221 9 9 2 2 J. S. Kelly K. Krnjević Department of Research in Anaesthesia McGill University Montreal Quebec Canada Summary 1. Microiontophoretic applications on cortical neurones in the “cerveaux isolés” of cats show that glycine is only 1/4 as potent as GABA in blocking glutamate-evoked discharges. 2. Glycine produces only relatively slight changes in the membrane conductance of cortical neurones. Its action falls off rapidly during a prolonged application. 3. In most cases, glycine produces either no clear change in membrane potential or a small depolarization. Although there is a positive correlation between the IPSP reversal potential (E I ) and the reversal potential for the effect of glycine (E GLY ), E GLY is usually much more positive than E I . 4. Glycine causes no gross interference with the action of GABA or with cortical IPSPs. 5. It is concluded that glycine is unlikely to play a major role in cortical inhibition.
Experimental Brain Research – Springer Journals
Published: Oct 1, 1969
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