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L. Rusche, J. Cruz-Reyes, K. Piller, B. Sollner‐Webb (1997)
Purification of a functional enzymatic editing complex from Trypanosoma brucei mitochondriaThe EMBO Journal, 16
G. Martin, W. Keller (1998)
Tailing and 3'-end labeling of RNA with yeast poly(A) polymerase and various nucleotides.RNA, 4 2
M. Peris, G. Frech, A. Simpson, F. Bringaud, E. Byrne, A. Bakker, L. Simpson (1994)
Characterization of two classes of ribonucleoprotein complexes possibly involved in RNA editing from Leishmania tarentolae mitochondria.The EMBO Journal, 13
L. Aravind, E. Koonin (1999)
DNA polymerase beta-like nucleotidyltransferase superfamily: identification of three new families, classification and evolutionary history.Nucleic acids research, 27 7
G. Gao, L. Simpson (2003)
Is the Trypanosoma brucei REL1 RNA Ligase Specific for U-deletion RNA Editing, and Is the REL2 RNA Ligase Specific for U-insertion Editing?*Journal of Biological Chemistry, 278
R. Igo, S. Palazzo, M. Burgess, A. Panigrahi, K. Stuart (2000)
Uridylate Addition and RNA Ligation Contribute to the Specificity of Kinetoplastid Insertion RNA EditingMolecular and Cellular Biology, 20
S. Kapushoc, L. Simpson (1999)
In vitro uridine insertion RNA editing mediated by cis-acting guide RNAs.RNA, 5 5
David Fortner, Raymond Troy, D. Brow (1994)
A stem/loop in U6 RNA defines a conformational switch required for pre-mRNA splicing.Genes & development, 8 2
L. Simpson, O. Thiemann, N. Savill, J. Alfonzo, D. Maslov (2000)
Evolution of RNA editing in trypanosome mitochondria.Proceedings of the National Academy of Sciences of the United States of America, 97 13
Barbara Pannone, Sang Kim, Dennis Noe, S. Wolin (2001)
Multiple functional interactions between components of the Lsm2-Lsm8 complex, U6 snRNA, and the yeast La protein.Genetics, 158 1
K. Stuart, A. Schnaufer, N. Ernst, A. Panigrahi (2005)
Complex management: RNA editing in trypanosomes.Trends in biochemical sciences, 30 2
Jae Kwak, Liaoteng Wang, S. Ballantyne, J. Kimble, M. Wickens (2004)
Mammalian GLD-2 homologs are poly(A) polymerases.Proceedings of the National Academy of Sciences of the United States of America, 101 13
T. White, P. Borst (1987)
RNA end-labeling and RNA ligase activities can produce a circular rRNA in whole cell extracts from trypanosomes.Nucleic acids research, 15 8
J. Cruz-Reyes, Alevtina Zhelonkina, Catherine Huang, B. Sollner‐Webb (2002)
Distinct Functions of Two RNA Ligases in Active Trypanosoma brucei RNA Editing ComplexesMolecular and Cellular Biology, 22
N. Bakalara, A. Simpson, L. Simpson (1989)
The Leishmania kinetoplast-mitochondrion contains terminal uridylyltransferase and RNA ligase activities.The Journal of biological chemistry, 264 31
Edinburgh Research Explorer Identification of novel components of Trypanosoma brucei editosomes
R. Aphasizhev, L. Simpson (2001)
Isolation and Characterization of a U-specific 3′-5′-Exonuclease from Mitochondria of Leishmania tarentolae *The Journal of Biological Chemistry, 276
(2003)
Biochemical characterization of a U 6 small nuclear RNAspecific terminal uridylyltransferase
B. Blum, L. Simpson (1990)
Guide RNAs in kinetoplastid mitochondria have a nonencoded 3′ oligo(U) tail involved in recognition of the preedited regionCell, 62
Joel Bard, A. Zhelkovsky, S. Helmling, Thomas Earnest, Claire Moore, Andrew Bohm (2000)
Structure of yeast poly(A) polymerase alone and in complex with 3'-dATP.Science, 289 5483
B. Booth, Frank Pugh (1997)
Identification and Characterization of a Nuclease Specific for the 3′ End of the U6 Small Nuclear RNA*The Journal of Biological Chemistry, 272
R. Igo, S. Lawson, K. Stuart (2002)
RNA Sequence and Base Pairing Effects on Insertion Editing in Trypanosoma bruceiMolecular and Cellular Biology, 22
C. Decker, B. Sollner‐Webb (1990)
RNA editing involves indiscriminate U changes throughout precisely defined editing domainsCell, 61
W. Keller, G. Martin (2002)
Gene regulation: Reviving the messageNature, 419
Laurie Read, Peter Myler, Kenneth Stuart (1992)
