemantle, M. Stephens, R. Mann (1996)
The safety of finasteride used in benign prostatic hypertrophy: a non-interventional observational cohort study in 14,772 patients.British journal of urology, 78 3
Karl Normington, David Russell (1992)
Tissue distribution and kinetic characteristics of rat steroid 5 alpha-reductase isozymes. Evidence for distinct physiological functions.The Journal of biological chemistry, 267 27
Ian Thompson, P. Goodman, C. Tangen, M. Lucia, Gary Miller, Leslie Ford, Michael Lieber, R. Cespedes, James Atkins, Scott Lippman, Susie Carlin, A. Ryan, Connie Szczepanek, John Crowley, C. Coltman (2003)
The influence of finasteride on the development of prostate cancer.The New England journal of medicine, 349 3
C. Roehrborn, P. Boyle, J. Nickel, K. Hoefner, G. Andriole (2002)
Efficacy and safety of a dual inhibitor of 5-alpha-reductase types 1 and 2 (dutasteride) in men with benign prostatic hyperplasia.Urology, 60 3
(2006)
BMC Clinical Pharmacology BioMed Central
J. Manzo, M. Cruz, M. Hernández, P. Pacheco, B. Sachs (1999)
Regulation of Noncontact Erection in Rats by Gonadal SteroidsHormones and Behavior, 35
A.Leslie Morrow, P. Suzdak, Steven Paul (1987)
Steroid hormone metabolites potentiate GABA receptor-mediated chloride ion flux with nanomolar potency.European journal of pharmacology, 142 3
R. Melcangi, S. Giatti, Donato Calabrese, M. Pesaresi, G. Cermenati, N. Mitro, B. Viviani, L. Garcia-Segura, D. Caruso (2014)
Levels and actions of progesterone and its metabolites in the nervous system during physiological and pathological conditionsProgress in Neurobiology, 113
C. Frye, A. Walf (2004)
Hippocampal 3alpha,5alpha-THP may alter depressive behavior of pregnant and lactating rats.Pharmacology, biochemistry, and behavior, 78 3
R. McIntyre, D. Mancini, B. Eisfeld, J. Soczynska, L. Grupp, J. Konarski, S. Kennedy (2006)
Calculated bioavailable testosterone levels and depression in middle-aged menPsychoneuroendocrinology, 31
B. Stoffel‐Wagner (2003)
Neurosteroid Biosynthesis in the Human Brain and Its Clinical ImplicationsAnnals of the New York Academy of Sciences, 1007
T. Moore (2015)
Finasteride and the Uncertainties of Establishing Harms.JAMA dermatology, 151 6
S. Seo, S. Kim, J. Paick (1999)
The effects of androgen on penile reflex, erectile response to electrical stimulation and penile NOS activity in the rat.Asian journal of andrology, 1 4
(2002)
BMC Urology BioMed Central
L. Maimoun, P. Philibert, B. Cammas, F. Audran, P. Bouchard, P. Fénichel, M. Cartigny, C. Pienkowski, M. Polak, N. Skordis, I. Mazen, G. Ocal, M. Berberoğlu, R. Reynaud, C. Baumann, S. Cabrol, D. Simon, Kabangu Kayemba-Kay's, M. Kerdanet, F. Kurtz, B. Leheup, C. Heinrichs, S. Tenoutasse, G. Vliet, A. Grüters, M. Eunice, A. Ammini, M. Hafez, Z. Hochberg, S. Einaudi, Horia Mawlawi, Cristóbal Nuñez, N. Servant, S. Lumbroso, F. Paris, C. Sultan (2011)
Phenotypical, biological, and molecular heterogeneity of 5α-reductase deficiency: an extensive international experience of 55 patients.The Journal of clinical endocrinology and metabolism, 96 2
E. Morava, R. Wevers, V. Cantagrel, L. Hoefsloot, L. Al-Gazali, Jeroen Schoots, A. Rooij, Karin Huijben, C. Ravenswaaij-Arts, M. Jongmans, J. Sykut-Cegielska, G. Hoffmann, P. Bluemel, M. Adamowicz, J. Reeuwijk, B. Ng, J. Bergman, H. Bokhoven, C. Körner, D. Babovic‐Vuksanovic, M. Willemsen, J. Gleeson, L. Lehle, A. Brouwer, D. Lefeber (2010)
