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Studies on the mechanism of insulin action: Basic concepts and clinical implications

Studies on the mechanism of insulin action: Basic concepts and clinical implications Diabetologia 13, 177-186 (1977) Diabetologia 9 by Springer-Verlag 1977 Review Articles K.D. Hepp Forschergruppe Diabetes trod III. Medizinische Klinik des Krankenhauses Schwabing, Miinchen, FRG Key words: Insulin, receptor binding, diabetes, Sepharose-coupled insulin, PVP-coupled insulin, Chinese hamster, streptozotocin-diabetes, liver membranes, translation of hormone-receptor interaction, 3',5'-AMP in fat cells, catecholamines, adenylate cyclase, phosphodiesterase, NSILA-S, 3',5'-GMP, calcium, local anaesthetics. With the observation that pancreatectomy leads to the development of diabetes, Minkowski together with von Mehring paved the way to the discovery of insulin [1]. It was thus a straight road from the Strassburg of 1889 to the Toronto of 1921, and it seems appropriate to pay homage to the genius of Oskar Minkowski with a lecture on the mechanism of the action of insulin. Two aspects of the complex problem of this insulin action have especially interested us over the last few years: the binding of the hormone to membranes with the possibility of a receptor defect in diabetes, and the quest for a primary effect upon enzyme systems in the plasma membrane of target cells. Receptor Binding and Receptor Defect The first stage in the mechanism of action of insulin is binding to specific sites in the plasma membrane. Many http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Diabetologia Springer Journals

Studies on the mechanism of insulin action: Basic concepts and clinical implications

Hepp, K.
Diabetologia , Volume 13 (3) – May 1, 1977
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References (65)

Publisher
Springer Journals
Copyright
Copyright © 1977 by Springer-Verlag
Subject
Medicine & Public Health; Human Physiology; Internal Medicine; Metabolic Diseases
ISSN
0012-186X
eISSN
1432-0428
DOI
10.1007/BF01219697
Publisher site
See Article on Publisher Site

Abstract

Diabetologia 13, 177-186 (1977) Diabetologia 9 by Springer-Verlag 1977 Review Articles K.D. Hepp Forschergruppe Diabetes trod III. Medizinische Klinik des Krankenhauses Schwabing, Miinchen, FRG Key words: Insulin, receptor binding, diabetes, Sepharose-coupled insulin, PVP-coupled insulin, Chinese hamster, streptozotocin-diabetes, liver membranes, translation of hormone-receptor interaction, 3',5'-AMP in fat cells, catecholamines, adenylate cyclase, phosphodiesterase, NSILA-S, 3',5'-GMP, calcium, local anaesthetics. With the observation that pancreatectomy leads to the development of diabetes, Minkowski together with von Mehring paved the way to the discovery of insulin [1]. It was thus a straight road from the Strassburg of 1889 to the Toronto of 1921, and it seems appropriate to pay homage to the genius of Oskar Minkowski with a lecture on the mechanism of the action of insulin. Two aspects of the complex problem of this insulin action have especially interested us over the last few years: the binding of the hormone to membranes with the possibility of a receptor defect in diabetes, and the quest for a primary effect upon enzyme systems in the plasma membrane of target cells. Receptor Binding and Receptor Defect The first stage in the mechanism of action of insulin is binding to specific sites in the plasma membrane. Many

Journal

Diabetologia – Springer Journals

Published: May 1, 1977

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