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The authors' reply

The authors' reply Diabetologia (2002) 45:1604 DOI 10.1007/s00125-002-0966-7 * P. Arner and J. Hoffstedt wrote this letter on behalf of the co- authors of the original article To the Editor: Freeman and Mansfield find our conclusions on P. Arner, J. Hoffstedt the association between the –675 4G/5G PAI-1 polymorphism and obesity, recently published [1], to be overstated. This state- ment is based on their study showing no difference in genotype References frequency between lean, overweight or obese subjects [2]. However, several questions arise as to interpreting their re- 1. Hoffstedt J, Andersson I-L, Persson L, Isaksson B, Arner P sults. Firstly, the genotype distribution differed from the Har- (2002) The common –675 4G/5G polymorphism in the plas- dy-Weinberg equilibrium, which makes the genotyping doubt- minogen activator inhibitor-1 gene is strongly associated ful. Secondly, a family-based cohort is suitable for linkage, but with obesity. Diabetologia 45: 584–587 not association, studies. Finally, given these shortcomings it 2. Freeman MS, Mansfield MW, Barett JH, Grant PJ (2002) should be noted that in the Freeman and Mansfield study, the Genetic contribution to circulating levels of hemostatic fac- 4G/4G genotype was almost twice as common as the 5G/5G tors in healthy families with effects of known genetic http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Diabetologia Springer Journals

The authors' reply

Arner, P.; Hoffstedt, J.
Diabetologia , Volume 45 (11) – Nov 1, 2002
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The authors' reply

Abstract

Diabetologia (2002) 45:1604 DOI 10.1007/s00125-002-0966-7 * P. Arner and J. Hoffstedt wrote this letter on behalf of the co- authors of the original article To the Editor: Freeman and Mansfield find our conclusions on P. Arner, J. Hoffstedt the association between the –675 4G/5G PAI-1 polymorphism and obesity, recently published [1], to be overstated. This state- ment is based on their study showing no difference in genotype References frequency between lean, overweight or obese...
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References (2)

Publisher
Springer Journals
Copyright
Copyright © 2002 by Springer-Verlag
Subject
Legacy
ISSN
0012-186X
eISSN
1432-0428
DOI
10.1007/s00125-002-0966-7
Publisher site
See Article on Publisher Site

Abstract

Diabetologia (2002) 45:1604 DOI 10.1007/s00125-002-0966-7 * P. Arner and J. Hoffstedt wrote this letter on behalf of the co- authors of the original article To the Editor: Freeman and Mansfield find our conclusions on P. Arner, J. Hoffstedt the association between the –675 4G/5G PAI-1 polymorphism and obesity, recently published [1], to be overstated. This state- ment is based on their study showing no difference in genotype References frequency between lean, overweight or obese subjects [2]. However, several questions arise as to interpreting their re- 1. Hoffstedt J, Andersson I-L, Persson L, Isaksson B, Arner P sults. Firstly, the genotype distribution differed from the Har- (2002) The common –675 4G/5G polymorphism in the plas- dy-Weinberg equilibrium, which makes the genotyping doubt- minogen activator inhibitor-1 gene is strongly associated ful. Secondly, a family-based cohort is suitable for linkage, but with obesity. Diabetologia 45: 584–587 not association, studies. Finally, given these shortcomings it 2. Freeman MS, Mansfield MW, Barett JH, Grant PJ (2002) should be noted that in the Freeman and Mansfield study, the Genetic contribution to circulating levels of hemostatic fac- 4G/4G genotype was almost twice as common as the 5G/5G tors in healthy families with effects of known genetic

Journal

Diabetologia – Springer Journals

Published: Nov 1, 2002

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