Role of microglia in neuronal degeneration and regeneration

Role of microglia in neuronal degeneration and regeneration Microglial cells, the resident macrophage population of the central nervous system (CNS), actively scan tissue under both normal and pathologic contexts. Their resulting engagement can become either neuroprotective or neurotoxic, leading to amelioration or aggravation of disease progression. In this review, we focus on the molecular signaling molecules involved in microglial responses and discuss observations demonstrating the diverse effects of microglia in animal models of CNS diseases. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Seminars in Immunopathology Springer Journals

Role of microglia in neuronal degeneration and regeneration

Seminars in Immunopathology, Volume 31 (4) – Sep 9, 2009

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Publisher
Springer Journals
Copyright
Copyright © 2009 by Springer-Verlag
Subject
Biomedicine; Internal Medicine ; Immunology
ISSN
1863-2297
eISSN
1863-2300
DOI
10.1007/s00281-009-0180-5
pmid
19763574
Publisher site
See Article on Publisher Site

Abstract

Microglial cells, the resident macrophage population of the central nervous system (CNS), actively scan tissue under both normal and pathologic contexts. Their resulting engagement can become either neuroprotective or neurotoxic, leading to amelioration or aggravation of disease progression. In this review, we focus on the molecular signaling molecules involved in microglial responses and discuss observations demonstrating the diverse effects of microglia in animal models of CNS diseases.

Journal

Seminars in ImmunopathologySpringer Journals

Published: Sep 9, 2009

References

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