Extensive editing of both processed and preprocessed maxicircle CR6 transcripts in Trypanosoma brucei.The Journal of biological chemistry, 267 2
P. Gershon, B. Ahn, M. Garfield, B. Moss (1991)
Poly(A) polymerase and a dissociable polyadenylation stimulatory factor encoded by vaccinia virusCell, 66
Daron Barnard, K. Ryan, J. Manley, J. Richter (2004)
Symplekin and xGLD-2 Are Required for CPEB-Mediated Cytoplasmic PolyadenylationCell, 119
E. Byrne, G. Connell, L. Simpson (1996)
Guide RNA‐directed uridine insertion RNA editing in vitro.The EMBO Journal, 15
E. Lund, J. Dahlberg (1992)
Cyclic 2',3'-phosphates and nontemplated nucleotides at the 3' end of spliceosomal U6 small nuclear RNA's.Science, 255 5042
M. Burgess, S. Heidmann, K. Stuart (1999)
Kinetoplastid RNA editing does not require the terminal 3' hydroxyl of guide RNA, but modifications to the guide RNA terminus can inhibit in vitro U insertion.RNA, 5 7
J. Cruz-Reyes, Alevtina Zhelonkina, L. Rusche, B. Sollner‐Webb (2001)
Trypanosome RNA Editing: Simple Guide RNA Features Enhance U Deletion 100-FoldMolecular and Cellular Biology, 21
G. Martin, Walter Keller (1996)
Mutational analysis of mammalian poly(A) polymerase identifies a region for primer binding and catalytic domain, homologous to the family X polymerases, and to other nucleotidyltransferases.The EMBO Journal, 15
S. Seiwert, S. Heidmann, K. Stuart (1996)
Direct Visualization of Uridylate Deletion In Vitro Suggests a Mechanism for Kinetoplastid RNA EditingCell, 84
R. Benne, J. Burg, J. Brakenhoff, P. Sloof, J. Boom, M. Tromp (1986)
Major transcript of the frameshifted coxll gene from trypanosome mitochondria contains four nucleotides that are not encoded in the DNACell, 46
R. Aphasizhev, I. Aphasizheva, R. Nelson, L. Simpson (2003)
A 100-kD complex of two RNA-binding proteins from mitochondria of Leishmania tarentolae catalyzes RNA annealing and interacts with several RNA editing components.RNA, 9 1
R. Aphasizhev, S. Sbicego, M. Peris, S. Jang, I. Aphasizheva, A. Simpson, A. Rivlin, L. Simpson (2002)
Trypanosome Mitochondrial 3′ Terminal Uridylyl Transferase (TUTase) The Key Enzyme in U-Insertion/Deletion RNA EditingCell, 108
K. Perumal, R. Reddy (2002)
The 3' end formation in small RNAs.Gene expression, 10 1-2
L. Holm, C. Sander (1995)
DNA polymerase beta belongs to an ancient nucleotidyltransferase superfamily.Trends in biochemical sciences, 20 9
C. Will, R. Lührmann (2001)
Spliceosomal UsnRNP biogenesis, structure and function.Current opinion in cell biology, 13 3
L. Simpson, R. Aphasizhev, G. Gao, X. Kang (2004)
Mitochondrial proteins and complexes in Leishmania and Trypanosoma involved in U-insertion/deletion RNA editing.RNA, 10 2
T. Achsel, H. Brahms, B. Kastner, A. Bachi, M. Wilm, R. Lührmann (1999)
A doughnut‐shaped heteromer of human Sm‐like proteins binds to the 3′‐end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitroThe EMBO Journal, 18
A. Schnaufer, N. Ernst, S. Palazzo, J. O'Rear, R. Salavati, K. Stuart (2003)
Separate insertion and deletion subcomplexes of the Trypanosoma brucei RNA editing complex.Molecular cell, 12 2
I. Rogozin, L. Aravind, E. Koonin (2003)
Differential action of natural selection on the N and C-terminal domains of 2'-5' oligoadenylate synthetases and the potential nuclease function of the C-terminal domain.Journal of molecular biology, 326 5
Michael McManus, B. Adler, V. Pollard, S. Hajduk (2000)
Trypanosoma brucei Guide RNA Poly(U) Tail Formation Is Stabilized by Cognate mRNAMolecular and Cellular Biology, 20
G. Frech, N. Bakalara, L. Simpson, A. Simpson (1995)
In vitro RNA editing‐like activity in a mitochondrial extract from Leishmania tarentolae.The EMBO Journal, 14
Steitz Ta (1997)
DNA and RNA polymerases: structural diversity and common mechanisms.Harvey Lectures, 93
G. Martin, Andreas Möglich, W. Keller, S. Doublié (2004)
Biochemical and structural insights into substrate binding and catalytic mechanism of mammalian poly(A) polymerase.Journal of molecular biology, 341 4
V. Pollard, Michael Harris, S. Hajduk (1992)
