213 125 125 1 1 S. Maurel Remy R. Schreiber M. Dalmus J. De Vry Institute for Neurobiology, Troponwerke GmbH & Co. KG Berliner Strasse 156 D-51063 Köln Germany Abstract In the rat shock-induced ultrasonic vocalization test, the anxiolytic effects of the 5-HT 1A receptor agonist 8-hydroxy-2-(di- n -propylamino)tetralin (8-OH-DPAT) obtained after systemic (IP) and intracerebral injection into the dorsal raphe nucleus (DRN) were selectively abolished by pretreatment with the 5-HT 1A receptor antagonist WAY-100635 ( N -(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)- N -(2-pyridinyl) cyclo-hexanecarboxamide trihydrochloride). This blockade was demonstrated both after systemic and DRN application of WAY-100635. Therefore, it is concluded that the anxiolytic effects of 8-OH-DPAT are mediated by activation of somatodendritic 5-HT 1A receptors.
Psychopharmacology – Springer Journals
Published: May 1, 1996
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