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Somatodendritic 5-HT 1A receptors are critically involved in the anxiolytic effects of 8-OH-DPAT

Somatodendritic 5-HT 1A receptors are critically involved in the anxiolytic effects of 8-OH-DPAT 213 125 125 1 1 S. Maurel Remy R. Schreiber M. Dalmus J. De Vry Institute for Neurobiology, Troponwerke GmbH & Co. KG Berliner Strasse 156 D-51063 Köln Germany Abstract In the rat shock-induced ultrasonic vocalization test, the anxiolytic effects of the 5-HT 1A receptor agonist 8-hydroxy-2-(di- n -propylamino)tetralin (8-OH-DPAT) obtained after systemic (IP) and intracerebral injection into the dorsal raphe nucleus (DRN) were selectively abolished by pretreatment with the 5-HT 1A receptor antagonist WAY-100635 ( N -(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)- N -(2-pyridinyl) cyclo-hexanecarboxamide trihydrochloride). This blockade was demonstrated both after systemic and DRN application of WAY-100635. Therefore, it is concluded that the anxiolytic effects of 8-OH-DPAT are mediated by activation of somatodendritic 5-HT 1A receptors. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Somatodendritic 5-HT 1A receptors are critically involved in the anxiolytic effects of 8-OH-DPAT

Remy, S.; Schreiber, R.; Dalmus, M.; Vry, J.
Psychopharmacology , Volume 125 (1) – May 1, 1996
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References (7)

Publisher
Springer Journals
Copyright
Copyright © 1996 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF02247397
Publisher site
See Article on Publisher Site

Abstract

213 125 125 1 1 S. Maurel Remy R. Schreiber M. Dalmus J. De Vry Institute for Neurobiology, Troponwerke GmbH & Co. KG Berliner Strasse 156 D-51063 Köln Germany Abstract In the rat shock-induced ultrasonic vocalization test, the anxiolytic effects of the 5-HT 1A receptor agonist 8-hydroxy-2-(di- n -propylamino)tetralin (8-OH-DPAT) obtained after systemic (IP) and intracerebral injection into the dorsal raphe nucleus (DRN) were selectively abolished by pretreatment with the 5-HT 1A receptor antagonist WAY-100635 ( N -(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)- N -(2-pyridinyl) cyclo-hexanecarboxamide trihydrochloride). This blockade was demonstrated both after systemic and DRN application of WAY-100635. Therefore, it is concluded that the anxiolytic effects of 8-OH-DPAT are mediated by activation of somatodendritic 5-HT 1A receptors.

Journal

Psychopharmacology – Springer Journals

Published: May 1, 1996

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