Native mRNA editing complexes from Trypanosoma brucei mitochondria.The EMBO Journal, 11
L. Vanhamme, D. Perez-Morga, C. Marchal, D. Speijer, L. Lambert, M. Geuskens, S. Alexandre, N. Ismaı̈li, U. Göringer, R. Benne, E. Pays (1998)
Trypanosoma brucei TBRGG1, a Mitochondrial Oligo(U)-binding Protein That Co-localizes with an in VitroRNA Editing Activity*The Journal of Biological Chemistry, 273
E. Byrne, F. Bringaud, L. Simpson (1995)
RNA-protein interactions in the ribonucleoprotein T-complexes in a mitochondrial extract from Leishmania tarentolae.Molecular and biochemical parasitology, 72 1-2
G. Martin, W. Keller, S. Doublié (2000)
Crystal structure of mammalian poly(A) polymerase in complex with an analog of ATPThe EMBO Journal, 19
B. Blum, N. Bakalara, L. Simpson (1990)
A model for RNA editing in kinetoplastid mitochondria: RNA molecules transcribed from maxicircle DNA provide the edited informationCell, 60
S. Leung, D. Koslowsky (2001)
Interactions of mRNAs and gRNAs involved in trypanosome mitochondrial RNA editing: structure probing of an mRNA bound to its cognate gRNA.RNA, 7 12
B. Adler, Michael Harris, Karen Bertrand, S. Hajduk (1991)
Modification of Trypanosoma brucei mitochondrial rRNA by posttranscriptional 3' polyuridine tail formationMolecular and Cellular Biology, 11
T. Traut (1994)
Physiological concentrations of purines and pyrimidinesMolecular and Cellular Biochemistry, 140
L. Raynal, A. Carpousis (1999)
Poly(A) polymerase I of Escherichia coli: characterization of the catalytic domain, an RNA binding site and regions for the interaction with proteins involved in mRNA degradationMolecular Microbiology, 32
N. Sturm, L. Simpson (1991)
Leishmania tarentolae minicircles of different sequence classes encode single guide RNAs located in the variable region approximately 150 bp from the conserved region.Nucleic acids research, 19 22
C. Ryan, L. Read (2005)
UTP-dependent turnover of Trypanosoma brucei mitochondrial mRNA requires UTP polymerization and involves the RET1 TUTase.RNA, 11 5
J. Rinke, J. Steitz (1985)
Association of the lupus antigen La with a subset of U6 snRNA molecules.Nucleic acids research, 13 7
J. Lukeš, D. Guilbride, J. Votýpka, A. Zíková, R. Benne, P. Englund (2002)
Kinetoplast DNA Network: Evolution of an Improbable StructureEukaryotic Cell, 1
R. Reddy, D. Henning, G. Das, M. Harless, D. Wright (1987)
The capped U6 small nuclear RNA is transcribed by RNA polymerase III.The Journal of biological chemistry, 262 1
R. Read, R. Martinho, Shao-Win Wang, A. Carr, C. Norbury (2002)
Cytoplasmic poly(A) polymerases mediate cellular responses to S phase arrestProceedings of the National Academy of Sciences of the United States of America, 99
J. Cruz-Reyes, L. Rusche, K. Piller, B. Sollner‐Webb (1998)
T. brucei RNA editing: adenosine nucleotides inversely affect U-deletion and U-insertion reactions at mRNA cleavage.Molecular cell, 1 3
Julie Law, Catherine Huang, Sean O’Hearn, B. Sollner‐Webb (2005)
In Trypanosoma brucei RNA Editing, Band II Enables Recognition Specifically at Each Step of the U Insertion CycleMolecular and Cellular Biology, 25
R. Aphasizhev, I. Aphasizheva, R. Nelson, G. Gao, A. Simpson, X. Kang, A. Falick, S. Sbicego, L. Simpson (2003)
Isolation of a U‐insertion/deletion editing complex from Leishmania tarentolae mitochondriaThe EMBO Journal, 22
M. Kable, S. Seiwert, S. Heidmann, K. Stuart (1996)
RNA Editing: A Mechanism for gRNA-Specified Uridylate Insertion into Precursor mRNAScience, 273
R. Aphasizhev, I. Aphasizheva, L. Simpson (2004)
Multiple terminal uridylyltransferases of trypanosomesFEBS Letters, 572
M. Neboháčová, D. Maslov, A. Falick, L. Simpson (2004)
The Effect of RNA Interference Down-regulation of RNA Editing 3′-Terminal Uridylyl Transferase (TUTase) 1 on Mitochondrial de Novo Protein Synthesis and Stability of Respiratory Complexes in Trypanosoma brucei*Journal of Biological Chemistry, 279
C. Clayton (2002)
Life without transcriptional control? From fly to man and back againThe EMBO Journal, 21
O. Thiemann, L. Simpson (1996)
