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The effect of amantadine and (+)-amphetamine on motility in rats after inhibition of monoamine synthesis and storage

The effect of amantadine and (+)-amphetamine on motility in rats after inhibition of monoamine... 213 29 29 1 1 J. Buus Lassen Department of Pharmacology A/S Ferrosan DK 2860 Soeborg Denmark Abstract The effect of amantadine and (+)-amphetamine on motility was investigated by subcutaneous administration to rats. Amantadine 50 and 100 mg/kg induced a moderate increase of motility. (+)-amphetamine 1, 2.5 and 5 mg/kg showed a more potent locomotor stimulant effect. A stereotyped licking was found during the hypermotility induced by (+)-amphetamine 5 mg/kg. Pretreatment with the catecholamine synthesis inhibitor α -methyl-p-tyrosine inhibited the effect of (+)-amphetamine but not that of amantadine. Reserpine potentiated the effects of both amantadine and (+)-amphetamine. Tetrabenazine antagonized the hyperactivity produced by (+)-amphetamine but potentiated amantadine induced hyperactivity. The locomotor stimulant effect of amantadine seems to differ in certain respects from that of amphetamine. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

The effect of amantadine and (+)-amphetamine on motility in rats after inhibition of monoamine synthesis and storage

Psychopharmacology , Volume 29 (1) – Mar 1, 1973

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References (40)

Publisher
Springer Journals
Copyright
Copyright © 1973 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF00421211
Publisher site
See Article on Publisher Site

Abstract

213 29 29 1 1 J. Buus Lassen Department of Pharmacology A/S Ferrosan DK 2860 Soeborg Denmark Abstract The effect of amantadine and (+)-amphetamine on motility was investigated by subcutaneous administration to rats. Amantadine 50 and 100 mg/kg induced a moderate increase of motility. (+)-amphetamine 1, 2.5 and 5 mg/kg showed a more potent locomotor stimulant effect. A stereotyped licking was found during the hypermotility induced by (+)-amphetamine 5 mg/kg. Pretreatment with the catecholamine synthesis inhibitor α -methyl-p-tyrosine inhibited the effect of (+)-amphetamine but not that of amantadine. Reserpine potentiated the effects of both amantadine and (+)-amphetamine. Tetrabenazine antagonized the hyperactivity produced by (+)-amphetamine but potentiated amantadine induced hyperactivity. The locomotor stimulant effect of amantadine seems to differ in certain respects from that of amphetamine.

Journal

PsychopharmacologySpringer Journals

Published: Mar 1, 1973

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