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Role of Adenosine Receptors in Neuroprotective Effect during Global Cerebral Ischemia

Role of Adenosine Receptors in Neuroprotective Effect during Global Cerebral Ischemia Selective A1 adenosine receptor agonists produced a considerable neuroprotective effect during global cerebral ischemia. The neuroprotective effect decreased in the order: A1 agonists-NECA-adenosine-A2A agonist CGS 21680, while selective A3 adenosine receptor agonist was ineffective. Inhibitory analysis showed that A1 adenosine receptors mediate the neuroprotective effect of CPA, are involved in the effects of NECA and adenosine (but not CGS 21680), and participate in natural resistance to cerebral ischemia. The role of A2B adenosine receptors in the realization of neuroprotective effects was also demonstrated. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Bulletin of Experimental Biology and Medicine Springer Journals

Role of Adenosine Receptors in Neuroprotective Effect during Global Cerebral Ischemia

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References (8)

Publisher
Springer Journals
Copyright
Copyright © 2001 by Plenum Publishing Corporation
Subject
Biomedicine; Biomedicine, general; Internal Medicine; Cell Biology; Pathology; Laboratory Medicine
ISSN
0007-4888
eISSN
1573-8221
DOI
10.1023/A:1017971831046
Publisher site
See Article on Publisher Site

Abstract

Selective A1 adenosine receptor agonists produced a considerable neuroprotective effect during global cerebral ischemia. The neuroprotective effect decreased in the order: A1 agonists-NECA-adenosine-A2A agonist CGS 21680, while selective A3 adenosine receptor agonist was ineffective. Inhibitory analysis showed that A1 adenosine receptors mediate the neuroprotective effect of CPA, are involved in the effects of NECA and adenosine (but not CGS 21680), and participate in natural resistance to cerebral ischemia. The role of A2B adenosine receptors in the realization of neuroprotective effects was also demonstrated.

Journal

Bulletin of Experimental Biology and MedicineSpringer Journals

Published: Oct 19, 2004

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