A novel cerebello-ocular syndrome with abnormal glycosylation due to abnormalities in dolichol metabolism.Brain : a journal of neurology, 133 11
A. Thigpen, R Silver, J Guileyardo, M Casey, J McConnell, D. Russell (1993)
Tissue distribution and ontogeny of steroid 5 alpha-reductase isozyme expression.The Journal of clinical investigation, 92 2
V. Uzunova, Y. Sheline, John Davis, A. Rasmusson, D. Uzunov, E. Costa, A. Guidotti (1998)
Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine.Proceedings of the National Academy of Sciences of the United States of America, 95 6
D. Russell, Jean Wilson (1994)
Steroid 5 alpha-reductase: two genes/two enzymes.Annual review of biochemistry, 63
Y. Saalmann, I. Morgan, M. Calford (2006)
Neurosteroids involved in regulating inhibition in the inferior colliculus.Journal of neurophysiology, 96 6
C. Roff, J. Strauss, E. Goldin, H. Jaffe, M. Patterson, G. Agritellis, A. Hibbs, M. Garfield, R. Brady, P. Pentchev (1993)
The murine Niemann-Pick type C lesion affects testosterone production.Endocrinology, 133 6
W. Bradshaw, M. Baum, C. Awh (1981)
Attenuation by a 5 alpha-reductase inhibitor of the activational effect of testosterone propionate on penile erections in castrated male rats.Endocrinology, 109 4
A. Traish, J. Hassani, A. Guay, M. Zitzmann, Michael Hansen (2011)
Adverse side effects of 5α-reductase inhibitors therapy: persistent diminished libido and erectile dysfunction and depression in a subset of patients.The journal of sexual medicine, 8 3
K. Park, SooWoong Kim, K.-W. Kim, J. Paick (1999)
Effects of androgens on the expression of nitric oxide synthase mRNAs in rat corpus cavernosumBJU International, 83
J. McHenry, N. Carrier, E. Hull, M. Kabbaj (2014)
Sex differences in anxiety and depression: Role of testosteroneFrontiers in Neuroendocrinology, 35
S. Saksena, I. Lau, M. Chang (1976)
The inhibition of the conversion of testosterone into 5α-dihydrotestosterone in the reproductive organs of the male ratSteroids, 27
J. Imperato-McGinley, Y. Zhu (2002)
Androgens and male physiology the syndrome of 5α-reductase-2 deficiencyMolecular and Cellular Endocrinology, 198
E. Baulieu (1998)
NEUROSTEROIDS: A NOVEL FUNCTION OF THE BRAINPsychoneuroendocrinology, 23
A. Poletti, A. Coscarella, P. Negri‐Cesi, A. Colciago, F. Celotti, L. Martini (1998)
5α-Reductase Isozymes in the Central Nervous SystemSteroids, 63
B. Römer, N. Pfeiffer, S. Lewicka, N. Ben-Abdallah, M. Vogt, M. Deuschle, B. Vollmayr, P. Gass (2010)
Finasteride Treatment Inhibits Adult Hippocampal Neurogenesis in Male MicePharmacopsychiatry, 43
S. Mellon, Wenhui Gong, L. Griffin (2004)
Niemann Pick Type C Disease as a Model for Defects in NeurosteroidogenesisEndocrine Research, 30
D. Livingstone, P. Barat, Emma Rollo, Georgina Rees, Benjamin Weldin, E. Rog-Zielinska, D. Macfarlane, B. Walker, R. Andrew (2014)
5α-Reductase Type 1 Deficiency or Inhibition Predisposes to Insulin Resistance, Hepatic Steatosis, and Liver Fibrosis in RodentsDiabetes, 64
J. Nickel, Y. Fradet, R. Boake, P. Pommerville, J. Perreault, S. Afridi, M. Elhilali (1996)
Efficacy and safety of finasteride therapy for benign prostatic hyperplasia: results of a 2-year randomized controlled trial (the PROSPECT study). PROscar Safety Plus Efficacy Canadian Two year Study.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 155 9
M. Irwig (2012)
Depressive symptoms and suicidal thoughts among former users of finasteride with persistent sexual side effects.The Journal of clinical psychiatry, 73 9
