Synthesis and production of the antitumor polyketide aurovertins and structurally related compounds

Synthesis and production of the antitumor polyketide aurovertins and structurally related compounds Aurovertins belong to a family of highly reducing polyketides sharing a polyene α-pyrone-type structure. These compounds comprise aurovertin, asteltoxin, avertoxin, citreoviridin, verrucosidin, and their derivatives, which exihibit potent antitumor, antiviral, and antibacterial activities. Until now, over 40 aurovertins and structurally related compounds have been found in the fungal kingdom. Due to the unique structural feature and interesting bioactivities, significant progresses have been achieved for the structural identification, chemical synthesis, and biosynthesis of the mentioned compounds. Understanding of aurovertin biosynthetic mechanism provides a solid basis for engineering the metabolic pathway of those compounds by rational design and realizing their production in the model fungal host. . . . . Keywords Natural products Aurovertin Polyketide Antitumor activity Biosynthesis Introduction phosphorylation by binding to β subunit of F1-ATPase (van Raaijetal. 1996). Therefore, it has been implicated as a poten- Aurovertins are highly reduced polyketides containing a 2,6- tial therapeutic agent against breast cancer (Huang et al. 2008). dioxabicyclo [3.2.1] octane (DBO) core structure attached to a Due to their unusual structures and interesting bioactivities, methylated α-pyrone via a triene linker. Since the identification aurovertins have strongly attracted considerable attentions. of aurovertins A-D (1–4)in1964(Baldwinetal. 1964), over 40 Total synthesis and biosynthesis of aurovertins http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Microbiology and Biotechnology Springer Journals

Synthesis and production of the antitumor polyketide aurovertins and structurally related compounds

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2018 by Springer-Verlag GmbH Germany, part of Springer Nature
Subject
Life Sciences; Microbiology; Microbial Genetics and Genomics; Biotechnology
ISSN
0175-7598
eISSN
1432-0614
D.O.I.
10.1007/s00253-018-9123-1
Publisher site
See Article on Publisher Site

Abstract

Aurovertins belong to a family of highly reducing polyketides sharing a polyene α-pyrone-type structure. These compounds comprise aurovertin, asteltoxin, avertoxin, citreoviridin, verrucosidin, and their derivatives, which exihibit potent antitumor, antiviral, and antibacterial activities. Until now, over 40 aurovertins and structurally related compounds have been found in the fungal kingdom. Due to the unique structural feature and interesting bioactivities, significant progresses have been achieved for the structural identification, chemical synthesis, and biosynthesis of the mentioned compounds. Understanding of aurovertin biosynthetic mechanism provides a solid basis for engineering the metabolic pathway of those compounds by rational design and realizing their production in the model fungal host. . . . . Keywords Natural products Aurovertin Polyketide Antitumor activity Biosynthesis Introduction phosphorylation by binding to β subunit of F1-ATPase (van Raaijetal. 1996). Therefore, it has been implicated as a poten- Aurovertins are highly reduced polyketides containing a 2,6- tial therapeutic agent against breast cancer (Huang et al. 2008). dioxabicyclo [3.2.1] octane (DBO) core structure attached to a Due to their unusual structures and interesting bioactivities, methylated α-pyrone via a triene linker. Since the identification aurovertins have strongly attracted considerable attentions. of aurovertins A-D (1–4)in1964(Baldwinetal. 1964), over 40 Total synthesis and biosynthesis of aurovertins

Journal

Applied Microbiology and BiotechnologySpringer Journals

Published: Jun 2, 2018

References

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