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The anti-oestrogen tamoxifen is a calcium antagonist in perfused rat mesentery

Authors

Abstract

280 20 20 2 2 A. Lipton Efamol Research Institute P.O. Box 818 B4N 4H8 Nova Scotia Canada Department of Physiology and Pharmacology University of Queensland 4067 Brisbane Queensland Australia Summary The anti-oestrogen tamoxifen in the range 10 -7 –10 -5 M induced concentration-related inhibition of potassium-stimulated vasospasm in the isolated perfused rat mesentery vascular bed. In contrast, responses to noradrenaline did not fall below control levels until the tamoxifen concentration exceeded 4x10 -6 M . Recovery of the potassium-stimulated responses was also concentration-related. The most likely explanation is that while tamoxifen can obstruct the entry of extracellular calcium, it is unable to prevent the intracellular release of the ion by noradrenaline.

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Journal

Cancer Chemotherapy and PharmacologySpringer Journals

Published: Oct 1, 1987

DOI: 10.1007/BF00253965

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