The clinical utility of prostate cancer heterogeneity using texture analysis of multiparametric MRI

The clinical utility of prostate cancer heterogeneity using texture analysis of multiparametric MRI Purpose To determine if multiparametric MRI (mpMRI) derived filtration-histogram based texture analysis (TA) can dif- ferentiate between different Gleason scores (GS) and the D’Amico risk in prostate cancer. Methods We retrospectively studied patients whose pre-operative 1.5T mpMRI had shown a visible tumour and who subse- quently underwent radical prostatectomy (RP). Guided by tumour location from the histopathology report, we drew a region of interest around the dominant visible lesion on a single axial slice on the T2, Apparent Diffusion Coefficient (ADC) map and early arterial phase post-contrast T1 image. We then performed TA with a filtration-histogram software (TexRAD -Feedback Medical Ltd, Cambridge, UK). We correlated GS and D’Amico risk with texture using the Spearman’s rank correlation test. Results We had 26 RP patients with an MR-visible tumour. Mean of positive pixels (MPP) on ADC showed a significant negative correlation with GS at coarse texture scales. MPP showed a significant negative correlation with GS without fil- tration and with medium filtration. MRI contrast texture without filtration showed a significant, negative correlation with D’Amico score. MR T2 texture showed a significant, negative correlation with the D’Amico risk, particularly at textures without filtration, medium texture scales and coarse texture scales. Conclusion ADC http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Urology and Nephrology Springer Journals

The clinical utility of prostate cancer heterogeneity using texture analysis of multiparametric MRI

Loading next page...
 
/lp/springer-journals/the-clinical-utility-of-prostate-cancer-heterogeneity-using-texture-7ttbrCywUh
Publisher
Springer Journals
Copyright
Copyright © 2019 by Springer Nature B.V.
ISSN
0301-1623
eISSN
1573-2584
D.O.I.
10.1007/s11255-019-02134-0
Publisher site
See Article on Publisher Site

Abstract

Purpose To determine if multiparametric MRI (mpMRI) derived filtration-histogram based texture analysis (TA) can dif- ferentiate between different Gleason scores (GS) and the D’Amico risk in prostate cancer. Methods We retrospectively studied patients whose pre-operative 1.5T mpMRI had shown a visible tumour and who subse- quently underwent radical prostatectomy (RP). Guided by tumour location from the histopathology report, we drew a region of interest around the dominant visible lesion on a single axial slice on the T2, Apparent Diffusion Coefficient (ADC) map and early arterial phase post-contrast T1 image. We then performed TA with a filtration-histogram software (TexRAD -Feedback Medical Ltd, Cambridge, UK). We correlated GS and D’Amico risk with texture using the Spearman’s rank correlation test. Results We had 26 RP patients with an MR-visible tumour. Mean of positive pixels (MPP) on ADC showed a significant negative correlation with GS at coarse texture scales. MPP showed a significant negative correlation with GS without fil- tration and with medium filtration. MRI contrast texture without filtration showed a significant, negative correlation with D’Amico score. MR T2 texture showed a significant, negative correlation with the D’Amico risk, particularly at textures without filtration, medium texture scales and coarse texture scales. Conclusion ADC

Journal

International Urology and NephrologySpringer Journals

Published: Mar 30, 2019

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off