A. Traish, K. Haider, G. Doros, A. Haider (2015)
Finasteride, not tamsulosin, increases severity of erectile dysfunction and decreases testosterone levels in men with benign prostatic hyperplasiaHormone Molecular Biology and Clinical Investigation, 23
S. Belknap, I. Aslam, T. Kiguradze, W. Temps, P. Yarnold, J. Cashy, R. Brannigan, G. Micali, B. Nardone, D. West (2015)
Adverse Event Reporting in Clinical Trials of Finasteride for Androgenic Alopecia: A Meta-analysis.JAMA dermatology, 151 6
P. Pozzi, C. Bendotti, S. Simeoni, F. Piccioni, V. Guerini, T. Marron, L. Martini, A. Poletti (2003)
Androgen 5‐Alpha‐Reductase Type 2 is Highly Expressed and Active in Rat Spinal Cord Motor NeuronesJournal of Neuroendocrinology, 15
F. Noorbakhsh, K. Ellestad, F. Maingat, K. Warren, M. Han, L. Steinman, G. Baker, C. Power (2011)
Impaired neurosteroid synthesis in multiple sclerosis.Brain : a journal of neurology, 134 Pt 9
T. Yawno, Jonathan Hirst, M. Castillo-Melendez, David Walker (2009)
Role of neurosteroids in regulating cell death and proliferation in the late gestation fetal brainNeuroscience, 163
J. Lugg, J. Rajfer, N. Gonzalez-Cadavid (1995)
Dihydrotestosterone is the active androgen in the maintenance of nitric oxide-mediated penile erection in the rat.Endocrinology, 136 4
A. Traish, Ashwini Mulgaonkar, N. Giordano (2014)
The Dark Side of 5α-Reductase Inhibitors' Therapy: Sexual Dysfunction, High Gleason Grade Prostate Cancer and DepressionKorean Journal of Urology, 55
A. Ströhle, E. Romeo, B. Hermann, A. Pasini, G. Spalletta, F. Michele, F. Holsboer, R. Rupprecht (1999)
Concentrations of 3α-reduced neuroactive steroids and their precursors in plasma of patients with major depression and after clinical recoveryBiological Psychiatry, 45
A. Traish, A. Guay, M. Zitzmann (2014)
5α-Reductase inhibitors alter steroid metabolism and may contribute to insulin resistance, diabetes, metabolic syndrome and vascular disease: a medical hypothesisHormone Molecular Biology and Clinical Investigation, 20
G. Gormley, E. Stoner, R. Bruskewitz, J. Imperato-McGinley, P. Walsh, J. Mcconnell, G. Andriole, J. Geller, B. Bracken, J. Tenover (1992)
The effect of finasteride in men with benign prostatic hyperplasia.The Journal of urology, 149 4
M. Shores, Victoria Moceri, K. Sloan, A. Matsumoto, D. Kivlahan (2005)
Low testosterone levels predict incident depressive illness in older men: effects of age and medical morbidity.The Journal of clinical psychiatry, 66 1
J. Wang, Chanpreet Singh, Lifei Liu, R. Irwin, Shuhua Chen, E. Chung, Richard Thompson, R. Brinton (2010)
Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's diseaseProceedings of the National Academy of Sciences, 107
C. Fwu, P. Eggers, Z. Kirkali, K. McVary, P. Burrows, J. Kusek (2014)
Change in sexual function in men with lower urinary tract symptoms/benign prostatic hyperplasia associated with long-term treatment with doxazosin, finasteride and combined therapy.The Journal of urology, 191 6
J. Imperato-McGinley, Y. Zhu (2002)
Androgens and male physiology the syndrome of 5alpha-reductase-2 deficiency.Molecular and cellular endocrinology, 198 1-2
C. Frye, A. Walf (2004)
Hippocampal 3α,5α-THP may alter depressive behavior of pregnant and lactating ratsPharmacology Biochemistry and Behavior, 78
Meena Singh, M. Avram (2014)
Persistent sexual dysfunction and depression in finasteride users for male pattern hair loss: a serious concern or red herring?The Journal of clinical and aesthetic dermatology, 7 12
