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Simultaneous Determination of Benzodiazepines and Ketamine from Alcoholic and Nonalcoholic Beverages by GC-MS in Drug Facilitated Crimes

Simultaneous Determination of Benzodiazepines and Ketamine from Alcoholic and Nonalcoholic... A GC-MS method with HP-5MS capillary column was developed for the simultaneous determination of underivatized flunitrazepam, clonazepam, alprazolam, diazepam and ketamine from drinks by extraction with chloroform: isopropanol 1:1 (v/v). All linearity ranges were between 50 and 1,000 μg mL−1 for all compounds both in beer and in peach juice. Limit of detection was between 1.3 and 34.2 μg mL−1, limit of quantification was between 3.9 and 103.8 μg mL−1, the range of recoveries was 73.0 and 112.6% for all drugs in both beverages. The reported method was sensitive, rapid, and suitable for the analysis of the spiked drinks as evidence of sexual assault and robbery phenomena. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Chromatographia Springer Journals

Simultaneous Determination of Benzodiazepines and Ketamine from Alcoholic and Nonalcoholic Beverages by GC-MS in Drug Facilitated Crimes

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References (20)

Publisher
Springer Journals
Copyright
Copyright © 2009 by Vieweg+Teubner | GWV Fachverlage GmbH
Subject
Chemistry; Measurement Science and Instrumentation; Plant Sciences ; Biochemistry, general; Pharmacy; Organic Chemistry; Analytical Chemistry
ISSN
0009-5893
eISSN
1612-1112
DOI
10.1365/s10337-009-1278-6
Publisher site
See Article on Publisher Site

Abstract

A GC-MS method with HP-5MS capillary column was developed for the simultaneous determination of underivatized flunitrazepam, clonazepam, alprazolam, diazepam and ketamine from drinks by extraction with chloroform: isopropanol 1:1 (v/v). All linearity ranges were between 50 and 1,000 μg mL−1 for all compounds both in beer and in peach juice. Limit of detection was between 1.3 and 34.2 μg mL−1, limit of quantification was between 3.9 and 103.8 μg mL−1, the range of recoveries was 73.0 and 112.6% for all drugs in both beverages. The reported method was sensitive, rapid, and suitable for the analysis of the spiked drinks as evidence of sexual assault and robbery phenomena.

Journal

ChromatographiaSpringer Journals

Published: Aug 26, 2009

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