The action of glycine on cortical neurones

The action of glycine on cortical neurones 221 9 9 2 2 J. S. Kelly K. Krnjević Department of Research in Anaesthesia McGill University Montreal Quebec Canada Summary 1. Microiontophoretic applications on cortical neurones in the “cerveaux isolés” of cats show that glycine is only 1/4 as potent as GABA in blocking glutamate-evoked discharges. 2. Glycine produces only relatively slight changes in the membrane conductance of cortical neurones. Its action falls off rapidly during a prolonged application. 3. In most cases, glycine produces either no clear change in membrane potential or a small depolarization. Although there is a positive correlation between the IPSP reversal potential (E I ) and the reversal potential for the effect of glycine (E GLY ), E GLY is usually much more positive than E I . 4. Glycine causes no gross interference with the action of GABA or with cortical IPSPs. 5. It is concluded that glycine is unlikely to play a major role in cortical inhibition. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Experimental Brain Research Springer Journals

The action of glycine on cortical neurones

Experimental Brain Research, Volume 9 (2) – Oct 1, 1969

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Publisher
Springer Journals
Copyright
Copyright © 1969 by Springer-Verlag
Subject
Biomedicine; Neurosciences; Neurology
ISSN
0014-4819
eISSN
1432-1106
DOI
10.1007/BF00238328
Publisher site
See Article on Publisher Site

Abstract

221 9 9 2 2 J. S. Kelly K. Krnjević Department of Research in Anaesthesia McGill University Montreal Quebec Canada Summary 1. Microiontophoretic applications on cortical neurones in the “cerveaux isolés” of cats show that glycine is only 1/4 as potent as GABA in blocking glutamate-evoked discharges. 2. Glycine produces only relatively slight changes in the membrane conductance of cortical neurones. Its action falls off rapidly during a prolonged application. 3. In most cases, glycine produces either no clear change in membrane potential or a small depolarization. Although there is a positive correlation between the IPSP reversal potential (E I ) and the reversal potential for the effect of glycine (E GLY ), E GLY is usually much more positive than E I . 4. Glycine causes no gross interference with the action of GABA or with cortical IPSPs. 5. It is concluded that glycine is unlikely to play a major role in cortical inhibition.

Journal

Experimental Brain ResearchSpringer Journals

Published: Oct 1, 1969

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