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Successful Treatment of Refractory Majocchi’s Granuloma with Voriconazole and Review of Published Literature

Successful Treatment of Refractory Majocchi’s Granuloma with Voriconazole and Review of Published... Majocchi’s granuloma (MG) is a rare deep skin dermatophyte infection that can occur either in immunocompetent or in immunocompromised individuals. Oral itraconazole or terbinafine is considered to be the first choice of treatment. We report an immunocompetent man with deep nodular form of MG, the form which is generally found in immunosuppressed individuals. Previous treatment with either oral itraconazole or terbinafine yielded no apparent improvement. After a series of examination, the man was diagnosed as having Trichophyton rubrum-induced MG mixed with bacterial infection as evidenced by growth of Klebsiella pneumoniae in tissue bacterial culture. The patient was treated with a combination of cefoselis and levofloxacin for bacterial clearance followed by voriconazole treatment. After approximately 4 months of voriconazole treatment, the lesions completely resolved. Alternative medicine (voriconazole) can be considered in case of refractory infections during MG treatment. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mycopathologia Springer Journals

Successful Treatment of Refractory Majocchi’s Granuloma with Voriconazole and Review of Published Literature

Mycopathologia , Volume 180 (4) – Jun 5, 2015

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References (34)

Publisher
Springer Journals
Copyright
Copyright © 2015 by Springer Science+Business Media Dordrecht
Subject
Life Sciences; Microbiology; Medical Microbiology; Eukaryotic Microbiology; Microbial Ecology; Plant Sciences
ISSN
0301-486X
eISSN
1573-0832
DOI
10.1007/s11046-015-9902-5
pmid
26045285
Publisher site
See Article on Publisher Site

Abstract

Majocchi’s granuloma (MG) is a rare deep skin dermatophyte infection that can occur either in immunocompetent or in immunocompromised individuals. Oral itraconazole or terbinafine is considered to be the first choice of treatment. We report an immunocompetent man with deep nodular form of MG, the form which is generally found in immunosuppressed individuals. Previous treatment with either oral itraconazole or terbinafine yielded no apparent improvement. After a series of examination, the man was diagnosed as having Trichophyton rubrum-induced MG mixed with bacterial infection as evidenced by growth of Klebsiella pneumoniae in tissue bacterial culture. The patient was treated with a combination of cefoselis and levofloxacin for bacterial clearance followed by voriconazole treatment. After approximately 4 months of voriconazole treatment, the lesions completely resolved. Alternative medicine (voriconazole) can be considered in case of refractory infections during MG treatment.

Journal

MycopathologiaSpringer Journals

Published: Jun 5, 2015

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