Purpose To determine if multiparametric MRI (mpMRI) derived filtration-histogram based texture analysis (TA) can dif- ferentiate between different Gleason scores (GS) and the D’Amico risk in prostate cancer. Methods We retrospectively studied patients whose pre-operative 1.5T mpMRI had shown a visible tumour and who subse- quently underwent radical prostatectomy (RP). Guided by tumour location from the histopathology report, we drew a region of interest around the dominant visible lesion on a single axial slice on the T2, Apparent Diffusion Coefficient (ADC) map and early arterial phase post-contrast T1 image. We then performed TA with a filtration-histogram software (TexRAD -Feedback Medical Ltd, Cambridge, UK). We correlated GS and D’Amico risk with texture using the Spearman’s rank correlation test. Results We had 26 RP patients with an MR-visible tumour. Mean of positive pixels (MPP) on ADC showed a significant negative correlation with GS at coarse texture scales. MPP showed a significant negative correlation with GS without fil- tration and with medium filtration. MRI contrast texture without filtration showed a significant, negative correlation with D’Amico score. MR T2 texture showed a significant, negative correlation with the D’Amico risk, particularly at textures without filtration, medium texture scales and coarse texture scales. Conclusion ADC
International Urology and Nephrology – Springer Journals
Published: Mar 30, 2019
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