213 104 104 2 2 William A. Corrigall Kathleen M. Coen Addiction Research Foundation 33 Russell Street M5S 2S1 Toronto Ontario Canada Department of Physiology University of Toronto M5S 1A8 Toronto Ontario Canada Abstract The effects of selective D1 (SCH23390) and D2 (spiperone) dopamine antagonists, as well as of haloperidol, were examined on nicotine self-administration, food-maintained responding, and locomotor activity in rats. Antagonists reduced both operant responding and locomotor activity. Response patterns indicated that motor impairment was not the cause of the decreases, since responding was attenuated only in the latter half of operant sessions. Locomotor activity scores were significantly reduced by SCH23390, but not by spiperone. The effects of dopamine antagonists on nicotine self-administration are different from the effects of these antagonists on cocaine self-administration. Results are discussed in terms of the role of dopamine in drug reinforcement versus its role in sensorimotor integration.
Psychopharmacology – Springer Journals
Published: Jun 1, 1991
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