J. Melledo, G. Baker (2004)
Role of progesterone and other neuroactive steroids in anxiety disordersExpert Review of Neurotherapeutics, 4
A. Ali, B. Heran, M. Etminan (2015)
Persistent Sexual Dysfunction and Suicidal Ideation in Young Men Treated with Low‐Dose Finasteride: A Pharmacovigilance StudyPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 35
S. Windahl, N. Andersson, A. Börjesson, Charlotte Swanson, J. Svensson, S. Movérare-Skrtic, K. Sjögren, R. Shao, M. Lagerquist, C. Ohlsson (2011)
Reduced Bone Mass and Muscle Strength in Male 5α-Reductase Type 1 Inactivated MicePLoS ONE, 6
D. Finn, A. Beadles-Bohling, E. Beckley, M. Ford, Katherine Gililland, Rebecca Gorin-Meyer, K. Wiren (2006)
A new look at the 5alpha-reductase inhibitor finasteride.CNS drug reviews, 12 1
F. Padberg, F. Michele, P. Zwanzger, E. Romeo, G. Bernardi, C. Schüle, T. Baghai, R. Ella, A. Pasini, R. Rupprecht (2002)
Plasma Concentrations of Neuroactive Steroids before and after Repetitive Transcranial Magnetic Stimulation (rTMS) in Major DepressionNeuropsychopharmacology, 27
M. Biały, Benjamin Sachs (2002)
Androgen Implants in Medial Amygdala Briefly Maintain Noncontact Erection in Castrated Male RatsHormones and Behavior, 42
P. Cooke, Manjunatha Nanjappa, Zhihui Yang, Kevin Wang (2013)
Therapeutic effects of progesterone and its metabolites in traumatic brain injury may involve non-classical signaling mechanismsFrontiers in Neuroscience, 7
A. Traish (2012)
5α-reductases in human physiology: an unfolding story.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 18 6
R. Melcangi, G. Panzica (2014)
Allopregnanolone: State of the artProgress in Neurobiology, 113
K. Borowicz, Barbara Piskorska, M. Banach, S. Czuczwar (2011)
Neuroprotective Actions of NeurosteroidsFrontiers in Endocrinology, 2
Fahd Zarrouf, Steven Artz, J. Griffith, C. Sirbu, M. Kommor (2009)
Testosterone and Depression: Systematic Review and Meta-AnalysisJournal of Psychiatric Practice, 15
C. Schüle, D. Eser, T. Baghai, C. Nothdurfter, J. Kessler, R. Rupprecht (2011)
Neuroactive steroids in affective disorders: target for novel antidepressant or anxiolytic drugs?Neuroscience, 191
M. Marberger (1998)
Long-Term Effects of Finasteride in Patients with Benign Prostatic Hyperplasia: A Double-Blind, Placebo-Controlled, Multicenter StudyUrology, 51
5α-Reductase inhibitors (5α-RIs) such as finasteride and dutasteride have proven useful in clinical management of lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) and also in treatment of androgenetic alopecia (AGA). However, these drugs have serious and, in some patients, persistent or irreversible sexual side effects. These agents interfere with the biosynthesis and metabolism of neurosteroids and may adversely affect mood, stress, and anxiety and potentiate the onset of depression. Data from preclinical and clinical studies have provided substantial evidence that these agents cause loss or reduction of libido, increase the risk of erectile dysfunction and ejaculatory dysfunction, and may contribute to the onset of depression. It is imperative that clinicians give serious considerations to these adverse effects and their impact on patients’ health and engage their patients in an open and honest discussion regarding the potential harm of these agents prior to prescribing them.
Current Sexual Health Reports – Springer Journals
Published: Aug 26, 2015
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