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Role of single-strand DNA 3′-5′ exonuclease ExoI and nuclease SbcCD in stationary-phase mutation in Escherichia coli K-12



In RecBCD + cells, a mutated single-strand DNA 3′-5′ exonuclease ExoI (SbcB15) induced an increase in stationary-phase mutation. In sbcB15 cells, as in wild-type cells, these mutations partially required RecA, RecB, RecF, and expression of the LexA regulon. The absence of nuclease SbcCD in sbcB15 cells decreased stationary-phase mutation and induced an increase in the number of cell filaments. The absence of ExoI (Δ xon ) in wild-type or sbcC cells did not change significantly the stationary-phase mutation. Differences between the sbcB15 and Δ xonA cells suggest a correlation between level of SOS induction and the generation of stationary-phase mutations.



Archives of MicrobiologySpringer Journals

Published: Feb 1, 2009

DOI: 10.1007/s00203-008-0441-z

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