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Social withdrawal following amphetamine administration to marmosets

Social withdrawal following amphetamine administration to marmosets 213 99 99 2 2 L. E. Annett R. M. Ridley S. J. Gamble H. F. Baker Division of Psychiatry Clinical Research Centre Watford Road HA1 3UJ Harrow Middlesex UK Department of Experimental Psychology University of Cambridge Downing Street CB2 3EB Cambridge UK Abstract Approaches and leaves from social encounters by marmosets which had received amphetamine injected either intramuscularly or into the nucleus accumbens or caudate nucleus were recorded and used to determine whether social behaviour was disrupted as a result of behavioural competition or more active social withdrawal. The social isolation observed after the marmosets had received an IM injection of amphetamine (2 mg/kg) was not due to drug-induced increases in alternative behaviours. Drugged animals immediately withdrew from social encounters, interrupting their stereotypies in order to do so, whenever they were approached by an undrugged animal. In contrast, the reduced time spent in social encounters following amphetamine injections into the nucleus accumbens (10, 20 or 40 μg) appeared to be a direct consequence of the concurrent increase in locomotion. Animals continued to initiate social encounters despite being hyperactive. Amphetamine injections into the caudate nucleus were without effect on any of the social or individual behavioural measures. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Social withdrawal following amphetamine administration to marmosets

Annett, L.; Ridley, R.; Gamble, S.; Baker, H.
Psychopharmacology , Volume 99 (2) – Oct 1, 1989
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References (28)

Publisher
Springer Journals
Copyright
Copyright © 1989 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF00442812
Publisher site
See Article on Publisher Site

Abstract

213 99 99 2 2 L. E. Annett R. M. Ridley S. J. Gamble H. F. Baker Division of Psychiatry Clinical Research Centre Watford Road HA1 3UJ Harrow Middlesex UK Department of Experimental Psychology University of Cambridge Downing Street CB2 3EB Cambridge UK Abstract Approaches and leaves from social encounters by marmosets which had received amphetamine injected either intramuscularly or into the nucleus accumbens or caudate nucleus were recorded and used to determine whether social behaviour was disrupted as a result of behavioural competition or more active social withdrawal. The social isolation observed after the marmosets had received an IM injection of amphetamine (2 mg/kg) was not due to drug-induced increases in alternative behaviours. Drugged animals immediately withdrew from social encounters, interrupting their stereotypies in order to do so, whenever they were approached by an undrugged animal. In contrast, the reduced time spent in social encounters following amphetamine injections into the nucleus accumbens (10, 20 or 40 μg) appeared to be a direct consequence of the concurrent increase in locomotion. Animals continued to initiate social encounters despite being hyperactive. Amphetamine injections into the caudate nucleus were without effect on any of the social or individual behavioural measures.

Journal

Psychopharmacology – Springer Journals

Published: Oct 1, 1989

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