Analysis of the 3' uridylylation sites of guide RNAs from Leishmania tarentolae.Molecular and biochemical parasitology, 79 2
D. Blom, J. Burg, C. Breek, D. Speijer, A. Muijsers, R. Benne (2001)
Cloning aid characterization of two guide RNA-binding proteins from mitochondria of Crithidia fasciculata : gBP 27 , a novel protein , and gBP 29 , the orthologue of Trypanosoma brucei gBP 21
P. Macdonald (2001)
Diversity in translational regulation.Current opinion in cell biology, 13 3
R. Aphasizhev, I. Aphasizheva, L. Simpson (2003)
A tale of two TUTasesProceedings of the National Academy of Sciences of the United States of America, 100
I. Aphasizheva, R. Aphasizhev, L. Simpson (2004)
RNA-editing Terminal Uridylyl Transferase 1Journal of Biological Chemistry, 279
D. Golden, S. Hajduk (2005)
The 3'-untranslated region of cytochrome oxidase II mRNA functions in RNA editing of African trypanosomes exclusively as a cis guide RNA.RNA, 11 1
D. Xue, D. Rubinson, Barbara Pannone, C. Yoo, S. Wolin (2000)
U snRNP assembly in yeast involves the La proteinThe EMBO Journal, 19
Vadim Agol, A. Paul, Eckard Wimmer (1999)
Paradoxes of the replication of picornaviral genomes.Virus research, 62 2
D. Maslov, L. Simpson (1992)
The polarity of editing within a multiple gRNA-mediated domain is due to formation of anchors for upstream gRNAs by downstream editingCell, 70
V. Blanc, J. Alfonzo, R. Aphasizhev, L. Simpson (1999)
The Mitochondrial RNA Ligase from Leishmania tarentolae Can Join RNA Molecules Bridged by a Complementary RNA*The Journal of Biological Chemistry, 274
X. Kang, K. Rogers, G. Gao, A. Falick, Sharleen Zhou, L. Simpson (2005)
Reconstitution of uridine-deletion precleaved RNA editing with two recombinant enzymes.Proceedings of the National Academy of Sciences of the United States of America, 102 4
S. Saitoh, A. Chabes, W. McDonald, L. Thelander, J. Yates, P. Russell (2002)
Cid13 Is a Cytoplasmic Poly(A) Polymerase that Regulates Ribonucleotide Reductase mRNACell, 109
Liaoteng Wang, C. Eckmann, L. Kadyk, M. Wickens, J. Kimble (2002)
A regulatory cytoplasmic poly(A) polymerase in Caenorhabditis elegansNature, 419
Ralf Trippe, B. Sandrock, B. Benecke (1998)
A highly specific terminal uridylyl transferase modifies the 3'-end of U6 small nuclear RNANucleic acids research, 26 13
L. Iyer, E. Koonin, L. Aravind (2003)
Evolutionary connection between the catalytic subunits of DNA-dependent RNA polymerases and eukaryotic RNA-dependent RNA polymerases and the origin of RNA polymerasesBMC Structural Biology, 3
N. Ernst, B. Panicucci, R. Igo, A. Panigrahi, R. Salavati, K. Stuart (2003)
TbMP57 is a 3' terminal uridylyl transferase (TUTase) of the Trypanosoma brucei editosome.Molecular cell, 11 6
.The terminal RNA uridylyltransferases (TUTases) catalyze transfer of UMP residues to the 3′ hydroxyl group of RNA. These activities are widespread among eukaryotes and appear to be involved in a variety of RNA-processing pathways. Recent studies of RNA editing in trypanosomatids have provided the first insights into the biological functions of RNA uridylyltransferases, which had eluded biochemical identification despite 30-year-old evidence of such activities in mammals and plants. Comparative sequence analysis of trypanosomal TUTases and their homologs revealed by large-scale genomic projects demonstrates a significant level of biochemical and structural diversity between putative uridylyltransferases. The conserved catalytic domain has acquired additional protein modules and appears to have adapted to perform functionally distinct tasks of guided U-insertion into mRNA and constrained addition of an oligo[U] tail to guide RNAs. Here I discuss the current knowledge of this novel enzyme family and possible roles of RNA uridylylation in the regulation of gene expression.
Cellular and Molecular Life Sciences – Springer Journals
Published: Oct 1, 2005
Keywords: Uridylyltransferase; TUTase; RNA editing; editosome; Trypanosoma; Leishmania; gRNA; U6 snRNP; cytoplasmic poly(A) polymerase
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