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outgrowth does the attraction begin to influence a fiber's direction of outgrowth? As long as a fiber grows out within the ln, it assumedly does not follow the attraction of a certain specific organ area (made free of organs by experimental denervation) or even of a single organ site (as developed in the normal maturation of the specimen). Outgrowing fibers may even enter the vr or a certain segmental dorsal or ventral segmental branch without being already attracted by one free receptor site in the special innervation area of this branch. They are, rather, directed to the one or other branch by stochastic events occurring within the In at the moment the outgrowing fiber tip passes the bifurcation site. Possibly, there is even no attraction at all. Up to now it cannot be excluded that the fibers at first spread out unspecifically in any direction and only the fibers arriving at an unoccupied site induce an organ and survive, the others becoming retracted, detoured, or degenerated. However, the ectopic In branches going on unusual paths straight ahead to distant receptor areas (Figs. 3, 5; see also Fig. 11 in [2], Figs. 2, 3 in [3]) suggest that some
Naturwissenschaften – Springer Journals
Published: Jun 1, 1994
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