Keywords Atom economy Multicomponent reactions Sulfamic acid 2-Amino pyridine Naphthydrin derivatives Introduction Multistep synthesis of complex organic molecules does not meet the criteria of green chemistry because of several drawbacks such as the generation of waste, longer reaction time, low yield, tedious work-up procedure, etc. To overcome this issue, the scientiﬁc community has recently turned their attention towards an enviro- economic synthesis. Multicomponent reactions (MCRs) are ideal tools to overcome these drawbacks due to their remarkable advantages like high convergence, operational simplicity, facile automation, efﬁcient work-up procedure, minimum waste generation, and enhancement atom economics rendering the protocol green [1, 2]. MCRs strategy has been realized to be a powerful means of developing drug- like heterocyclic compounds with high levels of diversity and molecular complex- ity, thereby facilitating optimization in organic synthesis [3, 4]. Therefore, the design of new MCRs with green procedures has attracted great attention, particularly in the areas of organic synthesis [5–9]. The naphthydrin skeleton, being a crucial pharmacophore present in various synthetic compounds as well as in natural products, has attracted considerable attention . Neozeylanicine from the wood of Neonaucleazeylanica [11, 12], naphthyridiyl methyl ketone from Valeriana ofﬁcinalis [13, 14], jasminine and
Research on Chemical Intermediates – Springer Journals
Published: Oct 20, 2016
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